The pancreatic cancer immune tumor microenvironment is negatively remodeled by gemcitabine while TGF‐β receptor plus dual checkpoint inhibition maintains antitumor immune cells
Sign Up to like & getrecommendations! Published in 2022 at "Molecular Carcinogenesis"
DOI: 10.1002/mc.23401
Abstract: Pancreatic ductal adenocarcinoma (PDA) tumors have a highly immunosuppressive desmoplastic tumor microenvironment (TME) where immune checkpoint inhibition (ICI) therapy has been exceptionally ineffective. Transforming growth factor‐β (TGF‐β) receptor activation leads to cancer and immune cell… read more here.
Keywords: inhibition; tgf receptor; checkpoint; tumor ... See more keywords
TGF‐β receptor mutations and clinical prognosis in Chinese pediatric patients with idiopathic/hereditary pulmonary arterial hypertension
Sign Up to like & getrecommendations! Published in 2022 at "Pulmonary Circulation"
DOI: 10.1002/pul2.12076
Abstract: Abstract The relationship between clinical prognosis and transforming growth factor‐β (TGF‐β) receptor mutations in Chinese pediatric patients with idiopathic/hereditary pulmonary arterial hypertension (IPAH/HPAH) remains unclear. We retrospectively studied the clinical characteristics and outcomes of pediatric… read more here.
Keywords: prognosis; tgf receptor; receptor mutations; pediatric patients ... See more keywords
Ochratoxin a induces hepatic fibrosis through TGF‐β receptor I/Smad2/3 signaling pathway
Sign Up to like & getrecommendations! Published in 2022 at "Environmental Toxicology"
DOI: 10.1002/tox.23552
Abstract: Ochratoxin A (OTA) is a mycotoxin generated by Penicillium and Aspergillus species. It is often found in cereals. We hypothesized that OTA exposure induces epithelial–mesenchymal transition (EMT), leading to liver fibrosis. In this research, we… read more here.
Keywords: tgf receptor; hepatic fibrosis; smad2 signaling; tgf ... See more keywords
Visualization of Endogenous Type I TGF-β Receptor Baboon in the Drosophila Brain
Sign Up to like & getrecommendations! Published in 2020 at "Scientific Reports"
DOI: 10.1038/s41598-020-61950-y
Abstract: The transforming growth factor β (TGF-β) signaling pathway is evolutionarily conserved and widely used in the animal kingdom to regulate diverse developmental processes. Prior studies have shown that Baboon (Babo), a Drosophila type I TGF-β… read more here.
Keywords: drosophila; visualization endogenous; tgf receptor; type tgf ... See more keywords
Loss of TGF-β signaling drives cSCC from skin stem cells – More evidence
Sign Up to like & getrecommendations! Published in 2017 at "Cell Cycle"
DOI: 10.1080/15384101.2016.1259892
Abstract: Tangible therapeutic advances for aggressive and potentially lethal forms of cutaneous squamous cell carcinoma (cSCC), one of the most common forms of cancer, are currently lacking. As our aging population continues to suffer from its… read more here.
Keywords: evidence; tgf; tgf receptor; tgf signaling ... See more keywords
MicroRNA-130a attenuates cardiac fibrosis after myocardial infarction through TGF-β/Smad signaling by directly targeting TGF-β receptor 1
Sign Up to like & getrecommendations! Published in 2022 at "Bioengineered"
DOI: 10.1080/21655979.2022.2033380
Abstract: ABSTRACT Cardiac fibrosis is a common pathophysiological change associated with myocardial infarction (MI), and while there is evidence that miR-130a plays an important role in a variety of fibrotic diseases, its role in the cardiac… read more here.
Keywords: cardiac fibrosis; mir 130a; tgf receptor; myocardial infarction ... See more keywords
ALK1 regulates the internalization of endoglin and the type III TGF-β receptor
Sign Up to like & getrecommendations! Published in 2021 at "Molecular Biology of the Cell"
DOI: 10.1091/mbc.e20-03-0199
Abstract: Complex formation and endocytosis of transforming growth factor-β (TGF-β) receptors play important roles in signaling. However, their interdependence remained unexplored. Here, we demonstrate that ALK1, a TGF-β type I receptor prevalent in endothelial cells, forms… read more here.
Keywords: tgf; endocytosis; alk1; tgf receptor ... See more keywords
TGFβ receptor inhibition unleashes interferon-β production by tumor-associated macrophages and enhances radiotherapy efficacy
Sign Up to like & getrecommendations! Published in 2022 at "Journal for Immunotherapy of Cancer"
DOI: 10.1136/jitc-2021-003519
Abstract: Background Transforming growth factor-beta (TGFβ) can limit the efficacy of cancer treatments, including radiotherapy (RT), by inducing an immunosuppressive tumor environment. The association of TGFβ with impaired T cell infiltration and antitumor immunity is known,… read more here.
Keywords: inhibition; tgf receptor; efficacy; tgf ... See more keywords
TGF-β receptor I inhibitor may restrict the induction of EMT in inflamed intestinal epithelial cells.
Sign Up to like & getrecommendations! Published in 2023 at "Experimental biology and medicine"
DOI: 10.1177/15353702231151959
Abstract: Despite the extensive body of research, understanding the exact molecular mechanisms governing inflammatory bowel diseases (IBDs) still demands further investigation. Transforming growth factor-β1 (TGF-β1) signaling possesses a multifacial effect on a broad range of context-dependent… read more here.
Keywords: emt; tgf receptor; receptor inhibitor; epithelial cells ... See more keywords
TGF-β Signalling is Suppressed under Pro-Hypertrophic Conditions in MSC Chondrogenesis Due to TGF-β Receptor Downregulation
Sign Up to like & getrecommendations! Published in 2019 at "International Journal of Stem Cells"
DOI: 10.15283/ijsc18088
Abstract: Background and Objectives Mesenchymal stem cells (MSCs) become hypertrophic in long term despite chondrogenic differentiation following the pathway of growth plate chondrocytes. This terminal differentiation leads to phenotypically unstable cartilage and was mirrored in vitro… read more here.
Keywords: pro hypertrophic; hypertrophic conditions; tgf; hypertrophy ... See more keywords
Mechanism of action and efficacy of LY2109761, a TGF-β receptor inhibitor, targeting tumor microenvironment in liver cancer after TACE
Sign Up to like & getrecommendations! Published in 2018 at "Oncotarget"
DOI: 10.18632/oncotarget.23193
Abstract: TACE (transcatheter arterial chemoembolization) has been recognized as an effective palliative treatment option for patients with HCC, however, the medium-long term efficacy of it remains modest. LY2109761, a TGF-β receptor inhibitor, was confirmed to reduce… read more here.
Keywords: ly2109761 tgf; tace; tgf receptor; tumor ... See more keywords