THBS1 facilitates colorectal liver metastasis through enhancing epithelial–mesenchymal transition
Sign Up to like & getrecommendations! Published in 2020 at "Clinical and Translational Oncology"
DOI: 10.1007/s12094-020-02308-8
Abstract: Objective Liver metastasis is one of the major causes of cancer-related death in patients with colorectal cancer (CRC). The purpose of this study was to identify specific molecules which are involved in colorectal liver metastasis… read more here.
Keywords: colorectal liver; metastasis; thbs1; epithelial mesenchymal ... See more keywords
Thrombospondin 1 improves hepatic steatosis in diet-induced insulin-resistant mice and is associated with hepatic fat content in humans
Sign Up to like & getrecommendations! Published in 2020 at "EBioMedicine"
DOI: 10.1016/j.ebiom.2020.102849
Abstract: Background Nonalcoholic fatty liver disease (NAFLD) is associated with altered production of secreted proteins. Increased understanding of secreted proteins could lead to improved prediction and treatment of NAFLD. Here, we aimed to discover novel secreted… read more here.
Keywords: hepatic steatosis; hepatic fat; thbs1; mice ... See more keywords
Thrombospondin-1 Mediates Axon Regeneration in Retinal Ganglion Cells
Sign Up to like & getrecommendations! Published in 2019 at "Neuron"
DOI: 10.1016/j.neuron.2019.05.044
Abstract: Neuronal subtypes show diverse injury responses, but the molecular underpinnings remain elusive. Using transgenic mice that allow reliable visualization of axonal fate, we demonstrate that intrinsically photosensitive retinal ganglion cells (ipRGCs) are both resilient to… read more here.
Keywords: axon regeneration; retinal ganglion; regeneration; ganglion cells ... See more keywords
THBS1 regulates decidualization in URSA.
Sign Up to like & getrecommendations! Published in 2024 at "Biology of reproduction"
DOI: 10.1093/biolre/ioae079
Abstract: Inappropriate endometrial stromal decidualization has been implied as an important reason of many pregnancy-related complications, such as unexplained recurrent spontaneous abortion (URSA), preeclampsia and intrauterine growth restriction. Here, we observed that thrombospondin-1 (THBS1), an adhesive… read more here.
Keywords: thbs1 regulates; regulates decidualization; decidualization; thbs1 ... See more keywords
Cell-dependent contributions of thrombospondin-1 to the rupture of abdominal aortic aneurysm in mice.
Sign Up to like & getrecommendations! Published in 2025 at "Cardiovascular research"
DOI: 10.1093/cvr/cvaf243
Abstract: AIMS Abdominal aortic aneurysms (AAA) rupture is a life-threatening event with unclear molecular mechanisms. Our previous work demonstrated elevated levels of the matricellular protein thrombospondin-1 (TSP1, encoded by Thbs1) in human and mouse AAA tissues.… read more here.
Keywords: mice; thbs1; abdominal aortic; cell ... See more keywords
O-fucosylation of thrombospondin type I repeats is dispensable for trafficking thrombospondin 1 to platelet secretory granules.
Sign Up to like & getrecommendations! Published in 2023 at "Glycobiology"
DOI: 10.1093/glycob/cwad006
Abstract: Thrombospondin 1 (THBS1) is a secreted extracellular matrix glycoprotein that regulates a variety of cellular and physiological processes. THBS1's diverse functions are attributed to interactions between the modular domains of THBS1 with an array of… read more here.
Keywords: pofut2; type repeats; thbs1; secretory granules ... See more keywords
Circulating THBS1: A Risk Factor for Nonalcoholic Fatty Liver Disease in Obese Children
Sign Up to like & getrecommendations! Published in 2022 at "Annals of Nutrition and Metabolism"
DOI: 10.1159/000527780
Abstract: Introduction: Thrombospondin 1 (THBS1) is a highly expressed adipokine in adults with obesity. In the present study, we aimed to investigate the clinical significance of THBS1in children with obesity and nonalcoholic fatty liver disease (NAFLD)… read more here.
Keywords: nonalcoholic fatty; fatty liver; liver disease; obese children ... See more keywords
Role of Thrombospondin-1 in Mechanotransduction and Development of Thoracic Aortic Aneurysm in Mouse and Humans
Sign Up to like & getrecommendations! Published in 2018 at "Circulation Research"
DOI: 10.1161/circresaha.118.313105
Abstract: Rationale: Abnormal mechanosensing of smooth muscle cells (SMCs) resulting from the defective elastin-contractile units has been suggested to drive the formation of thoracic aortic aneurysms; however, the precise molecular mechanism has not been elucidated. Objective:… read more here.
Keywords: aortic aneurysms; formation; thoracic aortic; thbs1 ... See more keywords
Endothelial cell-derived thrombospondin-1 negatively affects hematopoietic function during aging
Sign Up to like & getrecommendations! Published in 2025 at "Blood"
DOI: 10.1182/blood-2025-429
Abstract: The pool of candidates for treatment of hematological malignancies via bone marrow (BM) transplants has greatly expanded due to advancements in conditioning strategies, but these carry an increased risk of failure and complication as patients… read more here.
Keywords: cell specific; treatment; thbs1; recovery ... See more keywords
Genetic regulation of THBS1 methylation in diabetic retinopathy
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Endocrinology"
DOI: 10.3389/fendo.2022.991803
Abstract: Background Diabetic retinopathy (DR) is a common and serious microvascular complication of diabetes mellitus (DM), but its pathological mechanism, especially the formation mechanism of new blood vessels remains unclear. Thrombospondin-1 (THBS1) is a potent endogenous… read more here.
Keywords: methylation; meqtls; thbs1; value ... See more keywords
Intraperitoneally Delivered Mesenchymal Stem Cells Alleviate Experimental Colitis Through THBS1-Mediated Induction of IL-10-Competent Regulatory B Cells
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2022.853894
Abstract: Mesenchymal stem cells (MSCs) show promising therapeutic potential in treating inflammatory bowel disease (IBD), and intraperitoneal delivery of MSCs have become a more effective route for IBD treatment. However, the underlying mechanisms are still poorly… read more here.
Keywords: intraperitoneally delivered; thbs1; colitis; mesenchymal stem ... See more keywords