Functionally distinct IFN‐γ+IL‐17A+ Th cells in experimental autoimmune uveitis: T‐cell heterogeneity, migration, and steroid response
Sign Up to like & getrecommendations! Published in 2020 at "European Journal of Immunology"
DOI: 10.1002/eji.202048616
Abstract: Immunopathogenic roles for both Th1 (CD4+IFN‐γ+) and Th17 (CD4+IL‐17A+) cells have been demonstrated in experimental autoimmune uveitis (EAU). However, the role for Th17/Th1 (CD4+ T cells co‐expressing IFN‐γ and IL‐17A) cells in EAU is not… read more here.
Keywords: th17 th1; th1 cells; th1; migration ... See more keywords
Oligodendrocytes regulate the adhesion molecule ICAM-1 in neuroinflammation.
Sign Up to like & getrecommendations! Published in 2021 at "Glia"
DOI: 10.1002/glia.24120
Abstract: Recently, oligodendrocytes (Ol) have been attributed potential immunomodulatory effects. Yet, the exact mode of interaction with pathogenic CNS infiltrating lymphocytes remains unclear. Here, we attempt to dissect mechanisms of Ol modulation during neuroinflammation and characterize… read more here.
Keywords: th1 cells; oligodendrocytes regulate; neuroinflammation; adhesion ... See more keywords
Curcumin converts Foxp3+ regulatory T cells to T helper 1 cells in patients with lung cancer
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Cellular Biochemistry"
DOI: 10.1002/jcb.26302
Abstract: The regulatory T cells (Treg) play an important role in the tumor tolerance. The methods to regulate the Treg population in cancer‐bearing hosts are limited currently. The effect of curcumin on inhibiting cancer has been… read more here.
Keywords: th1 cells; regulatory cells; helper cells; lung cancer ... See more keywords
Dysregulated Th1 cells in lung squamous cell carcinoma
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Leukocyte Biology"
DOI: 10.1002/jlb.1ma0422-208r
Abstract: Lung squamous cell carcinoma (LUSC) is a common subtype of lung cancer. Th1 cells contribute to antitumor immune responses. However, there are few studies on Th1 cells in LUSC. CD8+ T cells are the main… read more here.
Keywords: cell carcinoma; th1; th1 cells; squamous cell ... See more keywords
Malt1 inactivation attenuates experimental colitis through the regulation of Th17 and Th1/17 cells
Sign Up to like & getrecommendations! Published in 2018 at "Inflammation Research"
DOI: 10.1007/s00011-018-1207-y
Abstract: Objective and designProtease activity of MALT lymphoma-translocation protein 1 (Malt1) plays an important role in the development of colitis, but the detailed mechanism has not been fully elucidated.MethodEffects of Malt1 protease on the activation of… read more here.
Keywords: th17 th1; th1 cells; malt1; colitis ... See more keywords
Immunoregulatory Effects of Silymarin on Proliferation and Activation of Th1 Cells Isolated from Newly Diagnosed and IFN-ß1b-Treated MS Patients
Sign Up to like & getrecommendations! Published in 2018 at "Inflammation"
DOI: 10.1007/s10753-018-0872-x
Abstract: Multiple sclerosis (MS) is a central nervous system autoimmune disease characterized by demyelination. Autoreactive T cells mainly interferon gamma (IFN-γ) producing T helper cells (Th1) have an important role in MS pathogenesis. Silymarin is a… read more here.
Keywords: th1 cells; newly diagnosed; diagnosed ifn; th1 ... See more keywords
PD‐1 Inhibitory Receptor Downregulates Asparaginyl Endopeptidase and Maintains Foxp3 Transcription Factor Stability in Induced Regulatory T Cells
Sign Up to like & getrecommendations! Published in 2018 at "Immunity"
DOI: 10.1016/j.immuni.2018.05.006
Abstract: SUMMARY CD4+ T cell differentiation into multiple T helper (Th) cell lineages is critical for optimal adaptive immune responses. This report identifies an intrinsic mechanism by which programmed death‐1 receptor (PD‐1) signaling imparted regulatory phenotype… read more here.
Keywords: th1 cells; aep; asparaginyl endopeptidase; itreg cells ... See more keywords
Platelet glutamate uptake and Th1 cells inversely correlate in relapsing/remitting and in progressive multiple sclerosis.
Sign Up to like & getrecommendations! Published in 2020 at "Multiple sclerosis and related disorders"
DOI: 10.1016/j.msard.2020.102007
Abstract: BACKGROUND High affinity sodium-dependent Excitatory Amino Acid Transporters (EAAT), present in glial and neuron cells, clear around 90% of the synaptic cleft released glutamate, and their impaired activity seem to be critical for many neurodegenerative… read more here.
Keywords: glutamate uptake; platelet glutamate; multiple sclerosis; th1 cells ... See more keywords
Reprogramming of Th1 cells into regulatory T cells through rewiring of the metabolic status
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DOI: 10.1093/intimm/dxy043
Abstract: T helper type 1 (Th1) cells form one of the most stable CD4 T-cell subsets, and direct conversion of fully differentiated Th1 to regulatory T (Treg) cells has been poorly investigated. Here, we established a… read more here.
Keywords: reprogramming th1; th1reg cells; th1 cells; regulatory cells ... See more keywords
OP0196 IMBALANCE BETWEEN MEMORY TH1 AND TH1-TREG CELLS DEPENDS ON DIFFERENTIAL REGULATION OF CELL METABOLISM IN PATIENTS WITH SLE
Sign Up to like & getrecommendations! Published in 2019 at "Annals of the Rheumatic Diseases"
DOI: 10.1136/annrheumdis-2019-eular.3409
Abstract: Background T helper 1 (Th1) cells play an important role in Systemic Lupus Erythematosus (SLE). However, which abnormalities generated in Th1 cells may be related to the pathogenesis of SLE remains elusive. “Immunometabolism” has recently… read more here.
Keywords: treg cells; th1 cells; th1 treg; th1 ... See more keywords
Syntenin-1-mediated arthritogenicity is advanced by reprogramming RA metabolic macrophages and Th1 cells
Sign Up to like & getrecommendations! Published in 2023 at "Annals of the Rheumatic Diseases"
DOI: 10.1136/ard-2022-223284
Abstract: Objectives Syntenin-1, a novel endogenous ligand, was discovered to be enriched in rheumatoid arthritis (RA) specimens compared with osteoarthritis synovial fluid and normal synovial tissue (ST). However, the cellular origin, immunoregulation and molecular mechanism of… read more here.
Keywords: syntenin mediated; arthritogenicity advanced; syntenin; th1 cells ... See more keywords