THBS1 facilitates colorectal liver metastasis through enhancing epithelial–mesenchymal transition
Sign Up to like & getrecommendations! Published in 2020 at "Clinical and Translational Oncology"
DOI: 10.1007/s12094-020-02308-8
Abstract: Objective Liver metastasis is one of the major causes of cancer-related death in patients with colorectal cancer (CRC). The purpose of this study was to identify specific molecules which are involved in colorectal liver metastasis… read more here.
Keywords: colorectal liver; metastasis; thbs1; epithelial mesenchymal ... See more keywords
Thrombospondin 1 improves hepatic steatosis in diet-induced insulin-resistant mice and is associated with hepatic fat content in humans
Sign Up to like & getrecommendations! Published in 2020 at "EBioMedicine"
DOI: 10.1016/j.ebiom.2020.102849
Abstract: Background Nonalcoholic fatty liver disease (NAFLD) is associated with altered production of secreted proteins. Increased understanding of secreted proteins could lead to improved prediction and treatment of NAFLD. Here, we aimed to discover novel secreted… read more here.
Keywords: hepatic steatosis; hepatic fat; thbs1; mice ... See more keywords
Thrombospondin-1 Mediates Axon Regeneration in Retinal Ganglion Cells
Sign Up to like & getrecommendations! Published in 2019 at "Neuron"
DOI: 10.1016/j.neuron.2019.05.044
Abstract: Neuronal subtypes show diverse injury responses, but the molecular underpinnings remain elusive. Using transgenic mice that allow reliable visualization of axonal fate, we demonstrate that intrinsically photosensitive retinal ganglion cells (ipRGCs) are both resilient to… read more here.
Keywords: axon regeneration; retinal ganglion; regeneration; ganglion cells ... See more keywords
O-fucosylation of thrombospondin type I repeats is dispensable for trafficking thrombospondin 1 to platelet secretory granules.
Sign Up to like & getrecommendations! Published in 2023 at "Glycobiology"
DOI: 10.1093/glycob/cwad006
Abstract: Thrombospondin 1 (THBS1) is a secreted extracellular matrix glycoprotein that regulates a variety of cellular and physiological processes. THBS1's diverse functions are attributed to interactions between the modular domains of THBS1 with an array of… read more here.
Keywords: pofut2; type repeats; thbs1; secretory granules ... See more keywords
Circulating THBS1: A Risk Factor for Nonalcoholic Fatty Liver Disease in Obese Children
Sign Up to like & getrecommendations! Published in 2022 at "Annals of Nutrition and Metabolism"
DOI: 10.1159/000527780
Abstract: Introduction: Thrombospondin 1 (THBS1) is a highly expressed adipokine in adults with obesity. In the present study, we aimed to investigate the clinical significance of THBS1in children with obesity and nonalcoholic fatty liver disease (NAFLD)… read more here.
Keywords: nonalcoholic fatty; fatty liver; liver disease; obese children ... See more keywords
Role of Thrombospondin-1 in Mechanotransduction and Development of Thoracic Aortic Aneurysm in Mouse and Humans
Sign Up to like & getrecommendations! Published in 2018 at "Circulation Research"
DOI: 10.1161/circresaha.118.313105
Abstract: Rationale: Abnormal mechanosensing of smooth muscle cells (SMCs) resulting from the defective elastin-contractile units has been suggested to drive the formation of thoracic aortic aneurysms; however, the precise molecular mechanism has not been elucidated. Objective:… read more here.
Keywords: aortic aneurysms; formation; thoracic aortic; thbs1 ... See more keywords
Genetic regulation of THBS1 methylation in diabetic retinopathy
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Endocrinology"
DOI: 10.3389/fendo.2022.991803
Abstract: Background Diabetic retinopathy (DR) is a common and serious microvascular complication of diabetes mellitus (DM), but its pathological mechanism, especially the formation mechanism of new blood vessels remains unclear. Thrombospondin-1 (THBS1) is a potent endogenous… read more here.
Keywords: methylation; meqtls; thbs1; value ... See more keywords
Intraperitoneally Delivered Mesenchymal Stem Cells Alleviate Experimental Colitis Through THBS1-Mediated Induction of IL-10-Competent Regulatory B Cells
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2022.853894
Abstract: Mesenchymal stem cells (MSCs) show promising therapeutic potential in treating inflammatory bowel disease (IBD), and intraperitoneal delivery of MSCs have become a more effective route for IBD treatment. However, the underlying mechanisms are still poorly… read more here.
Keywords: intraperitoneally delivered; thbs1; colitis; mesenchymal stem ... See more keywords
Yth m6A RNA-Binding Protein 1 Regulates Osteogenesis of MC3T3-E1 Cells under Hypoxia via Translational Control of Thrombospondin-1
Sign Up to like & getrecommendations! Published in 2023 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms24021741
Abstract: Peri-implantitis is a major factor affecting implant prognosis, and the specific anatomy of the peri-implant area makes it more vulnerable to the local hypoxic environment caused by inflammation. N6-methyladenosine (m6A) plays a vital role in… read more here.
Keywords: yth m6a; osteogenic differentiation; ythdf1; thbs1 ... See more keywords