Curcuminoids supplementation ameliorates iron overload, oxidative stress, hypercoagulability, and inflammation in non-transfusion-dependent β-thalassemia/Hb E patients
Sign Up to like & getrecommendations! Published in 2021 at "Annals of Hematology"
DOI: 10.1007/s00277-020-04379-7
Abstract: Curcuminoids, polyphenol compounds in turmeric, possess several pharmacological properties including antioxidant, iron-chelating, and anti-inflammatory activities. Effects of curcuminoids in thalassemia patients have been explored in a limited number of studies using different doses of curcuminoids.… read more here.
Keywords: thalassemia patients; stress; stress hypercoagulability; oxidative stress ... See more keywords
Hydroxyurea Treated β-Thalassemia Children Demonstrate a Shift in Metabolism Towards Healthy Pattern
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DOI: 10.1038/s41598-018-33540-6
Abstract: Augmentation of fetal hemoglobin (HbF) production has been an enduring therapeutic objective in β-thalassemia patients for which hydroxyurea (HU) has largely been the drug of choice and the most cost-effective approach. A serum metabolomics study… read more here.
Keywords: metabolism towards; treated patients; towards healthy; thalassemia patients ... See more keywords
Correlation of hepcidin and serum ferritin levels in thalassemia patients at Chiang Mai University Hospital
Sign Up to like & getrecommendations! Published in 2021 at "Bioscience Reports"
DOI: 10.1042/bsr20203352
Abstract: Abstract Hepcidin is a key iron-regulatory hormone, the production of which is controlled by iron stores, inflammation, hypoxia and erythropoiesis. The regulation of iron by hepcidin is of clinical importance in thalassemia patients in which… read more here.
Keywords: thalassemia patients; hepcidin; ferritin; serum hepcidin ... See more keywords
Genotype-Phenotype Study of β-Thalassemia Patients in Sabah
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DOI: 10.1080/03630269.2023.2169154
Abstract: Abstract β-thalassemia is a serious public health problem in Sabah due to its high prevalence. This study aimed to investigate the effects of different types of β-globin gene mutations, coinheritance with α-globin gene mutations, XmnI-Gγ,… read more here.
Keywords: gene mutations; thalassemia patients; thalassemia; globin gene ... See more keywords
Assessment of cystatin C in pediatric sickle cell disease and β-thalassemia as a marker of subclinical cardiovascular dysfunction: a case-control study
Sign Up to like & getrecommendations! Published in 2021 at "Pediatric Hematology and Oncology"
DOI: 10.1080/08880018.2021.1894280
Abstract: Abstract Cardiovascular complications represent the main determinant of survival in patients with hemoglobinopathies. Serum cystatin C is a well-known marker of nephropathy in sickle cell disease (SCD) and β-thalassemia patients that has recently emerged as… read more here.
Keywords: cardiovascular dysfunction; thalassemia; scd thalassemia; cystatin ... See more keywords
Diagnosis and treatment of cardiac iron overload in transfusion-dependent thalassemia patients
Sign Up to like & getrecommendations! Published in 2018 at "Expert Review of Hematology"
DOI: 10.1080/17474086.2018.1476134
Abstract: ABSTRACT Introduction: Thalassemia is among the most common genetic diseases. Patients with severe forms of the disease are transfusion-dependent, leading to iron overload. A condition which can eventually develop in the iron-loaded heart is iron… read more here.
Keywords: transfusion dependent; iron overload; thalassemia patients; iron ... See more keywords
Hepatitis C Virus (HCV) Transmitted Transfusion Risk Among β-Thalassemia Patients in Egypt
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DOI: 10.1093/ajcp/aqz121.008
Abstract: Introduction: β-Thalassemia is an inherited abnormal condition that results in hemolytic anemia. It is the most common monogenic disorder in the world. The Mediterranean countries have the highest prevalence of β-thalassemia (2%-18%), and in Egypt,… read more here.
Keywords: risk; hcv; transfusion; hcv transmitted ... See more keywords
Are people getting quality thalassemia care in twin cities of Pakistan? A comparison with international standards
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DOI: 10.1093/intqhc/mzx198
Abstract: Objectives: This study was conducted to determine if thalassemia patients were getting quality care in Rawalpindi and Islamabad, Pakistan, as per international standards and to identify determinants for better quality of thalassemia care. Design: A… read more here.
Keywords: quality; international standards; thalassemia patients; care ... See more keywords
Fertility and pregnancy in Iranian thalassemia patients: An update on transfusion complications
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DOI: 10.1111/tme.12707
Abstract: Despite the significant advances in thalassemia pathobiology and efficacy of chelation regimens, complications of transfusion therapy have attenuated the reproductive health of thalassemia patients. Depending on clinical profiles, we aimed to assess the fertility status… read more here.
Keywords: transfusion; pregnancy iranian; fertility pregnancy; thalassemia patients ... See more keywords
A Smart Chatbot for Interactive Management in Beta Thalassemia Patients
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DOI: 10.1155/2022/9734518
Abstract: Background β-thalassemia is an inherited blood disorder that affects the production of hemoglobin molecules owing to the reduction or absence of beta chains. Transfusion therapy has had a key role in extending the lifespan of… read more here.
Keywords: information; system; beta; thalassemia patients ... See more keywords
Cardiorenal syndrome in thalassemia patients
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DOI: 10.1186/s12882-020-01990-8
Abstract: Background Cardiorenal syndrome (CRS), a serious condition with high morbidity and mortality, is characterized by the coexistence of cardiac abnormality and renal dysfunction. There is limited information about CRS in association thalassemia. This study aimed… read more here.
Keywords: crs; thalassemia; association; cardiorenal syndrome ... See more keywords