Inhibition of Aquaporin 4 Decreases Amyloid Aβ40 Drainage Around Cerebral Vessels
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DOI: 10.1007/s12035-020-02044-8
Abstract: Aquaporin-4 (AQP4) is located mainly in the astrocytic end-feet around cerebral blood vessels and regulates ion and water homeostasis in the brain. While deletion of AQP4 is shown to reduce amyloid-β (Aβ) clearance and exacerbate… read more here.
Keywords: inhibition aquaporin; aquaporin decreases; clearance; around cerebral ... See more keywords
TGN‐020 alleviates edema and inhibits astrocyte activation and glial scar formation after spinal cord compression injury in rats
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DOI: 10.1016/j.lfs.2019.03.007
Abstract: Aims: Identifying drugs that inhibit edema and glial scar formation and increase neuronal survival is crucial to improving outcomes after spinal cord injury (SCI). Here, we used 2‐(nicotinamide)‐1,3,4‐thiadiazole (TGN‐020), a potent selective inhibitor of aquaporin… read more here.
Keywords: glial scar; spinal cord; scar formation; tgn 020 ... See more keywords
Alleviation of brain injury by applying TGN-020 in the supraoptic nucleus via inhibiting vasopressin neurons in rats of focal ischemic stroke.
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DOI: 10.1016/j.lfs.2020.118683
Abstract: AIMS To understand mechanisms underlying vasopressin hypersecretion in stroke and its association with brain injury, we investigated effects of blocking aquaporin 4 (AQP4) in the supraoptic nucleus (SON) on vasopressin neuronal activity and cerebral injuries… read more here.
Keywords: vasopressin neurons; brain injury; son; tgn 020 ... See more keywords
Acutely Inhibiting AQP4 With TGN-020 Improves Functional Outcome by Attenuating Edema and Peri-Infarct Astrogliosis After Cerebral Ischemia
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2022.870029
Abstract: Background Ischemic stroke is one of the leading causes of human death and disability. Brain edema and peri-infarct astrocyte reactivity are crucial pathological changes, both involving aquaporin-4 (AQP4). Studies revealed that acute inhibition of AQP4… read more here.
Keywords: tgn 020; brain; peri infarct; aqp4 ... See more keywords