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   Articles with "tgf pdgf" as a keyword



Enhancer of Zeste Homologue 2 Inhibition Attenuates TGF-β Dependent Hepatic Stellate Cell Activation and Liver Fibrosis

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recommendations! Published in 2019 at "Cellular and Molecular Gastroenterology and Hepatology"

DOI: 10.1016/j.jcmgh.2018.09.005

Abstract: Background & Aims Transdifferentiation of hepatic stellate cells (HSCs) into myofibroblasts is a key event in the pathogenesis of liver fibrosis. Transforming growth factor β (TGF-β) and platelet-derived growth factor (PDGF) are canonical HSC activators… read more here.

Keywords: fibrosis; liver fibrosis; inhibition; tgf pdgf ... See more keywords

Cytokine Profiling and Clinical Correlates of Conjunctival Wound Healing After Trabeculectomy: Implications for Scar Formation in Glaucoma Patients

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recommendations! Published in 2025 at "Ocular Immunology and Inflammation"

DOI: 10.1080/09273948.2025.2516081

Abstract: ABSTRACT Purpose Understanding the role of scar markers and inflammatory factors in filtering bleb scarring after glaucoma surgery is essential for improving conjunctival wound healing and surgical outcomes. This study aimed to investigate conjunctival wound… read more here.

Keywords: glaucoma patients; glaucoma; conjunctival wound; wound healing ... See more keywords

Regulatory cytokines prescribe the outcome of the inflammation in the process of PEX production.

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recommendations! Published in 2019 at "Journal of the Chinese Medical Association"

DOI: 10.1097/jcma.0000000000000214

Abstract: BACKGROUND The purpose of this study is to reveal the participation of different regulatory cytokines within the process of pseudoexfoliation (PEX). METHODS Our study included 140 patients referred to cataract surgery with early and late… read more here.

Keywords: regulatory cytokines; process; production; pex ... See more keywords

Dual inhibition of TGFβ and PDGF improves RV remodeling and function in response to RV pressure or volume‐loading

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recommendations! Published in 2025 at "Physiological Reports"

DOI: 10.14814/phy2.70339

Abstract: Right ventricular (RV) pressure and volume loading induce RV fibrosis in association with RV dysfunction, morbidity, and mortality in repaired tetralogy of Fallot. Transforming‐growth factor‐β1 (TGFβ1) and platelet‐derived growth factor (PDGF) activate common downstream signaling… read more here.

Keywords: tgf pdgf; pressure volume; pdgf; volume loading ... See more keywords

Endostatin attenuates PDGF-BB- or TGF-β1-induced HSCs activation via suppressing RhoA/ROCK1 signal pathways

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recommendations! Published in 2019 at "Drug Design, Development and Therapy"

DOI: 10.2147/dddt.s191617

Abstract: Aim To testify the hypothesis that endostatin exerts antifibrotic effects in hepatic stellate cells (HSCs) by modulating RhoA (ras homolog gene family, member A)/ROCK 1 (Rho-associated protein kinase 1) signal pathways. Materials and methods HSCs-T6… read more here.

Keywords: hscs; signal pathways; group; rhoa rock1 ... See more keywords