Documenting an epidemic of suffering: low health-related quality of life among transgender youth
Sign Up to like & getrecommendations! Published in 2018 at "Quality of Life Research"
DOI: 10.1007/s11136-018-1839-y
Abstract: PurposeTo quantify HRQOL of TGN patients using the PedsQL 4.0 generic core scales, and to compare reported HRQOL of TGN adolescents with published data from comparison populations.MethodsTransgender children and adolescents (N = 142; 68% natal females) ages… read more here.
Keywords: tgn; rheumatology; youth; hrqol ... See more keywords
Microglia in the Primary Somatosensory Barrel Cortex Mediate Trigeminal Neuropathic Pain
Sign Up to like & getrecommendations! Published in 2019 at "Neuroscience"
DOI: 10.1016/j.neuroscience.2019.05.034
Abstract: Trigeminal neuropathic pain (TGN) is an attacking, abrupt, electric-shock headache involving abnormal cortical activity. The neural mechanism underlying TGN remains elusive. In this study, we explored the role of microglia in the primary somatosensory barrel… read more here.
Keywords: primary somatosensory; tgn; microglia primary; neuropathic pain ... See more keywords
Internalized TSH receptors en route to the TGN induce local Gs-protein signaling and gene transcription
Sign Up to like & getrecommendations! Published in 2017 at "Nature Communications"
DOI: 10.1038/s41467-017-00357-2
Abstract: A new paradigm of G-protein-coupled receptor (GPCR) signaling at intracellular sites has recently emerged, but the underlying mechanisms and functional consequences are insufficiently understood. Here, we show that upon internalization in thyroid cells, endogenous TSH… read more here.
Keywords: protein; tsh receptors; local protein; gene transcription ... See more keywords
Characterization of ATP7A missense mutants suggests a correlation between intracellular trafficking and severity of Menkes disease
Sign Up to like & getrecommendations! Published in 2017 at "Scientific Reports"
DOI: 10.1038/s41598-017-00618-6
Abstract: Menkes disease (MD) is caused by mutations in ATP7A, encoding a copper-transporting P-type ATPase which exhibits copper-dependent trafficking. ATP7A is found in the Trans-Golgi Network (TGN) at low copper concentrations, and in the post-Golgi compartments… read more here.
Keywords: atp7a; tgn; copper; atp7a missense ... See more keywords
Complications of Endoscope-Assisted Microvascular Decompression for Trigeminal Neuralgia- An Evaluation of 300 Consecutive Patients
Sign Up to like & getrecommendations! Published in 2019 at "Neurosurgery"
DOI: 10.1093/neuros/nyz310_448
Abstract: Trigeminal Neuralgia (TGN) is a horrific facial pain disorder that is paroxysmal, stabbing, shooting pain that affects the face due to compression of the trigeminal nerve. Literature has suggested that the use of an endoscope… read more here.
Keywords: rates adverse; trigeminal neuralgia; adverse events; tgn ... See more keywords
Relationship Between Thiopurine S-Methyltransferase Genotype/Phenotype and 6-Thioguanine Nucleotide Levels in 316 Patients With Inflammatory Bowel Disease on 6-Thioguanine
Sign Up to like & getrecommendations! Published in 2021 at "Therapeutic Drug Monitoring"
DOI: 10.1097/ftd.0000000000000869
Abstract: Background: In inflammatory bowel disease (IBD), conventional thiopurine users cease treatment in 60% of cases within 5 years, mostly because of adverse events or nonresponse. In this study, the authors aimed to investigate the role… read more here.
Keywords: inflammatory bowel; thioguanine nucleotide; thioguanine; thiopurine methyltransferase ... See more keywords
Rab7 palmitoylation is required for efficient endosome-to-TGN trafficking
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Cell Science"
DOI: 10.1242/jcs.199729
Abstract: ABSTRACT Retromer is a multimeric protein complex that mediates endosome-to-trans-Golgi network (TGN) and endosome-to-plasma membrane trafficking of integral membrane proteins. Dysfunction of this complex has been linked to Alzheimer's disease and Parkinson's disease. The recruitment… read more here.
Keywords: endosome tgn; palmitoylation; tgn trafficking; efficient endosome ... See more keywords