Functionally distinct IFN‐γ+IL‐17A+ Th cells in experimental autoimmune uveitis: T‐cell heterogeneity, migration, and steroid response
Sign Up to like & getrecommendations! Published in 2020 at "European Journal of Immunology"
DOI: 10.1002/eji.202048616
Abstract: Immunopathogenic roles for both Th1 (CD4+IFN‐γ+) and Th17 (CD4+IL‐17A+) cells have been demonstrated in experimental autoimmune uveitis (EAU). However, the role for Th17/Th1 (CD4+ T cells co‐expressing IFN‐γ and IL‐17A) cells in EAU is not… read more here.
Keywords: th17 th1; th1 cells; th1; migration ... See more keywords
Th17 lymphocyte‐dependent degradation of joint cartilage by synovial fibroblasts in a humanized mouse model of arthritis and reversal by secukinumab
Sign Up to like & getrecommendations! Published in 2020 at "European Journal of Immunology"
DOI: 10.1002/eji.202048773
Abstract: How T‐helper (Th) lymphocyte subpopulations identified in synovial fluid from patients with juvenile idiopathic arthritis (JIA) (Th17, classic Th1, or nonclassic Th1) drive joint damage is of great interest for the possible use of biological… read more here.
Keywords: degradation; sfbs; th1; model ... See more keywords
Dysregulated Th1 cells in lung squamous cell carcinoma
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Leukocyte Biology"
DOI: 10.1002/jlb.1ma0422-208r
Abstract: Lung squamous cell carcinoma (LUSC) is a common subtype of lung cancer. Th1 cells contribute to antitumor immune responses. However, there are few studies on Th1 cells in LUSC. CD8+ T cells are the main… read more here.
Keywords: cell carcinoma; th1; th1 cells; squamous cell ... See more keywords
Immunoregulatory Effects of Silymarin on Proliferation and Activation of Th1 Cells Isolated from Newly Diagnosed and IFN-ß1b-Treated MS Patients
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DOI: 10.1007/s10753-018-0872-x
Abstract: Multiple sclerosis (MS) is a central nervous system autoimmune disease characterized by demyelination. Autoreactive T cells mainly interferon gamma (IFN-γ) producing T helper cells (Th1) have an important role in MS pathogenesis. Silymarin is a… read more here.
Keywords: th1 cells; newly diagnosed; diagnosed ifn; th1 ... See more keywords
Why Is Hormone Therapy Successful Strategy Against Coronavirus-19?
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DOI: 10.1007/s13337-021-00711-5
Abstract: Dear editor, According to information obtained from different countries about covid-19, the gender factor is influential and means that it can be a dangerous and effective factor in the incidence or mortality of this disease… read more here.
Keywords: hormone; th1; covid; immune system ... See more keywords
Protein expression profile of Taenia crassiceps cysticerci related to Th1- and Th2-type responses in the mouse cysticercosis model.
Sign Up to like & getrecommendations! Published in 2020 at "Acta Tropica"
DOI: 10.1016/j.actatropica.2020.105696
Abstract: Abstract The intraperitoneal cysticercosis model with the Taenia crassiceps ORF strain in female BALB/cAnN mice has been widely used to study the immune response in cysticercosis. During early infection (2 weeks), the host develops a… read more here.
Keywords: expression; response; cysticercosis model; th2 ... See more keywords
Protein translocation and retro-translocation across the endoplasmic reticulum are crucial to inflammatory effector CD4+ T cell function.
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DOI: 10.1016/j.cyto.2019.154944
Abstract: Effector CD4+ T cells can be classified by the cytokines they secrete, with T helper 1 (Th1) cells generating interferon (IFN)γ and Th17 cells secreting interleukin (IL)-17. Both Th1 and Th17 cells are strongly implicated… read more here.
Keywords: th1; translocation; function; cd4 cell ... See more keywords
Th1 concomitant immune response mediated by IFN-γ protects against sand fly delivered Leishmania infection: Implications for vaccine design.
Sign Up to like & getrecommendations! Published in 2020 at "Cytokine"
DOI: 10.1016/j.cyto.2020.155247
Abstract: Leishmaniasis is an unresolved global health problem with a high socio-economic impact. Data generated in mouse models has revealed that the Th1 response, with IL-12, IFN-γ, TNF-α, and IL-2 as prominent cytokines, predominantly controls the… read more here.
Keywords: sand fly; fly delivered; response; infection ... See more keywords
Persistent expansion and Th1-like skewing of HIV-specific circulating T follicular helper cells during antiretroviral therapy
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DOI: 10.1016/j.ebiom.2020.102727
Abstract: Background Untreated HIV infection leads to alterations in HIV-specific CD4+ T cells including increased expression of co-inhibitory receptors (IRs) and skewing toward a T follicular helper cell (Tfh) signature. However, which changes are maintained after… read more here.
Keywords: antiretroviral therapy; ctfh; hiv; th1 ... See more keywords
Physiological low-dose oestrogen promotes the development of experimental autoimmune thyroiditis through the up-regulation of Th1/Th17 responses.
Sign Up to like & getrecommendations! Published in 2018 at "Journal of reproductive immunology"
DOI: 10.1016/j.jri.2018.02.001
Abstract: Previous studies have reported a preponderance of autoimmune thyroiditis (AIT) in females, but the detailed mechanisms have not been elucidated. In this study, we explored the effects of oestrogen on experimental AIT (EAT) and its… read more here.
Keywords: regulation th1; low dose; autoimmune thyroiditis; th1 ... See more keywords
The potential use of gene expression profile to identify useful biomarkers for the diagnosis and the treatment of pediatric inflammatory bowel diseases
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DOI: 10.1038/s41390-019-0732-x
Abstract: Inflammatory bowel disease (IBD) are characterized by a chronic course requiring a lifelong treatment, and an overall 25% of cases are diagnosed in the childhood. Both the adaptive and the innate immune systems are involved… read more here.
Keywords: bowel; th17 cells; th1; expression ... See more keywords