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   Articles with "tgf type" as a keyword



Design, 3D QSAR modeling and docking of TGF-β type I inhibitors to target cancer

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recommendations! Published in 2018 at "Computational biology and chemistry"

DOI: 10.1016/j.compbiolchem.2018.07.011

Abstract: Transforming growth factor-β (TGF-β) family members plays a vital role in regulating hormonal function, bone formation, tissue remodeling, and erythropoiesis, cell growth and apoptosis. TGF-β super-family members mediate signal transduction via serine/threonine kinase receptors located… read more here.

Keywords: tgf type; type inhibitors; qsar; cancer ... See more keywords

The TGFβ type I receptor kinase inhibitor vactosertib in combination with pomalidomide in relapsed/refractory multiple myeloma: a phase 1b trial

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recommendations! Published in 2024 at "Nature Communications"

DOI: 10.1038/s41467-024-51442-2

Abstract: Functional blockade of the transforming growth factor-beta (TGFβ) signalling pathway improves the efficacy of cytotoxic and immunotherapies. Here, we conducted a phase 1b study (ClinicalTrials.gov., NCT03143985) to determine the primary endpoints of safety, tolerability, and… read more here.

Keywords: tgf type; kinase inhibitor; pomalidomide; type receptor ... See more keywords

Role of human adipose-derived stem cells (hADSC) on TGF-β1, type I collagen, and fibrosis degree in bladder obstruction model of Wistar rats

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recommendations! Published in 2022 at "BMC Urology"

DOI: 10.1186/s12894-022-01019-2

Abstract: Introduction Bladder outlet obstruction (BOO) was caused by a series of histological and biochemical changes in the bladder wall, through the inflammation process in the bladder wall, hypertrophy and fibrosis. ADSC has an important role… read more here.

Keywords: type collagen; fibrosis; wistar; tgf type ... See more keywords

A TGF-β type II receptor that associates with developmental transition in Haemonchus contortus in vitro

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recommendations! Published in 2019 at "PLoS Neglected Tropical Diseases"

DOI: 10.1371/journal.pntd.0007913

Abstract: Background The TGF-β signalling pathway plays a key role in regulating dauer formation in the free-living nematode Caenorhabditis elegans, and previous work has shown that TGF-β receptors are involved in parasitic nematodes. Here, we explored… read more here.

Keywords: haemonchus contortus; tgf; tgf type; type receptor ... See more keywords