Musculin inhibits human T‐helper 17 cell response to interleukin 2 by controlling STAT5B activity
Sign Up to like & getrecommendations! Published in 2017 at "European Journal of Immunology"
DOI: 10.1002/eji.201746996
Abstract: We recently demonstrated that human T‐helper (Th) 17 cells, unlike Th1 cells, do not proliferate in response to T‐cell receptor stimulation, mainly because of their reduced capacity to produce and respond to IL‐2. In this… read more here.
Keywords: response; human helper; th17 cells; th17 ... See more keywords
Th17 lymphocyte‐dependent degradation of joint cartilage by synovial fibroblasts in a humanized mouse model of arthritis and reversal by secukinumab
Sign Up to like & getrecommendations! Published in 2020 at "European Journal of Immunology"
DOI: 10.1002/eji.202048773
Abstract: How T‐helper (Th) lymphocyte subpopulations identified in synovial fluid from patients with juvenile idiopathic arthritis (JIA) (Th17, classic Th1, or nonclassic Th1) drive joint damage is of great interest for the possible use of biological… read more here.
Keywords: degradation; sfbs; th1; model ... See more keywords
Interferon-α regulates abnormally increased expression of RSAD2 in Th17 and Tfh cells in systemic lupus erythematosus patients.
Sign Up to like & getrecommendations! Published in 2023 at "European journal of immunology"
DOI: 10.1002/eji.202350420
Abstract: Systemic lupus erythematosus (SLE) is a chronic autoimmune disease that often involves abnormal activation of regulatory interferon genes and regulation of B cells by CD4+ T cells. RSAD2 is a viral suppressor protein regulated by… read more here.
Keywords: tfh cells; th17; expression; systemic lupus ... See more keywords
Serum brain‐derived neurotrophic factor in coronary heart disease: Correlation with the T helper (Th)1/Th2 ratio, Th17/regulatory T (Treg) ratio, and major adverse cardiovascular events
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Clinical Laboratory Analysis"
DOI: 10.1002/jcla.24803
Abstract: Brain‐derived neurotrophic factor (BDNF) exerts protective roles against dyslipidemia, atherosclerosis, and inflammation in cardiovascular diseases; meanwhile, it retards CD4+ T cell differentiation into T helper (Th)1 and Th17 cells. Hence, this study aimed to investigate… read more here.
Keywords: derived neurotrophic; th2 ratio; brain derived; th17 ... See more keywords
The imbalance of Th17/Treg axis involved in the pathogenesis of preeclampsia
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Cellular Physiology"
DOI: 10.1002/jcp.27315
Abstract: Inappropriate activation of the immune system, particularly the imbalance of T‐helper type 17 (Th17)/regulatory T (Treg) cells is thought to play considerable roles in preeclampsia (PE). To investigate the probable effects of the adaptive immune… read more here.
Keywords: th17 treg; imbalance th17; axis involved; treg axis ... See more keywords
Curcumin regulates the homeostasis of Th17/Treg and improves the composition of gut microbiota in type 2 diabetic mice with colitis
Sign Up to like & getrecommendations! Published in 2022 at "Phytotherapy Research"
DOI: 10.1002/ptr.7404
Abstract: Diabetes mellitus (DM) is one of the most common complications in patients with ulcerative colitis (UC). Curcumin has a wide range of bioactive and pharmacological properties and is commonly used as an adjunct to the… read more here.
Keywords: mice; curcumin; microbiota; colitis curcumin ... See more keywords
Polydatin alleviates DSS‐ and TNBS‐induced colitis by suppressing Th17 cell differentiation via directly inhibiting STAT3
Sign Up to like & getrecommendations! Published in 2022 at "Phytotherapy Research"
DOI: 10.1002/ptr.7533
Abstract: Inflammatory bowel disease (IBD) is a non‐specific chronic intestinal inflammatory disease, often presenting with abdominal pain, diarrhea, bloody stool, anorexia, and body loss. It is difficult to cure completely and a promising treatment is urgently… read more here.
Keywords: stat3; th17; colitis; polydatin ... See more keywords
Murine Th17 cells utilize IL-2 receptor gamma chain cytokines but are resistant to cytokine withdrawal-induced apoptosis
Sign Up to like & getrecommendations! Published in 2017 at "Cancer Immunology, Immunotherapy"
DOI: 10.1007/s00262-017-1965-3
Abstract: Adoptive cellular therapy (ACT) with the Th17 subset of CD4+ T cells can cure established melanoma in preclinical models and holds promise for treating human cancer. However, little is known about the growth factors necessary… read more here.
Keywords: th17 cells; receptor gamma; depletion; th17 ... See more keywords
Controversial Contribution of Th17/IL-17 Toward the Immune Response in Intestinal Fibrosis
Sign Up to like & getrecommendations! Published in 2020 at "Digestive Diseases and Sciences"
DOI: 10.1007/s10620-020-06161-1
Abstract: Intestinal fibrosis is a common outcome of inflammatory bowel diseases (IBDs), becoming clinically apparent in 40% of patients with Crohn’s disease and 5% of those with ulcerative colitis. Effective pharmacological treatments aimed at controlling or… read more here.
Keywords: intestinal fibrosis; fibrosis; contribution; immune response ... See more keywords
Role of the IL-23-T-bet/GATA3 Axis for the Pathogenesis of Ulcerative Colitis.
Sign Up to like & getrecommendations! Published in 2020 at "Inflammation"
DOI: 10.1007/s10753-020-01358-y
Abstract: Ulcerative colitis (UC) has been considered a Th2- and Th17-related disease. However, anti-IL-12/23 p40 antibody, which blocks Th1 and Th17 cell induction and maintenance, has shown efficacy in treating UC, suggesting that UC might not… read more here.
Keywords: th2 th17; expression; ulcerative colitis; bet gata3 ... See more keywords
Th17 cells in renal inflammation and autoimmunity.
Sign Up to like & getrecommendations! Published in 2019 at "Autoimmunity reviews"
DOI: 10.1016/j.autrev.2018.08.006
Abstract: Th17 cells are a distinct lineage of T-cells. These T-cells express IL-17A and the lineage-defining transcription factor RORγt. Th17 cells have a pivotal, physiological role in host defense against pathogens. These pro-inflammatory T-cells are also… read more here.
Keywords: cells renal; th17 cells; renal inflammation; autoimmunity ... See more keywords