FAD104, a regulator of adipogenesis, is a novel suppressor of TGF-β–mediated EMT in cervical cancer cells
Sign Up to like & getrecommendations! Published in 2017 at "Scientific Reports"
DOI: 10.1038/s41598-017-16555-3
Abstract: Epithelial-to-mesenchymal transition (EMT) is a biological process in which epithelial cells translate into a mesenchymal phenotype with invasive capacities, contributing to tumour progression, metastasis, and the acquisition of chemotherapy resistance. To identify new therapeutic targets… read more here.
Keywords: tgf mediated; cervical cancer; mediated emt; cancer cells ... See more keywords
KLF2 inhibits TGF-β-mediated cancer cell motility in hepatocellular carcinoma.
Sign Up to like & getrecommendations! Published in 2020 at "Acta biochimica et biophysica Sinica"
DOI: 10.1093/abbs/gmaa024
Abstract: Feedback regulation plays a pivotal role in determining the intensity and duration of TGF-β signaling and subsequently affecting the pathophysiological roles of TGF-β, including those in liver malignancy. KLF2, a member of the Krüppel-like factor… read more here.
Keywords: hepatocellular carcinoma; cell motility; cancer cell; klf2 inhibits ... See more keywords
Artesunate inhibits proliferation and migration of RPE cells and TGF-β2 mediated epithelial mesenchymal transition by suppressing PI3K/AKT pathway.
Sign Up to like & getrecommendations! Published in 2022 at "International journal of ophthalmology"
DOI: 10.18240/ijo.2022.02.02
Abstract: AIM To study the braking effectiveness of artesunate on transforming growth factor (TGF)-β2 mediated epithelial-mesenchymal transition (EMT) in retinal pigment epithelium (RPE) in vitro. METHODS The fostered ARPE-19 cells were processed with artesunate alone or… read more here.
Keywords: pi3k akt; tgf mediated; mediated epithelial; phospho ... See more keywords
Schisandrol B and schisandrin B inhibit TGFβ1-mediated NF-κB activation via a Smad-independent mechanism
Sign Up to like & getrecommendations! Published in 2018 at "Oncotarget"
DOI: 10.18632/oncotarget.23213
Abstract: Aberrant transforming growth factor β1 (TGFβ1) signaling plays a pathogenic role in the development of vascular fibrosis. We have reported that Schisandra chinensis fruit extract (SCE), which has been used as a traditional oriental medicine,… read more here.
Keywords: smad independent; tgf; independent mechanism; mediated activation ... See more keywords