Mutation of the TGN1412 anti-CD28 Monoclonal Antibody Lower Hinge Confers Specific FcγRIIb Binding and Retention of Super-Agonist Activity.
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DOI: 10.1111/imcb.12646
Abstract: The agonistic action of several immunomodulatory monoclonal antibodies (mAb) requires both target antigen binding and clustering of this mAb:target complex by the Fcs interacting with Fcγ receptors (FcγR), in particular FcγRIIb, on neighbouring bystander cells.… read more here.
Keywords: igg4; tgn1412 anti; anti cd28; mutation ... See more keywords