Polydatin alleviates DSS‐ and TNBS‐induced colitis by suppressing Th17 cell differentiation via directly inhibiting STAT3
Sign Up to like & getrecommendations! Published in 2022 at "Phytotherapy Research"
DOI: 10.1002/ptr.7533
Abstract: Inflammatory bowel disease (IBD) is a non‐specific chronic intestinal inflammatory disease, often presenting with abdominal pain, diarrhea, bloody stool, anorexia, and body loss. It is difficult to cure completely and a promising treatment is urgently… read more here.
Keywords: stat3; th17; colitis; polydatin ... See more keywords
Autotaxin-Lysophosphatidic Acid Axis Blockade Improves Inflammation by Regulating Th17 Cell Differentiation in DSS-Induced Chronic Colitis Mice
Sign Up to like & getrecommendations! Published in 2019 at "Inflammation"
DOI: 10.1007/s10753-019-01015-z
Abstract: Autotaxin-lysophosphatidic acid (ATX-LPA) axis is closely associated with several inflammation-related diseases. In the colonic mucosa of patients with chronic ulcerative colitis (UC), the expression of ATX and the percentage of Th17 cells are found to… read more here.
Keywords: axis; atx lpa; th17 cell; atx ... See more keywords
Upregulated KAT7 in synovial fibroblasts promotes Th17 cell differentiation and infiltration in rheumatoid arthritis.
Sign Up to like & getrecommendations! Published in 2017 at "Biochemical and biophysical research communications"
DOI: 10.1016/j.bbrc.2017.05.143
Abstract: Rheumatoid arthritis (RA) is a chronic autoimmune disease involving multiple cellular participants, of which synovial fibroblasts (SFs) are tightly connected with the development and progression of RA. Here, we provide evidence confirming that KAT7, an… read more here.
Keywords: cell differentiation; synovial fibroblasts; rheumatoid arthritis; th17 cell ... See more keywords
Lactobacillus acidophilus inhibits bone loss and increases bone heterogeneity in osteoporotic mice via modulating Treg-Th17 cell balance
Sign Up to like & getrecommendations! Published in 2018 at "Bone Reports"
DOI: 10.1016/j.bonr.2018.02.001
Abstract: Osteoporosis is one of the most important but often neglected bone disease associated with aging and postmenopausal condition leading to bone loss and fragility. Probiotics have been associated with various immunomodulatory properties and have the… read more here.
Keywords: treg th17; th17 cell; cell balance; th17 ... See more keywords
Calcium Signaling Controls Pathogenic Th17 Cell-Mediated Inflammation by Regulating Mitochondrial Function.
Sign Up to like & getrecommendations! Published in 2019 at "Cell metabolism"
DOI: 10.1016/j.cmet.2019.01.019
Abstract: Pathogenic Th17 cells play important roles in many autoimmune and inflammatory diseases. Their function depends on T cell receptor (TCR) signaling and cytokines that activate signal transducer and activator of transcription 3 (STAT3). TCR engagement activates… read more here.
Keywords: th17 cell; mitochondrial function; th17; pathogenic th17 ... See more keywords
IL‐33‐matured dendritic cells promote Th17 cell responses via IL‐1&bgr; and IL‐6
Sign Up to like & getrecommendations! Published in 2017 at "Cytokine"
DOI: 10.1016/j.cyto.2017.07.022
Abstract: Graphical abstract Figure. No Caption available. HighlightsIL33 enhances Th17 cell differentiation through DC maturation.IL33 does not directly induce differentiation of naïve CD4+ T cells to Th17 cells.IL33‐matDCs increase surface molecule‐expressions driving T cell activation.IL33‐matDCs promote… read more here.
Keywords: cell responses; bgr; responses via; th17 cell ... See more keywords
Il-23/Th17 cell pathway: A promising target to alleviate thymic inflammation maintenance in myasthenia gravis.
Sign Up to like & getrecommendations! Published in 2019 at "Journal of autoimmunity"
DOI: 10.1016/j.jaut.2018.11.005
Abstract: IL-23/Th17 pathway has been identified to sustain inflammatory condition in several autoimmune diseases and therefore being targeted in various therapeutic and effective approaches. Patients affected with autoimmune myasthenia gravis exhibit a disease effector tissue, the… read more here.
Keywords: th17 cell; cell; myasthenia gravis;
Echinocystic Acid Ameliorates Arthritis in SKG Mice by Suppressing Th17 Cell Differentiation and Human Rheumatoid Arthritis Fibroblast-Like Synoviocytes Inflammation.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of agricultural and food chemistry"
DOI: 10.1021/acs.jafc.2c05802
Abstract: Echinocystic acid (EA), a pentacyclic triterpene, exhibits anti-inflammatory, antioxidant, and analgesic activities to counteract pathological effects in various diseases. Here, we aimed to determine the immunomodulatory effect of EA on zymosan-induced arthritis in SKG mice… read more here.
Keywords: arthritis; skg mice; differentiation; cell differentiation ... See more keywords
Releasing Ski-Smad4 mediated suppression is essential to license Th17 differentiation
Sign Up to like & getrecommendations! Published in 2017 at "Nature"
DOI: 10.1038/nature24283
Abstract: T helper 17 (TH17) cells are critically involved in host defence, inflammation, and autoimmunity. Transforming growth factor β (TGFβ) is instrumental in TH17 cell differentiation by cooperating with interleukin-6 (refs 6, 7). Yet, the mechanism… read more here.
Keywords: cell differentiation; differentiation; th17 cell; ski smad4 ... See more keywords
HIPK2 directs cell type-specific regulation of STAT3 transcriptional activity in Th17 cell differentiation.
Sign Up to like & getrecommendations! Published in 2022 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.1073/pnas.2117112119
Abstract: SignificanceSTAT3 (signal transducer and activator of transcription 3) is a master transcription factor that organizes cellular responses to cytokines and growth factors and is implicated in inflammatory disorders. STAT3 is a well-recognized therapeutic target for… read more here.
Keywords: th17 cell; cell; cell type; type specific ... See more keywords
Triptolide inhibits Th17 differentiation via controlling PKM2-mediated glycolysis in rheumatoid arthritis
Sign Up to like & getrecommendations! Published in 2022 at "Immunopharmacology and Immunotoxicology"
DOI: 10.1080/08923973.2022.2086139
Abstract: Abstract Context Rheumatoid arthritis (RA) is an autoimmune disease with the aberrant differentiation of T helper 17 (Th17) cells. Pyruvate kinase M2 (PKM2), a key enzyme of glycolysis, was associated with Th17 cell differentiation. Aim… read more here.
Keywords: differentiation; cell differentiation; pkm2; th17 cell ... See more keywords