TGIF1-Twist1 axis in pancreatic ductal adenocarcinoma
Sign Up to like & getrecommendations! Published in 2020 at "Computational and Structural Biotechnology Journal"
DOI: 10.1016/j.csbj.2020.09.023
Abstract: TG-interacting factor 1 (TGIF1) exerts inhibitory effects on transforming growth factor-beta (TGF-β) signaling by suppressing Smad signaling pathway at multiple levels. TGIF1 activity is important for normal embryogenesis and organogenesis, yet its dysregulation can culminate… read more here.
Keywords: tgif1 twist1; tgif1; twist1; pancreatic ductal ... See more keywords
TGIF1 homeodomain interacts with Smad MH1 domain and represses TGF-β signaling
Sign Up to like & getrecommendations! Published in 2018 at "Nucleic Acids Research"
DOI: 10.1093/nar/gky680
Abstract: Abstract TGIF1 is a multifunctional protein that represses TGF-β-activated transcription by interacting with Smad2-Smad4 complexes. We found that the complex structure of TGIF1–HD bound to the TGACA motif revealed a combined binding mode that involves… read more here.
Keywords: dna; tgif1; represses tgf; mh1 domain ... See more keywords