Microparticles from β-thalassaemia/HbE patients induce endothelial cell dysfunction
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DOI: 10.1038/s41598-018-31386-6
Abstract: Thromboembolic complication occurs frequently in β-thalassaemia/HbE patients, particularly in splenectomised patients. Endothelial cells play an important role in thrombosis. There is strong evidence of endothelial cell activation and dysfunction in β-thalassaemia. Microparticles (MPs) are associated… read more here.
Keywords: cell dysfunction; hbe patients; endothelial cell; cell ... See more keywords
A comprehensive study of immune function and immunophenotyping of white blood cells from β‐thalassaemia/HbE patients on hydroxyurea supports the safety of the drug
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DOI: 10.1111/bjh.18508
Abstract: Hydroxyurea (HU) (hydroxycarbamide) is used as a therapeutic option in β‐thalassaemia to increase fetal haemoglobin, which results in a reduced requirement for blood transfusion. However, a potential serious adverse effect of HU is neutropenia. Abnormal… read more here.
Keywords: hbe patients; blood; thalassaemia hbe; study ... See more keywords