Efficacité et tolérance du thalidomide dans le lupus érythémateux cutané : revue systématique et méta-analyse
Sign Up to like & getrecommendations! Published in 2017 at "Annales De Dermatologie Et De Venereologie"
DOI: 10.1016/j.annder.2017.09.494
Abstract: Introduction Le thalidomide a montre d’excellents resultats dans le lupus erythemateux cutane (LEC) en cas d’echec des antipaludeens de synthese. Neanmoins, la prescription est limitee par la survenue d’effets indesirables potentiellement graves comme les neuropathies… read more here.
Keywords: reponse; revue; tolerance; prevalence ... See more keywords
Thalidomide reduces glycerol-induced acute kidney injury by inhibition of NF-κB, NLRP3 inflammasome, COX-2 and inflammatory cytokines.
Sign Up to like & getrecommendations! Published in 2021 at "Cytokine"
DOI: 10.1016/j.cyto.2021.155574
Abstract: Acute kidney injury (AKI) is an important clinical complication of rhabdomyolysis. The inflammatory processes are involved in the pathogenesis of AKI induced by rhabdomyolysis. Thalidomide is an anti-inflammatory agent that has been used in the… read more here.
Keywords: kidney injury; glycerol; inflammatory; acute kidney ... See more keywords
Comparative analysis of the use and control of thalidomide in Brazil and different countries: is it possible to say there is safety?
Sign Up to like & getrecommendations! Published in 2021 at "Expert opinion on drug safety"
DOI: 10.1080/14740338.2021.1953467
Abstract: INTRODUCTION One of the biggest drug disasters in history has not prevented thalidomide from being used to treat various clinical conditions. Currently, Brazil has a worrying scenario: high consumption of the drug and, cases of… read more here.
Keywords: use; analysis; safety; drug ... See more keywords
P25 Thalidomide administration through a nasogastric tube
Sign Up to like & getrecommendations! Published in 2018 at "Archives of Disease in Childhood"
DOI: 10.1136/archdischild-2017-314584.36
Abstract: Introduction LA, 15 year old female diagnosed with tuberculosis meningitis (TBM). General paediatric team recommended, in combination with existing adjunctive therapy, initiation of Thalidomide, a non-formulary drug. Challenge Administration of medication, for LA, was via a… read more here.
Keywords: team; administration; nasogastric tube; pharmacy ... See more keywords
Thalidomide Attenuates Skin Lesions and Inflammation in Rosacea-Like Mice Induced by Long-Term Exposure of LL-37
Sign Up to like & getrecommendations! Published in 2022 at "Drug Design, Development and Therapy"
DOI: 10.2147/dddt.s393122
Abstract: Purpose Most of the existing studies focus on the early inflammation of rosacea, with few interventions on the later development of fibrosis and the relationship between thalidomide and rosacea. The purpose of this study was… read more here.
Keywords: long term; inflammation rosacea; group; fibrosis ... See more keywords
A Phase Ib Study of the Simmitecan Single Agent and in Combination With 5-Fluorouracil/Leucovorin or Thalidomide in Patients With Advanced Solid Tumor
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Pharmacology"
DOI: 10.3389/fphar.2022.833583
Abstract: Background: Simmitecan is a potent inhibitor of topoisomerase I with anti-tumor activity. This phase Ib trial was conducted to investigate the safety and anti-tumor effect of simmitecan alone or in combination with other drugs. Methods:… read more here.
Keywords: simmitecan thalidomide; patients advanced; combination; tumor ... See more keywords
Exosome-Modified Liposomes Targeted Delivery of Thalidomide to Regulate Treg Cells for Antitumor Immunotherapy
Sign Up to like & getrecommendations! Published in 2023 at "Pharmaceutics"
DOI: 10.3390/pharmaceutics15041074
Abstract: Thalidomide (THD), a synthetic derivative of glutamic acid, was initially used as a sedative and antiemetic until the 1960s, when it was found to cause devastating teratogenic effects. However, subsequent studies have clearly demonstrated the… read more here.
Keywords: liposomes targeted; targeted delivery; modified liposomes; exosome modified ... See more keywords