Silencing lncRNA Snhg6 mitigates bleomycin‐induced pulmonary fibrosis in mice via miR‐26a‐5p/TGF‐β1‐smads axis
Sign Up to like & getrecommendations! Published in 2022 at "Environmental Toxicology"
DOI: 10.1002/tox.23603
Abstract: Idiopathic pulmonary fibrosis (IPF) is an interstitial pulmonary disease with slow onset and high mortality. Epithelial–mesenchymal transition (EMT) is a significant condition for tissue fibrosis, and lncRNA‐Snhg6 (small nucleolar RNA host gene 6) is related… read more here.
Keywords: snhg6; pulmonary fibrosis; mir 26a; fibrosis ... See more keywords
Difference of TGF-β/Smads signaling pathway in epithelial-mesenchymal transition of normal colonic epithelial cells induced by tumor-associated fibroblasts and colon cancer cells
Sign Up to like & getrecommendations! Published in 2019 at "Molecular Biology Reports"
DOI: 10.1007/s11033-019-04719-5
Abstract: Tumor microenvironment (TME) crucially functions in tumor initiation and progression. Stroma-tumor interactions and cellular transdifferentiation are the prerequisite for tumor formation. Transforming growth factor-β (TGF-β), a major cytokine secreted by tumor-associated fibroblasts (TAFs) and cancer… read more here.
Keywords: tgf smads; epithelial cells; colon; cancer cells ... See more keywords
The role of KDR in intrauterine adhesions may involve the TGF-β1/Smads signaling pathway
Sign Up to like & getrecommendations! Published in 2019 at "Brazilian Journal of Medical and Biological Research"
DOI: 10.1590/1414-431x20198324
Abstract: The aim of this study was to investigate the role of kinase-insert domain-containing receptor (KDR) in intrauterine adhesions (IUA) and its mechanism. The Case group consisted of 92 patients diagnosed with IUA, and the Control… read more here.
Keywords: expression; kdr intrauterine; kdr; intrauterine adhesions ... See more keywords
Combination of Ginsenoside Rg1 and Astragaloside IV reduces oxidative stress and inhibits TGF-β1/Smads signaling cascade on renal fibrosis in rats with diabetic nephropathy
Sign Up to like & getrecommendations! Published in 2018 at "Drug Design, Development and Therapy"
DOI: 10.2147/dddt.s171286
Abstract: Introduction Anti-oxidative stress and inhibition of TGF-β1/Smads signaling cascade are essential therapeutic strategies for diabetic nephropathy (DN). In this study, we aimed to explore the effect of combination of Ginsenoside Rg1 and Astragaloside IV on… read more here.
Keywords: ginsenoside rg1; tgf smads; group group; group ... See more keywords
rGO/Silk Fibroin-Modified Nanofibrous Patches Prevent Ventricular Remodeling via Yap/Taz-TGFβ1/Smads Signaling After Myocardial Infarction in Rats
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DOI: 10.3389/fcvm.2021.718055
Abstract: Objective: After acute myocardial infarction (AMI), the loss of cardiomyocytes and dysregulation of extracellular matrix homeostasis results in impaired cardiac function and eventually heart failure. Cardiac patches have emerged as a potential therapeutic strategy for… read more here.
Keywords: tgf smads; taz tgf; rgo silk; silk ... See more keywords
Shenkang Injection for Treating Renal Fibrosis-Metabonomics and Regulation of E3 Ubiquitin Ligase Smurfs on TGF-β/Smads Signal Transduction
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Pharmacology"
DOI: 10.3389/fphar.2022.849832
Abstract: At present, TGF-β is the most critical fibrogenic factor known. Smad ubiquitin ligase Smurfs play an important role in the regulation of the TGF-/Smads signaling pathway, which is linked to metabolite changes in renal fibrosis.… read more here.
Keywords: injection; regulation; fibrosis; tgf smads ... See more keywords