TGR5 agonist ameliorates insulin resistance in the skeletal muscles and improves glucose homeostasis in diabetic mice.
Sign Up to like & getrecommendations! Published in 2019 at "Metabolism: clinical and experimental"
DOI: 10.1016/j.metabol.2019.07.003
Abstract: BACKGROUND AND PURPOSE TGR5 plays an important role in many physiological processes. However, the functions of TGR5 in the regulation of the glucose metabolism and insulin sensitivity in the skeletal muscles have not been fully… read more here.
Keywords: insulin; tgr5 agonist; skeletal muscles; insulin resistance ... See more keywords
Bariatric surgery reveals a gut-restricted TGR5 agonist with anti-diabetic effects
Sign Up to like & getrecommendations! Published in 2020 at "Nature chemical biology"
DOI: 10.1038/s41589-020-0604-z
Abstract: Bariatric surgery, the most effective treatment for obesity and type 2 diabetes, is associated with increased levels of the incretin hormone glucagon-like peptide-1 (GLP-1) and changes in levels of circulating bile acids. The levels of… read more here.
Keywords: gut restricted; surgery; tgr5 agonist; ca7s ... See more keywords