Potentiation of cancerous progression by LISCH7 via direct stimulation of TGFB1 transcription in triple‐negative breast cancer
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Cellular Biochemistry"
DOI: 10.1002/jcb.29679
Abstract: As an aggressive breast cancer (BCa) subtype, triple‐negative breast cancer (TNBC) responses poorly to chemotherapy and endocrine therapy, and usually has a worse prognosis. This is largely due to the lack of specific therapeutic targets,… read more here.
Keywords: tgfb1; cancerous progression; lisch7; breast cancer ... See more keywords
The role of IL-17 rs2275913, IL-17RC rs708567 and TGFB1 rs1800469 SNPs and IL-17A serum levels in patients with lupus nephritis
Sign Up to like & getrecommendations! Published in 2021 at "Rheumatology International"
DOI: 10.1007/s00296-021-04996-z
Abstract: Systemic lupus erythematosus (SLE) is a multifactorial autoimmune disease and polymorphisms in the cytokine genes and their receptors are thought to influence its development. The aim of this case–control study was to investigate the association… read more here.
Keywords: 17a serum; serum levels; tgfb1; rs2275913 ... See more keywords
Evidence of distinct RELN and TGFB1 genetic associations in familial and non-familial otosclerosis in a British population
Sign Up to like & getrecommendations! Published in 2018 at "Human Genetics"
DOI: 10.1007/s00439-018-1889-9
Abstract: Otosclerosis is a common form of hearing loss which typically presents in young adults. The disease has a familial, monogenic form and a non-familial form with a more complex aetiology. A previous genome wide association… read more here.
Keywords: evidence; association; otosclerosis; tgfb1 ... See more keywords
The c.29T>C polymorphism of the transforming growth factor beta-1 (TGFB1) gene, bone mineral density and the occurrence of low-energy fractures in patients with inflammatory bowel disease
Sign Up to like & getrecommendations! Published in 2017 at "Molecular Biology Reports"
DOI: 10.1007/s11033-017-4131-2
Abstract: Gastrointestinal tract conditions are frequently associated with low bone mineral density and increased risk of fractures due to osteoporosis, the latter concerning particularly inflammatory bowel disease (IBD) patients. One of the candidate genes involved in… read more here.
Keywords: bone mineral; energy; disease; tgfb1 ... See more keywords
Aberrant DNA methylation of Tgfb1 in diabetic kidney mesangial cells
Sign Up to like & getrecommendations! Published in 2018 at "Scientific Reports"
DOI: 10.1038/s41598-018-34612-3
Abstract: Epigenetic modulation may underlie the progression of diabetic nephropathy (DN). Involvement of TGFB1 in mesangial fibrosis of DN led us to hypothesize that Tgfb1 DNA demethylation contributes to progression of DN. In primary mesangial cells… read more here.
Keywords: methylation tgfb1; mesangial cells; tgfb1; aberrant dna ... See more keywords
Anti-fibrotic effects of the sirt6-activator mdl-800 in cardiac stromal cells
Sign Up to like & getrecommendations! Published in 2024 at "European Heart Journal"
DOI: 10.1093/eurheartj/ehae666.3658
Abstract: Epigenetic changes are among the molecular substrates of cellular stress responses and tissue remodeling in heart failure progression. The sirtuin family of NAD+-dependent histone and non-histone protein deacetylases exert a protective anti-fibrotic role by negatively… read more here.
Keywords: mdl 800; tgfb1 ctr; ctr fold; tgfb1 ... See more keywords
Transforming growth factor beta 1 polymorphisms and haplotypes associated with breast cancer susceptibility: A case-control study in Tunisian women
Sign Up to like & getrecommendations! Published in 2019 at "Tumor Biology"
DOI: 10.1177/1010428319869096
Abstract: Variable association of transforming growth factor beta 1 (TGFβ1) in breast cancer (BC) pathogenesis was documented, and the contribution of specific TGFB1 polymorphisms to the progression of BC and associated features remains poorly understood. We… read more here.
Keywords: transforming growth; susceptibility; factor beta; growth factor ... See more keywords