Circ‐OPHN1 suppresses the proliferation, migration, and invasion of trophoblast cells through mediating miR‐558/THBS2 axis
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DOI: 10.1002/ddr.21931
Abstract: Preeclampsia (PE) is one of the most serious diseases during pregnancy. Circular RNAs (circRNAs) are strongly related to the occurrence of preeclampsia. Herein, we aimed to explore the potential role and mechanism of circRNA oligophrenin… read more here.
Keywords: thbs2; mir 558; circ ophn1; circ ... See more keywords
Silencing of COL1A2, COL6A3, and THBS2 inhibits gastric cancer cell proliferation, migration, and invasion while promoting apoptosis through the PI3k‐Akt signaling pathway
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DOI: 10.1002/jcb.26524
Abstract: This study explores the effect of COL1A2, COL6A3, and THBS2 gene silencing on proliferation, migration, invasion, and apoptosis of gastric cancer cells through the PI3K‐Akt signaling pathway. The gastric cancer microarray expression data (GSE19826, GSE79973,… read more here.
Keywords: gastric cancer; thbs2; col1a2 col6a3; col6a3 thbs2 ... See more keywords
Circulating Thrombospondin-2 enhances prediction of malignant intraductal papillary mucinous neoplasm.
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DOI: 10.1016/j.amjsurg.2018.08.026
Abstract: BACKGROUND IPMNs are cystic pancreatic lesions with variable malignant potential. Thrombospondin-2 (THBS2)-an endogenous, anti-angiogenic matrix glycoprotein-may modulate tumor progression. We hypothesized that circulating levels of THBS2 could aid in preoperative prediction of malignant IPMN. METHODS… read more here.
Keywords: high grade; grade; prediction malignant; ipmn ... See more keywords
Overexpressed Thrombospondin 2 Induced Osteogenic Differentiation of Valve Interstitial Cells via Inhibition of Akt/NF-κB Signaling Pathway to Promote Calcific Aortic Valve Disease Development
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DOI: 10.1155/2022/2022958
Abstract: Thrombospondin 2 (THBS2) is reported to participate in the development of calcific aortic valve disease (CAVD), while the effects are not elucidated completely. The study aimed to explore the role and mechanism of THBS2 in… read more here.
Keywords: thbs2; development; valve; osteogenic differentiation ... See more keywords
Thrombospondin 2 is a Functional Predictive and Prognostic Biomarker for Triple-Negative Breast Cancer Patients With Neoadjuvant Chemotherapy
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DOI: 10.3389/pore.2022.1610559
Abstract: Background: Triple-negative breast cancer (TNBC) is characterized by a more aggressive biological behavior and unfavorable outcome. Circulating and histological expression of THBS2 has been demonstrated to be a novel diagnostic and prognostic biomarker in patients… read more here.
Keywords: breast cancer; negative breast; triple negative; thbs2 ... See more keywords
Multi-scale integrative analyses identify THBS2+ cancer-associated fibroblasts as a key orchestrator promoting aggressiveness in early-stage lung adenocarcinoma
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DOI: 10.7150/thno.69590
Abstract: Rationale: Subsets of patients with early-stage lung adenocarcinoma (LUAD) have a poor post-surgical course after curative surgery. However, biomarkers stratifying this high-risk subset and molecular underpinnings underlying the aggressive phenotype remain unclear. Methods: We integrated… read more here.
Keywords: early stage; thbs2; stage luad; stage ... See more keywords