Nanoparticle-Based MRI-Guided Tumor Microenvironment Heating via the Synergistic Effect of Ferroptosis and Inhibition of TGF-β Signaling.
Sign Up to like & getrecommendations! Published in 2023 at "Advanced healthcare materials"
DOI: 10.1002/adhm.202300176
Abstract: Although induction of ferroptosis and inhibition of transforming growth factor-β (TGF-β) signaling are both effective ways to reform the tumor microenvironment (TME) and render low-immunogenic tumors responsive to immune checkpoint inhibitor (ICI) therapy, dose-limiting side… read more here.
Keywords: tumor microenvironment; ferroptosis inhibition; tumor; tgf signaling ... See more keywords
Transforming growth factor‐β family biology: From basic mechanisms to roles in development and disease
Sign Up to like & getrecommendations! Published in 2022 at "Developmental Dynamics"
DOI: 10.1002/dvdy.445
Abstract: The transforming growth factor-β (TGF-β) family of ligands comprises 33 members in humans, of which 30 are positively acting ligands including the TGF-βs, the Activins, the bone morphogenetic proteins (BMPs), the growth and differentiation factors… read more here.
Keywords: growth; biology; family; tgf family ... See more keywords
Postnatal maturation of microglia is associated with alternative activation and activated TGFβ signaling
Sign Up to like & getrecommendations! Published in 2018 at "Glia"
DOI: 10.1002/glia.23332
Abstract: Microglia are involved in a widespread set of physiological and pathological processes and further play important roles during neurodevelopmental events. Postnatal maturation of microglia has been associated with the establishment of microglia‐specific gene expression patterns.… read more here.
Keywords: tgf; maturation; tgf signaling; postnatal maturation ... See more keywords
Deletion of Tgfβ signal in activated microglia prolongs hypoxia‐induced retinal neovascularization enhancing Igf1 expression and retinal leukostasis
Sign Up to like & getrecommendations! Published in 2022 at "Glia"
DOI: 10.1002/glia.24218
Abstract: Retinal neovascularization (NV) is the major cause of severe visual impairment in patients with ischemic eye diseases. While it is known that retinal microglia contribute to both physiological and pathological angiogenesis, the molecular mechanisms by… read more here.
Keywords: activated microglia; igf1 expression; retinal neovascularization; tgf ... See more keywords
Polycomb complex mediated epigenetic reprogramming alters TGF‐β signaling via a novel EZH2/miR‐490/TGIF2 axis thereby inducing migration and EMT potential in glioblastomas
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DOI: 10.1002/ijc.32360
Abstract: Recent advancement in understanding cancer etiology has highlighted epigenetic deregulation as an important phenomenon leading to poor prognosis in glioblastoma (GBM). Polycomb repressive complex 2 (PRC2) is one such important epigenetic modifier reportedly altered in… read more here.
Keywords: mir 490; migration emt; gbm; polycomb ... See more keywords
TrkC‐miR2 regulates TGFβ signaling pathway through targeting of SMAD3 transcript
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Cellular Biochemistry"
DOI: 10.1002/jcb.27572
Abstract: TrkC, neurotrophin receptor, functions inside and outside of the nervous system and has a crucial effect on the regulation of cardiovascular formation. Recently, we introduced TrkC‐miR2 as a novel microRNA located in TrkC gene, which… read more here.
Keywords: signaling pathway; mir2; trkc mir2; regulates tgf ... See more keywords
TGFβ signaling controls intrahepatic bile duct development may through regulating the Jagged1‐Notch‐Sox9 signaling axis
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Cellular Physiology"
DOI: 10.1002/jcp.26304
Abstract: Due to the inherent limitations of the mouse models, the molecular mechanism of TGFβ signaling involved in the development of intrahepatic bile ducts (IHBDs) has been investigated little. Here, we investigated the role of TGFβ… read more here.
Keywords: tgf signaling; notch; tgf; sox9 ... See more keywords
Role of TGF‐β signaling regulatory microRNAs in the pathogenesis of colorectal cancer
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Cellular Physiology"
DOI: 10.1002/jcp.28169
Abstract: Transforming growth factor β (TGF‐β) modulates tumor progression by regulating cell proliferation, apoptosis, metastasis, angiogenesis, and drug resistance. Biological and pharmacological agonists/antagonists, the interplay between intracellular signaling pathways, and microRNAs (miRNAs) control the initiation and… read more here.
Keywords: role tgf; pathogenesis; tgf; signaling regulatory ... See more keywords
Folic acid rescues corticosteroid‐induced vertebral malformations in chick embryos through targeting TGF‐β signaling
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Cellular Physiology"
DOI: 10.1002/jcp.29707
Abstract: Folic acid (FA) is routinely supplemented in the food of pregnant women or women planning a pregnancy, but whether FA exerts a positive effect on preventing fetal bone malformation remains obscure. In this study, we… read more here.
Keywords: folic acid; dex; chick embryos; targeting tgf ... See more keywords
Absolute Quantification of TGF-β Signaling Proteins Using Quantitative Western Blot.
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DOI: 10.1007/978-1-0716-2277-3_1
Abstract: Cell signaling governs the basic functions of cells by molecular interactions that involve of many proteins. The abundance of signaling proteins can directly influence cellular responses to external signal, contributing to cellular heterogeneity. Absolute quantification… read more here.
Keywords: using quantitative; absolute quantification; proteins using; signaling proteins ... See more keywords
Exogenous GDF11 attenuates non-canonical TGF-β signaling to protect the heart from acute myocardial ischemia–reperfusion injury
Sign Up to like & getrecommendations! Published in 2019 at "Basic Research in Cardiology"
DOI: 10.1007/s00395-019-0728-z
Abstract: Growth differentiation factor 11 (GDF11) is a member of the transforming growth factor beta 1 (TGF-β1) superfamily that reverses age-related cardiac hypertrophy, improves muscle regeneration and angiogenesis, and maintains progenitor cells in injured tissue. Recently,… read more here.
Keywords: heart; reperfusion; gdf11; injury ... See more keywords