Sohlh2 Promotes the Progression of Hepatocellular Carcinoma via TGM2‐Mediated Autophagy
Sign Up to like & getrecommendations! Published in 2024 at "Molecular Carcinogenesis"
DOI: 10.1002/mc.23832
Abstract: Liver cancer is the third leading cause of cancer‐related deaths worldwide, with hepatocellular carcinoma (HCC) accounting for 85% of liver cancer‐related deaths. Autophagy controls HCC cell growth, invasion, metastasis, drug resistance, and stemness. Spermatogenesis and… read more here.
Keywords: tgm2; hcc; via tgm2; hepatocellular carcinoma ... See more keywords
SDC1-dependent TGM2 determines radiosensitivity in glioblastoma by coordinating EPG5-mediated fusion of autophagosomes with lysosomes
Sign Up to like & getrecommendations! Published in 2022 at "Autophagy"
DOI: 10.1080/15548627.2022.2105562
Abstract: ABSTRACT Glioblastoma multiforme (GBM) is the most common brain malignancy insensitive to radiotherapy (RT). Although macroautophagy/autophagy was reported to be a fundamental factor prolonging the survival of tumors under radiotherapeutic stress, the autophagic biomarkers coordinated… read more here.
Keywords: fusion autophagosomes; tgm2; autophagosomes lysosomes; gbm ... See more keywords
Microglial transglutaminase 2 deficiency causes impaired synaptic remodelling and cognitive deficits in mice.
Sign Up to like & getrecommendations! Published in 2023 at "Cell proliferation"
DOI: 10.1111/cpr.13439
Abstract: Microglia are the primary source of transglutaminase 2 (TGM2) in the brain; however, the roles of microglial TGM2 in neural development and disease are still not well known. The aim of this study is to… read more here.
Keywords: impaired synaptic; cognitive deficits; deficits mice; causes impaired ... See more keywords
Deletion of Tgm2 suppresses BMP‐mediated hepatocyte‐to‐cholangiocyte metaplasia in ductular reaction
Sign Up to like & getrecommendations! Published in 2024 at "Cell Proliferation"
DOI: 10.1111/cpr.13646
Abstract: Transglutaminase 2 (Tgm2) plays an essential role in hepatic repair following prolonged toxic injury. During cholestatic liver injury, the intrahepatic cholangiocytes undergo dynamic tissue expansion and remodelling, referred to as ductular reaction (DR), which is… read more here.
Keywords: tgm2; deletion tgm2; culture; metaplasia ... See more keywords
Unique characteristics of lung resident neutrophils are maintained by PGE2/PKA/Tgm2-mediated signaling.
Sign Up to like & getrecommendations! Published in 2022 at "Blood"
DOI: 10.1182/blood.2021014283
Abstract: Lung resident neutrophils need to be tightly regulated to avoid degranulation-and cytokine-associated damage to fragile alveolar structures that can lead to fatal outcomes. Here we show that lung neutrophils (LNs) express distinct surface proteins and… read more here.
Keywords: unique characteristics; resident neutrophils; characteristics lung; lung resident ... See more keywords
Circular RNA circ_0081001 knockdown enhances methotrexate sensitivity in osteosarcoma cells by regulating miR-494-3p/TGM2 axis
Sign Up to like & getrecommendations! Published in 2021 at "Journal of Orthopaedic Surgery and Research"
DOI: 10.1186/s13018-020-02169-5
Abstract: Background Circular RNAs (circRNAs) have been shown to participate in the chemoresistance and tumorigenesis of multiple cancers. The purpose of this research was to investigate the function of circ_0081001 in methotrexate (MTX) resistance of osteosarcoma… read more here.
Keywords: tgm2; mir 494; 0081001 knockdown; circ 0081001 ... See more keywords
Genomic variants reveal differential evolutionary constraints on human transglutaminases and point towards unrecognized significance of transglutaminase 2
Sign Up to like & getrecommendations! Published in 2017 at "PLoS ONE"
DOI: 10.1371/journal.pone.0172189
Abstract: Transglutaminases (TGMs) catalyze Ca2+-dependent transamidation of proteins with specified roles in blood clotting (F13a) and in cornification (TGM1, TGM3). The ubiquitous TGM2 has well described enzymatic and non-enzymatic functions but in-spite of numerous studies its… read more here.
Keywords: reveal differential; tgm2; human transglutaminases; genomic variants ... See more keywords
TGM2 inhibits the proliferation, migration and tumorigenesis of MDCK cells
Sign Up to like & getrecommendations! Published in 2023 at "PLOS ONE"
DOI: 10.1371/journal.pone.0285136
Abstract: Madin-Darby canine kidney (MDCK) cells are one of the main cell lines used for influenza vaccine production due to their high virus yield and low mutation resistance. Due to their high tumorigenicity, the safety of… read more here.
Keywords: mdck cells; tumorigenesis; proliferation; mdck ... See more keywords
Transglutaminase 2 Regulates Self-renewal and Stem Cell Marker of Human Colorectal Cancer Stem Cells.
Sign Up to like & getrecommendations! Published in 2018 at "Anticancer research"
DOI: 10.21873/anticanres.12285
Abstract: BACKGROUND/AIM The aim of this study was to investigate the role of transglutaminase 2 (TGM2) in colorectal cancer stem cells (CCSCs). MATERIALS AND METHODS We used the TU12 cell line possessing CD133-expressing CCSCs. After isolating… read more here.
Keywords: cancer stem; tgm2; colorectal cancer; stem ... See more keywords
497-P: Fyn-Dependent Tyrosine Phosphorylation of Tgm2 Modulates p53-Tgm2-p62 Complex in Renal Proximal Tubular Epithelial Cells
Sign Up to like & getrecommendations! Published in 2019 at "Diabetes"
DOI: 10.2337/db19-497-p
Abstract: Diabetic kidney disease (DKD) is one of the major diabetic complications, the leading cause of the end stage renal disease (ESRD). Recently autophagy, which is also implicated in diabetes and insulin resistance, was shown to… read more here.
Keywords: p62; tgm2; hk2 cells; fyn ... See more keywords
TGM2 regulated by transcription factor NR3C1 drives p38 MAPK-mediated tumor progression and immune evasion in lung squamous cell carcinoma
Sign Up to like & getrecommendations! Published in 2025 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2025.1595907
Abstract: Background Lung squamous cell carcinoma (LUSC) is highly malignant with limited therapeutic targets. Prior studies indicate transglutaminase 2 (TGM2) regulates the tumor microenvironment, but its mechanisms in driving LUSC progression and immune evasion remain unclear.… read more here.
Keywords: tgm2; progression; p38 mapk; factor ... See more keywords