Enhancer of Zeste Homologue 2 Inhibition Attenuates TGF-β Dependent Hepatic Stellate Cell Activation and Liver Fibrosis
Sign Up to like & getrecommendations! Published in 2019 at "Cellular and Molecular Gastroenterology and Hepatology"
DOI: 10.1016/j.jcmgh.2018.09.005
Abstract: Background & Aims Transdifferentiation of hepatic stellate cells (HSCs) into myofibroblasts is a key event in the pathogenesis of liver fibrosis. Transforming growth factor β (TGF-β) and platelet-derived growth factor (PDGF) are canonical HSC activators… read more here.
Keywords: fibrosis; liver fibrosis; inhibition; tgf pdgf ... See more keywords
Regulatory cytokines prescribe the outcome of the inflammation in the process of PEX production.
Sign Up to like & getrecommendations! Published in 2019 at "Journal of the Chinese Medical Association"
DOI: 10.1097/jcma.0000000000000214
Abstract: BACKGROUND The purpose of this study is to reveal the participation of different regulatory cytokines within the process of pseudoexfoliation (PEX). METHODS Our study included 140 patients referred to cataract surgery with early and late… read more here.
Keywords: regulatory cytokines; process; production; pex ... See more keywords
Endostatin attenuates PDGF-BB- or TGF-β1-induced HSCs activation via suppressing RhoA/ROCK1 signal pathways
Sign Up to like & getrecommendations! Published in 2019 at "Drug Design, Development and Therapy"
DOI: 10.2147/dddt.s191617
Abstract: Aim To testify the hypothesis that endostatin exerts antifibrotic effects in hepatic stellate cells (HSCs) by modulating RhoA (ras homolog gene family, member A)/ROCK 1 (Rho-associated protein kinase 1) signal pathways. Materials and methods HSCs-T6… read more here.
Keywords: hscs; signal pathways; group; rhoa rock1 ... See more keywords