KIN17 promotes cell migration and invasion through stimulating the TGF‐β/Smad2 pathway in hepatocellular carcinoma
Sign Up to like & getrecommendations! Published in 2022 at "Molecular Carcinogenesis"
DOI: 10.1002/mc.23492
Abstract: KIN17 DNA and RNA binding protein (Kin17) is involved in the regulation of tumorigenesis of diverse human cancers. However, its role in the cancer progression and metastasis in hepatocellular carcinoma (HCC) remains largely unknown. Bioinformatics… read more here.
Keywords: smad2 pathway; migration invasion; kin17; tgf smad2 ... See more keywords
Androgen receptor reverses the oncometabolite R-2-hydroxyglutarate-induced prostate cancer cell invasion via suppressing the circRNA-51217/miRNA-646/TGFβ1/p-Smad2/3 signaling.
Sign Up to like & getrecommendations! Published in 2019 at "Cancer letters"
DOI: 10.1016/j.canlet.2019.12.014
Abstract: IDH1 (Isocitrate dehydrogenase 1) mutation occurring at codon 132 (R132) in prostate cancer (PCa) is considered as a classifier for a subgroup of PCas with accumulation of oncometabolite R-2HG (R-2-hydroxyglutarate). Here we found that adding… read more here.
Keywords: tgf smad2; cell; circrna 51217; cell invasion ... See more keywords
Baihe Wuyao decoction ameliorates CCl4-induced chronic liver injury and liver fibrosis in mice through blocking TGF-β1/Smad2/3 signaling, anti-inflammation and anti-oxidation effects.
Sign Up to like & getrecommendations! Published in 2020 at "Journal of ethnopharmacology"
DOI: 10.1016/j.jep.2020.113227
Abstract: ETHNOPHARMACOLOGICAL RELEVANCE Baihe Wuyao decoction (BWD), a prescription of Traditional Chinese Medicines, composed of Lilium brownii var. viridulum Baker.(Lilii Bulbus) and Lindera aggregata (Sims) Kosterm. (Linderae Radix), has been used to treat epigastric pain and… read more here.
Keywords: tgf smad2; fibrosis; liver fibrosis; liver ... See more keywords
Guizhi Fuling pill attenuates liver fibrosis in vitro and in vivo via inhibiting TGF-β1/Smad2/3 and activating IFN-γ/Smad7 signaling pathways
Sign Up to like & getrecommendations! Published in 2022 at "Bioengineered"
DOI: 10.1080/21655979.2022.2054224
Abstract: ABSTRACT Liver fibrosis resulting from chronic liver injuries (CLI) is a common health problem globally. Guizhi Fuling pill (GZFL), a modern preparation from traditional Chinese medicine, exhibited anti-dysmenorrhea, anti-inflammatory, and immune-regulative effects. However, the effect… read more here.
Keywords: fibrosis; liver fibrosis; tgf smad2; smad7 ... See more keywords
MP84-20 EXOSOMES DERIVED FROM CORPUS CAVERNOSUM SMOOTH MUSCLE CELLS IMPROVE DIABETES-INDUCED ERECTILE DYSFUNCTION VIA ALLEVIATING FIBROSIS AND MODULATING THE TGF-Β1/SMAD2/3/CTGF SIGNALING PATHWAYS
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Urology"
DOI: 10.1097/ju.0000000000000976.020
Abstract: INTRODUCTION AND OBJECTIVE: Erectile dysfunction (ED) is one of most common complications in men with diabetes. ED in these men occurs at early age and present with severe symptoms. Besides, PDE5i, a commonly used drug… read more here.
Keywords: tgf smad2; fibrosis; smad2 ctgf; erectile dysfunction ... See more keywords
BKCa Mediates Dysfunction in High Glucose Induced Mesangial Cell Injury via TGF-β1/Smad2/3 Signaling Pathways
Sign Up to like & getrecommendations! Published in 2020 at "International Journal of Endocrinology"
DOI: 10.1155/2020/3260728
Abstract: Objective To explore the role and mechanism of BKCa in diabetic kidney disease. Methods Rat mesangial cells (MCs) HBZY-1 were cultured with high glucose to simulate the high-glucose environment of diabetic kidney disease in vivo.… read more here.
Keywords: tgf smad2; high glucose; smad2 signaling; cell ... See more keywords
miR-486-5p Restrains Extracellular Matrix Production and Oxidative Damage in Human Trabecular Meshwork Cells by Targeting TGF-β/SMAD2 Pathway
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Ophthalmology"
DOI: 10.1155/2022/3584192
Abstract: Background Glaucoma is characterized by elevated intraocular pressure caused by aqueous outflow dysfunction. Trabecular meshwork plays a key role in controlling intraocular pressure by modulating aqueous outflow. This study investigated the protective effects of miR-486-5p… read more here.
Keywords: h2o2; oxidative damage; tgf smad2; mir 486 ... See more keywords
Protein phosphatase PPM1A inhibition attenuates osteoarthritis via regulating TGF-β/Smad2 signaling in chondrocytes
Sign Up to like & getrecommendations! Published in 2023 at "JCI Insight"
DOI: 10.1172/jci.insight.166688
Abstract: TGF-β signaling is crucial for modulating osteoarthritis (OA), and protein phosphatase magnesium–dependent 1A (PPM1A) has been reported as a phosphatase of SMAD2 and regulates TGF-β signaling, while the role of PPM1A in cartilage homeostasis and… read more here.
Keywords: smad2; tgf smad2; smad2 signaling; protein phosphatase ... See more keywords
NR4A1 inhibits the epithelial–mesenchymal transition of hepatic stellate cells: Involvement of TGF-β–Smad2/3/4–ZEB signaling
Sign Up to like & getrecommendations! Published in 2022 at "Open Life Sciences"
DOI: 10.1515/biol-2022-0047
Abstract: Abstract This study aimed to examine whether nuclear receptor 4a1 (NR4A1) is involved in inhibiting hepatic stellate cell (HSC) activation and liver fibrosis through the epithelial–mesenchymal transition (EMT). HSC-T6 cells were divided into the control… read more here.
Keywords: group; tgf smad2; epithelial mesenchymal; smad2 zeb ... See more keywords
Suppression of ADAM8 attenuates angiotensin II-induced cardiac fibrosis and endothelial-mesenchymal transition via inhibiting TGF-β1/Smad2/Smad3 pathways.
Sign Up to like & getrecommendations! Published in 2021 at "Experimental animals"
DOI: 10.1538/expanim.21-0064
Abstract: Endothelial-to-mesenchymal transition (EndMT) is involved in cardiac fibrosis induced by angiotensin II (Ang II). A disintegrin and metalloproteinase 8 (ADAM8), a member of ADAMs family, participates in cell adhesion, proteolysis and various signaling. However, its… read more here.
Keywords: tgf smad2; induced cardiac; fibrosis; cardiac fibrosis ... See more keywords
Involvement of Rho-associated coiled-coil kinase signaling inhibition in TGF-β1/Smad2, 3 signal transduction in vitro.
Sign Up to like & getrecommendations! Published in 2017 at "International journal of ophthalmology"
DOI: 10.18240/ijo.2017.12.03
Abstract: AIM To research the effect of Y-27632, a selective Rho-associated coiled-coil kinase (ROCK) inhibitor, on TGF-β1/Smad2, 3 signal transduction in ocular Tenon's capsule fibroblasts (OTFs). METHODS Primary ocular Tenon's capsule fibroblasts had been cultured in… read more here.
Keywords: tgf smad2; coil kinase; rho associated; tgf ... See more keywords