Exercise preconditioning attenuates cerebral ischemia-induced neuronal apoptosis, Th17/Treg imbalance, and inflammation in rats by inhibiting the JAK2/STAT3 pathway.
Sign Up to like & getrecommendations! Published in 2023 at "Brain and behavior"
DOI: 10.1002/brb3.3030
Abstract: BACKGROUND Exercise preconditioning (EP) is essential for preventing ischemic stroke. Recent studies have shown that EP exerts neuroprotective effects in the cerebral ischemia-reperfusion injury model. Nonetheless, there have been few reports on the relationship between… read more here.
Keywords: th17 treg; jak2 stat3; group; jak2 ... See more keywords
The imbalance of Th17/Treg axis involved in the pathogenesis of preeclampsia
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Cellular Physiology"
DOI: 10.1002/jcp.27315
Abstract: Inappropriate activation of the immune system, particularly the imbalance of T‐helper type 17 (Th17)/regulatory T (Treg) cells is thought to play considerable roles in preeclampsia (PE). To investigate the probable effects of the adaptive immune… read more here.
Keywords: th17 treg; imbalance th17; axis involved; treg axis ... See more keywords
A high‐calorie diet aggravates LPS‐induced pneumonia by disturbing the gut microbiota and Th17/Treg balance
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Leukocyte Biology"
DOI: 10.1002/jlb.3ma0322-458rr
Abstract: The intestinal flora plays an important role in the inflammatory response to the systemic or local infections in the host. A high‐calorie diet has been shown to aggravate pneumonia and delay recovery, especially in children.… read more here.
Keywords: microbiota; th17 treg; high calorie; lps induced ... See more keywords
Salidroside alleviates ulcerative colitis via inhibiting macrophage pyroptosis and repairing the dysbacteriosis‐associated Th17/Treg imbalance
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DOI: 10.1002/ptr.7636
Abstract: Ulcerative colitis (UC) is a chronic inflammatory bowel disease characterized by flora disequilibrium and mucosal immunity disorder. Here, we report that salidroside effectively restricts experimental colitis from two aspects of intestinal macrophage pyroptosis and dysbacteriosis‐derived… read more here.
Keywords: macrophage pyroptosis; th17 treg; pyroptosis; colitis ... See more keywords
Elevated serum IL-2 and Th17/Treg imbalance are associated with gout
Sign Up to like & getrecommendations! Published in 2024 at "Clinical and Experimental Medicine"
DOI: 10.1007/s10238-023-01253-4
Abstract: Gout is considered an auto-inflammatory disorder, and the immunological drivers have not been fully unraveled. This study compared the peripheral lymphocyte and CD4^+T cell subsets, and cytokines in gout and healthy controls (HCs) to explore… read more here.
Keywords: th17 treg; gout; early onset; onset gout ... See more keywords
Role of Endogenous Melatonin in the Regulation of Th17/Treg Balance during Pregnancy
Sign Up to like & getrecommendations! Published in 2018 at "Bulletin of Experimental Biology and Medicine"
DOI: 10.1007/s10517-018-4013-1
Abstract: We studied the role of endogenous melatonin in the development and functioning of T cells that produce IL-17 (Th17) and regulatory T cells (Treg) during pregnancy. The study was performed ex vivo and in vitro… read more here.
Keywords: th17 treg; pregnancy; role endogenous; melatonin ... See more keywords
XBP1 Knockdown Alleviates Pyroptosis and Promotes Th17/Treg Imbalance in Periodontitis by Inhibiting the IL-17 Signaling Pathway.
Sign Up to like & getrecommendations! Published in 2025 at "Inflammation"
DOI: 10.1007/s10753-025-02316-2
Abstract: Periodontitis is a long-lasting inflammatory condition that significantly affects people's quality of life. This research focused on examining the function and underlying mechanisms of X-box binding protein 1 (XBP1) in the pathogenesis of periodontitis. In… read more here.
Keywords: th17 treg; xbp1 knockdown; signaling pathway; periodontitis ... See more keywords
Anti-CD20 therapy ameliorates β cell function and rebalances Th17/Treg cells in NOD mice
Sign Up to like & getrecommendations! Published in 2022 at "Endocrine"
DOI: 10.1007/s12020-021-02965-x
Abstract: Anti-CD20 therapy delays type 1 diabetes mellitus (T1DM) progression in both nonobese diabetic (NOD) mice and new-onset patients. The mechanism is not completely defined. This study aimed to investigate the effects of anti-CD20 therapy on… read more here.
Keywords: nod mice; anti cd20; cell function; th17 treg ... See more keywords
Altered Th17/Treg ratio as a possible mechanism in pathogenesis of idiopathic membranous nephropathy.
Sign Up to like & getrecommendations! Published in 2021 at "Cytokine"
DOI: 10.1016/j.cyto.2021.155452
Abstract: Idiopathic membranous nephropathy (IMN) as a single organ autoimmune disease is a main cause of nephrotic syndrome in adults which is determined through autoantibodies to podocytes proteins. Th17/regulatory T (Treg) balance has emerged as a… read more here.
Keywords: th17 treg; pathogenesis; altered th17; membranous nephropathy ... See more keywords
Phenotypic and functional profile of Th17 and Treg cells in allergic fungal sinusitis
Sign Up to like & getrecommendations! Published in 2018 at "International Immunopharmacology"
DOI: 10.1016/j.intimp.2018.02.009
Abstract: &NA; Interleukin‐17 producing T helper (Th17) and regulatory T cells (Treg) cells have been identified to play a critical role in atopic inflammation. However, conflicting reports on the role of Th17/Treg cells in allergic fungal… read more here.
Keywords: treg cells; th17 treg; allergic fungal; cells allergic ... See more keywords
The potential therapeutic benefit of resveratrol on Th17/Treg imbalance in immune thrombocytopenic purpura.
Sign Up to like & getrecommendations! Published in 2019 at "International immunopharmacology"
DOI: 10.1016/j.intimp.2019.04.061
Abstract: BACKGROUND Immune thrombocytopenic purpura (ITP) is an autoimmune disease characterized by the restrained production of new platelets and the persistent reduction of existing platelets. An imbalance between Th17 and Treg cells is associated with a… read more here.
Keywords: th17 treg; treg; treg imbalance; resveratrol ... See more keywords