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   Articles with "tgfbr2" as a keyword



A genotype to phenotype relationship of exudative vitreoretinopathy in Loeys–Dietz syndrome due to a pathogenic variant in TGFBR2

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recommendations! Published in 2025 at "Ophthalmic Genetics"

DOI: 10.1080/13816810.2025.2565633

Abstract: ABSTRACT Introduction Loeys-Dietz syndrome (LDS) is a rare autosomal dominant connective tissue disorder most commonly due to pathogenic variants in the transforming growth factor beta receptor genes TGFBR1 and TGFBR2. There have been reports of… read more here.

Keywords: variant; tgfbr2; dietz syndrome; loeys dietz ... See more keywords

The CDR1as/miR-7/TGFBR2 Axis Modulates EMT in Silica-Induced Pulmonary Fibrosis

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recommendations! Published in 2018 at "Toxicological Sciences"

DOI: 10.1093/toxsci/kfy221

Abstract: Silicosis is one of the typical forms of pneumoconiosis characterized by abnormal proliferation of fibroblasts and deposition of extracellular matrix. Recent findings have shown that microRNAs and circular RNAs (circRNAs) are implicated in many diseases.… read more here.

Keywords: tgfbr2; fibrosis; mir; silica ... See more keywords

Abstract 5009: Inhibition of TGFBR2 signaling re-sensitizes TMZ-resistant glioblastoma cells to therapy

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recommendations! Published in 2023 at "Cancer Research"

DOI: 10.1158/1538-7445.am2023-5009

Abstract: Glioblastoma (GBM), the most aggressive and lethal form of brain tumors, recurs in 90% of cases and the standard protocol of care—temozolomide (TMZ)—is an ineffective method to combat chemo-resistant GBM. It is therefore imperative that… read more here.

Keywords: inhibition tgfbr2; glioblastoma; gbm; tmz resistant ... See more keywords

Abstract 3430: TGFBR2 mediated phosphorylation of BUB1 at Ser-318 is required for transforming growth factor-β signaling

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recommendations! Published in 2019 at "Cancer Research"

DOI: 10.1158/1538-7445.sabcs18-3430

Abstract: The Ser/Thr kinase BUB1 (budding uninhibited by benzimidazoles-1) is required for efficient signaling by the TGF-β receptor. Recruitment of BUB1 to the activated heteromeric TGF-β-receptor complex including SMAD2 and SMAD3, is required for ligand mediated… read more here.

Keywords: tgfbr2 mediated; phosphorylation bub1; bub1; mediated phosphorylation ... See more keywords

CircFAM120B Blocks the Development of Colorectal Cancer by Activating TGF-Beta Receptor II Expression via Targeting miR-645

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recommendations! Published in 2021 at "Frontiers in Cell and Developmental Biology"

DOI: 10.3389/fcell.2021.682543

Abstract: Circular RNAs (circRNAs) are implicated in various human cancers, including colorectal cancer (CRC). The objective of this study was to investigate the function and regulatory mechanism of a novel circRNA, circFAM120B, in CRC development. The… read more here.

Keywords: mir 645; tgfbr2; glycolysis; targeting mir ... See more keywords

Tgfbr2 in Dental Pulp Cells Guides Neurite Outgrowth in Developing Teeth

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recommendations! Published in 2022 at "Frontiers in Cell and Developmental Biology"

DOI: 10.3389/fcell.2022.834815

Abstract: Transforming growth factor β (TGFβ) plays an important role in tooth morphogenesis and mineralization. During postnatal development, the dental pulp (DP) mesenchyme secretes neurotrophic factors that guide trigeminal nerve fibers into and throughout the DP.… read more here.

Keywords: tgfbr2; mineralization; dental pulp; neurite outgrowth ... See more keywords

Loss of Function TGFBR2 Variant as a Contributing Factor in Generalized Pustular Psoriasis and Adult-Onset Immunodeficiency

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recommendations! Published in 2022 at "Genes"

DOI: 10.3390/genes14010103

Abstract: Background: Generalized pustular psoriasis (GPP; MIM 614204) is a rare multisystemic autoinflammatory disease, characterized by episodes of acute generalized erythema and scaling developed with the spread of numerous sterile pustules. Adult-onset immunodeficiency syndrome (AOID) with… read more here.

Keywords: adult onset; generalized pustular; tgfbr2; immunodeficiency ... See more keywords

MiR-301b-3p promotes breast cancer development through inhibiting the expression of transforming growth factor-beta receptor 2

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recommendations! Published in 2024 at "PeerJ"

DOI: 10.7717/peerj.18324

Abstract: Background Breast cancer (BC) is a serious health threat to the patients. The present work explored the mechanism of miR-301b-3p and transforming growth factor-beta receptor 2 (TGFBR2 ) in affecting BC progression. Methods The miR-301b-3p-inhibitor… read more here.

Keywords: tgfbr2; mir 301b; cell; expression ... See more keywords