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   Articles with "th1 cells" as a keyword



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Functionally distinct IFN‐γ+IL‐17A+ Th cells in experimental autoimmune uveitis: T‐cell heterogeneity, migration, and steroid response

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recommendations! Published in 2020 at "European Journal of Immunology"

DOI: 10.1002/eji.202048616

Abstract: Immunopathogenic roles for both Th1 (CD4+IFN‐γ+) and Th17 (CD4+IL‐17A+) cells have been demonstrated in experimental autoimmune uveitis (EAU). However, the role for Th17/Th1 (CD4+ T cells co‐expressing IFN‐γ and IL‐17A) cells in EAU is not… read more here.

Keywords: th17 th1; th1 cells; th1; migration ... See more keywords

Oligodendrocytes regulate the adhesion molecule ICAM-1 in neuroinflammation.

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recommendations! Published in 2021 at "Glia"

DOI: 10.1002/glia.24120

Abstract: Recently, oligodendrocytes (Ol) have been attributed potential immunomodulatory effects. Yet, the exact mode of interaction with pathogenic CNS infiltrating lymphocytes remains unclear. Here, we attempt to dissect mechanisms of Ol modulation during neuroinflammation and characterize… read more here.

Keywords: th1 cells; oligodendrocytes regulate; neuroinflammation; adhesion ... See more keywords
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Curcumin converts Foxp3+ regulatory T cells to T helper 1 cells in patients with lung cancer

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recommendations! Published in 2018 at "Journal of Cellular Biochemistry"

DOI: 10.1002/jcb.26302

Abstract: The regulatory T cells (Treg) play an important role in the tumor tolerance. The methods to regulate the Treg population in cancer‐bearing hosts are limited currently. The effect of curcumin on inhibiting cancer has been… read more here.

Keywords: th1 cells; regulatory cells; helper cells; lung cancer ... See more keywords

Dysregulated Th1 cells in lung squamous cell carcinoma

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recommendations! Published in 2022 at "Journal of Leukocyte Biology"

DOI: 10.1002/jlb.1ma0422-208r

Abstract: Lung squamous cell carcinoma (LUSC) is a common subtype of lung cancer. Th1 cells contribute to antitumor immune responses. However, there are few studies on Th1 cells in LUSC. CD8+ T cells are the main… read more here.

Keywords: cell carcinoma; th1; th1 cells; squamous cell ... See more keywords
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Malt1 inactivation attenuates experimental colitis through the regulation of Th17 and Th1/17 cells

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recommendations! Published in 2018 at "Inflammation Research"

DOI: 10.1007/s00011-018-1207-y

Abstract: Objective and designProtease activity of MALT lymphoma-translocation protein 1 (Malt1) plays an important role in the development of colitis, but the detailed mechanism has not been fully elucidated.MethodEffects of Malt1 protease on the activation of… read more here.

Keywords: th17 th1; th1 cells; malt1; colitis ... See more keywords

Immunoregulatory Effects of Silymarin on Proliferation and Activation of Th1 Cells Isolated from Newly Diagnosed and IFN-ß1b-Treated MS Patients

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recommendations! Published in 2018 at "Inflammation"

DOI: 10.1007/s10753-018-0872-x

Abstract: Multiple sclerosis (MS) is a central nervous system autoimmune disease characterized by demyelination. Autoreactive T cells mainly interferon gamma (IFN-γ) producing T helper cells (Th1) have an important role in MS pathogenesis. Silymarin is a… read more here.

Keywords: th1 cells; newly diagnosed; diagnosed ifn; th1 ... See more keywords

PD‐1 Inhibitory Receptor Downregulates Asparaginyl Endopeptidase and Maintains Foxp3 Transcription Factor Stability in Induced Regulatory T Cells

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recommendations! Published in 2018 at "Immunity"

DOI: 10.1016/j.immuni.2018.05.006

Abstract: SUMMARY CD4+ T cell differentiation into multiple T helper (Th) cell lineages is critical for optimal adaptive immune responses. This report identifies an intrinsic mechanism by which programmed death‐1 receptor (PD‐1) signaling imparted regulatory phenotype… read more here.

Keywords: th1 cells; aep; asparaginyl endopeptidase; itreg cells ... See more keywords

Platelet glutamate uptake and Th1 cells inversely correlate in relapsing/remitting and in progressive multiple sclerosis.

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recommendations! Published in 2020 at "Multiple sclerosis and related disorders"

DOI: 10.1016/j.msard.2020.102007

Abstract: BACKGROUND High affinity sodium-dependent Excitatory Amino Acid Transporters (EAAT), present in glial and neuron cells, clear around 90% of the synaptic cleft released glutamate, and their impaired activity seem to be critical for many neurodegenerative… read more here.

Keywords: glutamate uptake; platelet glutamate; multiple sclerosis; th1 cells ... See more keywords

P470 Crohn’s disease patients with Ustekinumab-induced remission are characterized by high baseline p35 cytokines subunits in LPMC and high IL-23 receptor expression in the lamina propria Th1 cells

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recommendations! Published in 2024 at "Journal of Crohn's and Colitis"

DOI: 10.1093/ecco-jcc/jjad212.0600

Abstract: Crohn’s disease (CD) is a chronic relapsing disorder of the gastrointestinal tract characterized by excessive inflammation sustained by the induction and expansion of Th1 and Th17 cells. Ustekinumab (UST), a fully humanized monoclonal antibody, is… read more here.

Keywords: disease; p35; th1; cytokines subunits ... See more keywords

Reprogramming of Th1 cells into regulatory T cells through rewiring of the metabolic status

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recommendations! Published in 2018 at "International Immunology"

DOI: 10.1093/intimm/dxy043

Abstract: T helper type 1 (Th1) cells form one of the most stable CD4 T-cell subsets, and direct conversion of fully differentiated Th1 to regulatory T (Treg) cells has been poorly investigated. Here, we established a… read more here.

Keywords: reprogramming th1; th1reg cells; th1 cells; regulatory cells ... See more keywords

CCR5 mediates rheumatoid arthritis progression by promoting the activation and proliferation of non‐classical Th1 cells

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recommendations! Published in 2024 at "International Journal of Rheumatic Diseases"

DOI: 10.1111/1756-185x.15370

Abstract: Rheumatoid arthritis (RA) is a prevalent autoimmune disease characterized by immune dysegulation, including an immune imbalance due to abnormal activation of non‐classical Th1 cells (CD161+ Th1). This study investigated the effects of CCR5 on the… read more here.

Keywords: classical th1; th1; non classical; activation ... See more keywords