Th2 cells promote eosinophil‐independent pathology in a murine model of allergic bronchopulmonary aspergillosis
Sign Up to like & getrecommendations! Published in 2020 at "European Journal of Immunology"
DOI: 10.1002/eji.201948411
Abstract: Repeated inhalation of airborne conidia derived from the fungus Aspergillus fumigatus (Af) can lead to a severe eosinophil‐dominated inflammatory condition of the lung termed allergic bronchopulmonary aspergillosis (ABPA). ABPA affects about 5 million individuals worldwide… read more here.
Keywords: bronchopulmonary aspergillosis; th2 cells; allergic bronchopulmonary; pathology ... See more keywords
Infiltrated regulatory T cells and Th2 cells in the brain contribute to attenuation of sepsis-associated encephalopathy and alleviation of mental impairments in mice with polymicrobial sepsis
Sign Up to like & getrecommendations! Published in 2021 at "Brain, Behavior, and Immunity"
DOI: 10.1016/j.bbi.2020.11.010
Abstract: Sepsis-associated encephalopathy (SAE) increases not only morbidity and mortality but has been associated with long-lasting mental impairment after hospital discharge in septic patients. Recently, studies have shown that these mental impairments are caused by infection-induced… read more here.
Keywords: sepsis; th2 cells; septic mice; mental impairments ... See more keywords
Recirculating Th2 cells induce severe thymic dysfunction via IL-4/STAT6 signaling pathway.
Sign Up to like & getrecommendations! Published in 2018 at "Biochemical and biophysical research communications"
DOI: 10.1016/j.bbrc.2018.05.030
Abstract: Thymic involution happened early in life, but a certain ratio of activated CD4+ T cells will persistently recirculate into the thymus from the periphery and it have been suggested to be able to inhibit the… read more here.
Keywords: th2 cells; recirculating th2; induce severe; cells induce ... See more keywords
GAB2 regulates type 2 T helper cell differentiation in humans
Sign Up to like & getrecommendations! Published in 2017 at "Cytokine"
DOI: 10.1016/j.cyto.2017.04.027
Abstract: HighlightsIn vivo and in vitro polarized human T helper 2 cells highly expressed GAB2.GAB2 expression was regulated by IL‐4 and STAT6.GAB2 promoted IL‐4 and IL‐13 expression in human Th2 cells. Abstract Th2 cell differentiation involves… read more here.
Keywords: human th2; th2 cells; cell differentiation; gab2 ... See more keywords
Thymic stromal lymphopoietin drives the development of IL-13+ Th2 cells
Sign Up to like & getrecommendations! Published in 2018 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.1073/pnas.1714348115
Abstract: Significance T helper 2 (Th2) cells are defined by their ability to produce the hallmark cytokine IL-4. However, to mediate allergic inflammation in tissues, Th2 cells must secrete additional cytokines including IL-13 and IL-5. We… read more here.
Keywords: th2 cells; cd4 cells; thymic stromal; stromal lymphopoietin ... See more keywords
Interleukin 5-producing ST2+ memory Th2 cells in IgG4-related dacryoadenitis and sialadenitis
Sign Up to like & getrecommendations! Published in 2018 at "Modern Rheumatology"
DOI: 10.1080/14397595.2018.1526357
Abstract: Abstract Objectives: Immunoglobulin (Ig) G4-related disease (IgG4-RD) is often complicated by allergic disorders. This study was conducted to investigate the mechanism of type 2 helper T-inflammation (Th2-inflammation) in IgG4-related dacryoadenitis and sialadenitis (IgG4-DS). Methods: We… read more here.
Keywords: th2 cells; st2 memory; igg4 related; memory th2 ... See more keywords
Targeting glycolysis in Th2 cells by pterostilbene attenuates clinical severities in an asthmatic mouse model and IL‐4 production in peripheral blood from asthmatic patients
Sign Up to like & getrecommendations! Published in 2022 at "Immunology"
DOI: 10.1111/imm.13469
Abstract: Asthma, a major non‐communicable disease, affects both adults and children and is associated with high morbidity compared with other chronic diseases. The glycolysis‐associated activation of type 2 helper T (Th2) cells is the critical immunopathological… read more here.
Keywords: targeting glycolysis; production; peripheral blood; th2 cells ... See more keywords
Toning down the role of eosinophils in eosinophilic oesophagitis
Sign Up to like & getrecommendations! Published in 2023 at "Gut"
DOI: 10.1136/gutjnl-2023-329864
Abstract: Eosinophilic oesophagitis (EoE) is an immunemediated disease of uncertain aetiology. The diagnosis of EoE relies on the epithelial infiltration of eosinophils (peak eosinophil count of ≥15 per highpower field (HPF)) and on the presence of… read more here.
Keywords: toning role; eoe; eosinophilic oesophagitis; role ... See more keywords
lncRNA FR215775 Regulates Th2 Differentiation in Murine Allergic Rhinitis
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Immunology Research"
DOI: 10.1155/2022/7783481
Abstract: To identify the effect of long noncoding RNA (lncRNA) FR215775 in regulating CD4+ T cells on murine models of allergic rhinitis (AR), the expression of lncRNA FR215775 in primary Th2 cells was detected through qRT-PCR.… read more here.
Keywords: lncrna fr215775; th2 cells; allergic rhinitis; fr215775 ... See more keywords
Hematopoietic Prostaglandin D2 Synthase Controls Tfh/Th2 Communication and Limits Tfh Antitumor Effects.
Sign Up to like & getrecommendations! Published in 2022 at "Cancer immunology research"
DOI: 10.1158/2326-6066.cir-21-0568
Abstract: T follicular helper (Tfh) cells are a subset of CD4+ T cells essential in immunity and have a role in helping B cells produce antibodies against pathogens. However, their role during cancer progression remains unknown.… read more here.
Keywords: tfh th2; synthase; tfh cells; hematopoietic prostaglandin ... See more keywords
Microbial antigens-loaded myeloma cells enhance Th2 cell proliferation and myeloma clonogenicity via Th2–myeloma cell interaction
Sign Up to like & getrecommendations! Published in 2019 at "BMC Cancer"
DOI: 10.1186/s12885-019-6469-4
Abstract: Myeloma cells retain B cell functions, considered to be potential antigen presenting cells, yet there is little information regarding promoting Th2 cell proliferation or the direct effects to myeloma on the Th2 cells stimulated by… read more here.
Keywords: th2 cells; myeloma; myeloma cells; cell ... See more keywords