Inhibition of the prolyl isomerase Pin1 improves endothelial function and attenuates vascular remodelling in pulmonary hypertension by inhibiting TGF-β signalling.
Sign Up to like & getrecommendations! Published in 2021 at "Angiogenesis"
DOI: 10.1007/s10456-021-09812-7
Abstract: Pulmonary arterial hypertension (PAH) is a devastating disease, characterized by obstructive pulmonary vascular remodelling ultimately leading to right ventricular (RV) failure and death. Disturbed transforming growth factor-β (TGF-β)/bone morphogenetic protein (BMP) signalling, endothelial cell dysfunction,… read more here.
Keywords: vascular remodelling; tgf signalling; inhibition; bmp signalling ... See more keywords
Cytidine monophosphate kinase is inhibited by the TGF-β signalling pathway through the upregulation of miR-130b-3p in human epithelial ovarian cancer.
Sign Up to like & getrecommendations! Published in 2017 at "Cellular signalling"
DOI: 10.1016/j.cellsig.2017.04.009
Abstract: Cytidine monophosphate kinase (CMPK), a member of the nucleoside monophosphate kinase family, plays an important role in the biosynthesis of nucleoside metabolism, DNA repair and tumour development. In this study, we demonstrated for the first… read more here.
Keywords: tgf signalling; signalling pathway; expression; cmpk ... See more keywords
TGF-β signalling in tumour associated macrophages.
Sign Up to like & getrecommendations! Published in 2017 at "Immunobiology"
DOI: 10.1016/j.imbio.2015.11.016
Abstract: Tumour associated macrophages (TAM) represent an important component of tumour stroma. They develop under the influence of tumour microenvironment where transforming growth factor (TGF)β is frequently present. Activities of TAM regulated by TGFβ stimulate proliferation… read more here.
Keywords: tgf signalling; associated macrophages; tumour associated; signalling tumour ... See more keywords
Silencing of TGFβ signalling in microglia results in impaired homeostasis
Sign Up to like & getrecommendations! Published in 2018 at "Nature Communications"
DOI: 10.1038/s41467-018-06224-y
Abstract: TGFβ1 has been implicated in regulating functional aspects of several distinct immune cell populations including central nervous system (CNS) resident microglia. Activation and priming of microglia have been demonstrated to contribute to the progression of… read more here.
Keywords: homeostasis; tgf signalling; tgf; signalling microglia ... See more keywords
Cancer immunotherapy via targeted TGF-β signalling blockade in TH cells
Sign Up to like & getrecommendations! Published in 2020 at "Nature"
DOI: 10.1038/s41586-020-2850-3
Abstract: Cancer arises from malignant cells that exist in dynamic multilevel interactions with the host tissue. Cancer therapies aiming to directly kill cancer cells, including oncogene-targeted therapy and immune-checkpoint therapy that revives tumour-reactive cytotoxic T lymphocytes,… read more here.
Keywords: tgf signalling; tgf; cancer; cell ... See more keywords
Inhibition of TGF-β signalling in combination with nal-IRI plus 5-Fluorouracil/Leucovorin suppresses invasion and prolongs survival in pancreatic tumour mouse models
Sign Up to like & getrecommendations! Published in 2020 at "Scientific Reports"
DOI: 10.1038/s41598-020-59893-5
Abstract: Pancreatic ductal adenocarcinoma (PDAC) is one of the most aggressive malignancies. TGF-β is strongly expressed in both the epithelial and stromal compartments of PDAC, and dysregulation of TGF-β signalling is a frequent molecular disturbance in… read more here.
Keywords: combination; tgf signalling; pancreatic cancer; iri ... See more keywords
In the spotlight: the role of TGFβ signalling in haematopoietic stem and progenitor cell emergence
Sign Up to like & getrecommendations! Published in 2022 at "Biochemical Society Transactions"
DOI: 10.1042/bst20210363
Abstract: Haematopoietic stem and progenitor cells (HSPCs) sustain haematopoiesis by generating precise numbers of mature blood cells throughout the lifetime of an individual. In vertebrates, HSPCs arise during embryonic development from a specialised endothelial cell population,… read more here.
Keywords: haematopoietic stem; role; stem progenitor; tgf signalling ... See more keywords
SLC39A5 dysfunction impairs extracellular matrix synthesis in high myopia pathogenesis
Sign Up to like & getrecommendations! Published in 2021 at "Journal of Cellular and Molecular Medicine"
DOI: 10.1111/jcmm.16803
Abstract: High myopia is one of the leading causes of visual impairment worldwide with high heritability. We have previously identified the genetic contribution of SLC39A5 to nonsyndromic high myopia and demonstrated that disease‐related mutations of SLC39A5… read more here.
Keywords: tgf signalling; slc39a5; myopia; high myopia ... See more keywords
hsa-miR-875-5p inhibits tumorigenesis and suppresses TGF-β signalling by targeting USF2 in gastric cancer
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Translational Medicine"
DOI: 10.1186/s12967-022-03253-6
Abstract: Background Gastric cancer (GC) is one of the most common malignancies, and an increasing number of studies have shown that its pathogenesis is regulated by various miRNAs. In this study, we investigated the role of… read more here.
Keywords: migration invasion; targeting usf2; gastric cancer; tgf signalling ... See more keywords
Systems biology reveals how altered TGFβ signalling with age reduces protection against pro-inflammatory stimuli
Sign Up to like & getrecommendations! Published in 2019 at "PLoS Computational Biology"
DOI: 10.1371/journal.pcbi.1006685
Abstract: Osteoarthritis (OA) is a degenerative condition caused by dysregulation of multiple molecular signalling pathways. Such dysregulation results in damage to cartilage, a smooth and protective tissue that enables low friction articulation of synovial joints. Matrix… read more here.
Keywords: tgf signalling; age; biology; systems biology ... See more keywords
Modulators of hormonal response regulate temporal fate specification in the Drosophila brain
Sign Up to like & getrecommendations! Published in 2019 at "PLoS Genetics"
DOI: 10.1371/journal.pgen.1008491
Abstract: Neuronal diversity is at the core of the complex processing operated by the nervous system supporting fundamental functions such as sensory perception, motor control or memory formation. A small number of progenitors guarantee the production… read more here.
Keywords: hormonal response; tgf signalling; response; temporal fate ... See more keywords