Artemisinin derivative TPN10466 suppresses immune cell migration and Th1/Th17 differentiation to ameliorate disease severity in experimental autoimmune encephalomyelitis.
Sign Up to like & getrecommendations! Published in 2022 at "Cellular immunology"
DOI: 10.1016/j.cellimm.2022.104500
Abstract: Multiple sclerosis (MS) was one of the major conditions causing neurological dysfunction and was an incurable progressive central nervous system disease. Experimental autoimmune encephalomyelitis (EAE) was the most commonly used experimental model of MS. Artemisinin… read more here.
Keywords: eae; tpn10466; th17 differentiation; disease ... See more keywords
Poly I:C primes the suppressive function of human palatine tonsil-derived MSCs against Th17 differentiation by increasing PD-L1 expression.
Sign Up to like & getrecommendations! Published in 2017 at "Immunobiology"
DOI: 10.1016/j.imbio.2016.08.012
Abstract: It has been established that mesenchymal stem cells (MSCs) can have a suppressive effect on T cells, yet much remains unknown about the underlying mechanisms that support this effect. The T cell co-stimulatory pathway involving… read more here.
Keywords: derived mscs; human palatine; th17 differentiation; differentiation ... See more keywords
SKI and SMAD4 are essential for IL-21-induced Th17 differentiation.
Sign Up to like & getrecommendations! Published in 2019 at "Molecular immunology"
DOI: 10.1016/j.molimm.2019.07.029
Abstract: Th17 cells are essential for the pathogenesis of inflammatory and autoimmune diseases. In the presence of TGF-β, the differentiation of Th17 cells can be induced by inflammatory cytokines, especially IL-6, which is mainly produced by… read more here.
Keywords: ski smad4; th17 differentiation; differentiation; induced th17 ... See more keywords
Dendritic cell MST1 inhibits Th17 differentiation
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DOI: 10.1038/ncomms14275
Abstract: Although the differentiation of CD4+T cells is widely studied, the mechanisms of antigen-presenting cell-dependent T-cell modulation are unclear. Here, we investigate the role of dendritic cell (DC)-dependent T-cell differentiation in autoimmune and antifungal inflammation and… read more here.
Keywords: dcs; mst1; th17 differentiation; differentiation ... See more keywords
NP30 stimulates Th17 differentiation through DC in Schistosomiasis Japonicum
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DOI: 10.1111/pim.12528
Abstract: The murine monoclonal anti‐idiotypic antibody, NP30, is a potential vaccine candidate against Schistosoma japonicum. Previous studies have revealed that NP30 has an immunoregulatory effect, but the underlying mechanism for this effect remains unknown. This study… read more here.
Keywords: schistosomiasis; stimulates th17; np30 stimulates; th17 differentiation ... See more keywords
03.22 Vitamin d utilises different pathways to inhibit th17 differentiation dependent on the maturation stage of the cd4+ t cell
Sign Up to like & getrecommendations! Published in 2017 at "Annals of the Rheumatic Diseases"
DOI: 10.1136/annrheumdis-2016-211049.22
Abstract: Background In many human autoimmune diseases, including rheumatoid arthritis (RA), vitamin D is associated with disease suppression. Furthermore, experimental collagen-induced arthritis (CIA) is prevented by 1,25(OH)2D3 supplementation, the active form of vitamin D. Since high… read more here.
Keywords: cd4 cells; effect; th17 differentiation; differentiation ... See more keywords
P2X7 Receptor Expression and Signaling on Dendritic Cells and CD4+ T Cells is Not Required but Can Enhance Th17 Differentiation
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Cell and Developmental Biology"
DOI: 10.3389/fcell.2022.687659
Abstract: The purinergic receptor P2X7 (P2X7R) is important in inflammasome activation and generally considered to favor proinflammatory immune responses. However, there is still a limited understanding of the role of P2X7R signaling in Th cell differentiation,… read more here.
Keywords: cell; p2x7r signaling; cd4 cells; th17 differentiation ... See more keywords
MALT1 regulates Th2 and Th17 differentiation via NF-κB and JNK pathways, as well as correlates with disease activity and treatment outcome in rheumatoid arthritis
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2022.913830
Abstract: Objective MALT1 regulates immunity and inflammation in multiple ways, while its role in rheumatoid arthritis (RA) is obscure. This study aimed to investigate the relationship of MALT1 with disease features, treatment outcome, as well as… read more here.
Keywords: malt1; th17 differentiation; treatment outcome; th2 th17 ... See more keywords
Aloperine Ameliorates IMQ-Induced Psoriasis by Attenuating Th17 Differentiation and Facilitating Their Conversion to Treg
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DOI: 10.3389/fphar.2022.778755
Abstract: Aloperine is an anti-inflammatory compound isolated from the Chinese herb Sophora alopecuroides L. Previously, our group has reported that the generation of induced Treg was promoted by aloperine treatment in a mouse colitis model. However,… read more here.
Keywords: imq induced; th17 differentiation; induced psoriasis; differentiation ... See more keywords
Theophylline Attenuates BLM-Induced Pulmonary Fibrosis by Inhibiting Th17 Differentiation
Sign Up to like & getrecommendations! Published in 2023 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms24021019
Abstract: Idiopathic pulmonary fibrosis (IPF) is a chronic and refractory interstitial lung disease. Although there are two approved drugs for IPF, they were not able to completely cure the disease. Therefore, the development of new drugs… read more here.
Keywords: th17 differentiation; pulmonary fibrosis; blm induced; fibrosis ... See more keywords