Design, synthesis, anticancer evaluation, and in silico ADMET analysis of novel thalidomide analogs as promising immunomodulatory agents
Sign Up to like & getrecommendations! Published in 2023 at "RSC Advances"
DOI: 10.1039/d3ra00066d
Abstract: Immunomodulatory medications like thalidomide and its analogs prevent the production of some proinflammatory cytokines linked to cancer. A new series of thalidomide analogs were designed and synthesized in order to develop potential antitumor immunomodulatory agents.… read more here.
Keywords: design synthesis; synthesis anticancer; immunomodulatory agents; silico admet ... See more keywords
Antiangiogenic Activity and in Silico Cereblon Binding Analysis of Novel Thalidomide Analogs
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DOI: 10.3390/molecules25235683
Abstract: Due to its antiangiogenic and anti-immunomodulatory activity, thalidomide continues to be of clinical interest despite its teratogenic actions, and efforts to synthesize safer, clinically active thalidomide analogs are continually underway. In this study, a cohort… read more here.
Keywords: antiangiogenic activity; cereblon binding; cereblon; thalidomide analogs ... See more keywords