Staphylococcus aureus‐derived factors promote human Th9 cell polarization and enhance a transcriptional program associated with allergic inflammation
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DOI: 10.1002/eji.202250083
Abstract: T helper (Th) 9 cells, characterized by robust secretion of IL‐9, have been increasingly associated with allergic diseases. However, whether and how Th9 cells are modulated by environmental stimuli remains poorly understood. In this study,… read more here.
Keywords: associated allergic; th9; staphylococcus aureus; th9 cell ... See more keywords
Calcitriol attenuates TLR2/IL-33 signaling pathway to repress Th9 cell differentiation and potentially limits the pathophysiology of rheumatoid arthritis
Sign Up to like & getrecommendations! Published in 2020 at "Molecular and Cellular Biochemistry"
DOI: 10.1007/s11010-020-03914-4
Abstract: There is limited information regarding the TLR2 signaling pathway involved in Th9 cell differentiation. The role of calcitriol in regulating TLR2-mediated Th9 cell development is unknown. Thus, we aimed to unravel the TLR2 signaling pathway… read more here.
Keywords: th9; calcitriol; signaling pathway; th9 cell ... See more keywords
Anaphylatoxins enhance Th9 cell recruitment via the CCL20-CCR6 axis in IgA nephropathy
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Nephrology"
DOI: 10.1007/s40620-020-00708-1
Abstract: Background CD4 + T cells are involved in the pathogenesis of immunoglobulin A nephropathy (IgAN); T helper (Th) 1, Th17 and Th22 cells promote the occurrence and amplification of inflammatory reactions, while regulatory T (Treg)… read more here.
Keywords: th9 cell; c3a c5a; ccl20; th9 ... See more keywords
Fas signaling-mediated TH9 cell differentiation favors bowel inflammation and antitumor functions
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DOI: 10.1038/s41467-019-10889-4
Abstract: Fas induces apoptosis in activated T cell to maintain immune homeostasis, but the effects of non-apoptotic Fas signaling on T cells remain unclear. Here we show that Fas promotes TH9 cell differentiation by activating NF-κB… read more here.
Keywords: cell; fas; cell differentiation; th9 cell ... See more keywords
Th9 cells in allergic diseases: A role for the microbiota?
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DOI: 10.1111/sji.12857
Abstract: Since their discovery about 10 years ago, Th9 cells have been increasingly linked to allergic pathologies. Within this review, we summarize the current knowledge on associations between Th9 cells and allergic diseases and acknowledge Th9… read more here.
Keywords: microbiota; allergic diseases; th9 cells; th9 ... See more keywords
Th9 Cell Differentiation and Its Dual Effects in Tumor Development
Sign Up to like & getrecommendations! Published in 2020 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2020.01026
Abstract: With the improved understanding of the molecular pathogenesis and characteristics of cancers, the critical role of the immune system in preventing tumor development has been widely accepted. The understanding of the relationship between the immune… read more here.
Keywords: cell differentiation; differentiation dual; th9 cell; tumor development ... See more keywords