Point mutation L116R in interferon‐regulatory factor 4 differentially impacts key cytokine production in Th2, Th9, and Th17 cells
Sign Up to like & getrecommendations! Published in 2022 at "European Journal of Immunology"
DOI: 10.1002/eji.202249869
Abstract: Upon first activation, CD4+ T cells differentiate into specialized T helper subtypes, dependent on the key transcription factors (TFs) T-bet for Th1, GATA3 for Th2, PU.1 for Th9, and RORγt for Th17. Our group established… read more here.
Keywords: irf4; th17 cells; th9; production ... See more keywords
Staphylococcus aureus‐derived factors promote human Th9 cell polarization and enhance a transcriptional program associated with allergic inflammation
Sign Up to like & getrecommendations! Published in 2022 at "European Journal of Immunology"
DOI: 10.1002/eji.202250083
Abstract: T helper (Th) 9 cells, characterized by robust secretion of IL‐9, have been increasingly associated with allergic diseases. However, whether and how Th9 cells are modulated by environmental stimuli remains poorly understood. In this study,… read more here.
Keywords: associated allergic; th9; staphylococcus aureus; th9 cell ... See more keywords
Isolation and Purification of Th9 Cells for the Study of Inflammatory Diseases in Research and Clinical Settings.
Sign Up to like & getrecommendations! Published in 2017 at "Methods in molecular biology"
DOI: 10.1007/978-1-4939-6877-0_19
Abstract: Th9 cells are associated with atopic and inflammatory diseases, and their increased levels and function correlate with the severity of symptoms in various inflammatory disorders including asthma, food allergy, atopic dermatitis, ulcerative colitis, and psoriatic… read more here.
Keywords: purification th9; th9 cells; isolation purification; inflammatory diseases ... See more keywords
A Method to In Vitro Differentiate Th9 Cells from Mouse Naïve CD4+ T Cells.
Sign Up to like & getrecommendations! Published in 2017 at "Methods in molecular biology"
DOI: 10.1007/978-1-4939-6877-0_4
Abstract: CD4+ T helper cells with the ability to produce effector cytokines provide host protection by regulating immune responses against pathogens. In contrast, these cells are responsible for the development of various inflammatory disease if not… read more here.
Keywords: cd4 cells; th9 cells; differentiate; th9 ... See more keywords
Calcitriol attenuates TLR2/IL-33 signaling pathway to repress Th9 cell differentiation and potentially limits the pathophysiology of rheumatoid arthritis
Sign Up to like & getrecommendations! Published in 2020 at "Molecular and Cellular Biochemistry"
DOI: 10.1007/s11010-020-03914-4
Abstract: There is limited information regarding the TLR2 signaling pathway involved in Th9 cell differentiation. The role of calcitriol in regulating TLR2-mediated Th9 cell development is unknown. Thus, we aimed to unravel the TLR2 signaling pathway… read more here.
Keywords: th9; calcitriol; signaling pathway; th9 cell ... See more keywords
Anaphylatoxins enhance Th9 cell recruitment via the CCL20-CCR6 axis in IgA nephropathy
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Nephrology"
DOI: 10.1007/s40620-020-00708-1
Abstract: Background CD4 + T cells are involved in the pathogenesis of immunoglobulin A nephropathy (IgAN); T helper (Th) 1, Th17 and Th22 cells promote the occurrence and amplification of inflammatory reactions, while regulatory T (Treg)… read more here.
Keywords: th9 cell; c3a c5a; ccl20; th9 ... See more keywords
What’s old is new again: Batf transcription factors and Th9 cells
Sign Up to like & getrecommendations! Published in 2019 at "Mucosal Immunology"
DOI: 10.1038/s41385-019-0155-3
Abstract: Hubble’s law, established by famed astronomer Edwin Hubble, states that the universe is rapidly expanding. Although more figuratively, the same can be said of the rapidly expanding universe of CD4 T cells. In 1986, Mosmann… read more here.
Keywords: transcription; th9 cells; th9; mucosal ... See more keywords
Th9 cells in allergic diseases: A role for the microbiota?
Sign Up to like & getrecommendations! Published in 2019 at "Scandinavian Journal of Immunology"
DOI: 10.1111/sji.12857
Abstract: Since their discovery about 10 years ago, Th9 cells have been increasingly linked to allergic pathologies. Within this review, we summarize the current knowledge on associations between Th9 cells and allergic diseases and acknowledge Th9… read more here.
Keywords: microbiota; allergic diseases; th9 cells; th9 ... See more keywords
A Decade of Th9 Cells: Role of Th9 Cells in Inflammatory Bowel Disease
Sign Up to like & getrecommendations! Published in 2018 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2018.01139
Abstract: T helper cell subsets play a critical role in providing protection against offending pathogens by secreting specific cytokines. However, unrestrained T helper cell responses can promote chronic inflammation-mediated inflammatory diseases. Dysregulated T helper cell responses… read more here.
Keywords: role th9; th9 cells; th9; ibd ... See more keywords