Discovery of CRBN as a target of thalidomide: a breakthrough for progress in the development of protein degraders.
Sign Up to like & getrecommendations! Published in 2022 at "Chemical Society reviews"
DOI: 10.1039/d2cs00116k
Abstract: Progress in strategies aimed at breaking down therapeutic target proteins has led to a paradigm shift in drug discovery. Thalidomide and its derivatives are the only protein degraders currently used in clinical practice. Our understanding… read more here.
Keywords: thalidomide derivatives; crbn; progress; protein degraders ... See more keywords