A genetic variant located in the miR-532-5p-binding site of TGFBR1 is associated with the colorectal cancer risk
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Gastroenterology"
DOI: 10.1007/s00535-018-1490-y
Abstract: BackgroundGenome-wide association studies have identified genes in the transforming growth factor-β (TGFβ) signaling pathway that are responsible for regulating carcinogenesis.MethodsWe searched for single-nucleotide polymorphisms (SNPs) located within 3′-untranslated regions (3′-UTRs) that might affect the ability… read more here.
Keywords: tgfbr1; colorectal cancer; cancer risk; mir 532 ... See more keywords
Targeting TGF beta receptor 1 in head and neck squamous cell carcinoma.
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DOI: 10.1111/odi.14594
Abstract: OBJECTIVES The transforming growth factor-Beta (TGF-ß) pathway may be involved in the radioresistance of head and neck squamous cell carcinoma (HNSCC). This study analyzed TGF-ß receptor 1 (TGFBR1) expression in HNSCC patients and evaluated the… read more here.
Keywords: cell; cell carcinoma; head neck; squamous cell ... See more keywords
Abstract 2853: TP-6379, an investigational TGFBR1 inhibitor, shows improvement in survival and enhances activity of standard of care in preclinical ovarian cancer models
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DOI: 10.1158/1538-7445.am2023-2853
Abstract: Ovarian cancer is still associated with poor prognosis and remains amongst the leading causes of cancer related deaths in females. High recurrence rates, resistance to chemotherapy, and meager outcome highlight the need for improved therapies… read more here.
Keywords: oncology; standard care; ovarian cancer; treatment ... See more keywords