Circ‐OPHN1 suppresses the proliferation, migration, and invasion of trophoblast cells through mediating miR‐558/THBS2 axis
Sign Up to like & getrecommendations! Published in 2022 at "Drug Development Research"
DOI: 10.1002/ddr.21931
Abstract: Preeclampsia (PE) is one of the most serious diseases during pregnancy. Circular RNAs (circRNAs) are strongly related to the occurrence of preeclampsia. Herein, we aimed to explore the potential role and mechanism of circRNA oligophrenin… read more here.
Keywords: thbs2; mir 558; circ ophn1; circ ... See more keywords
Silencing of COL1A2, COL6A3, and THBS2 inhibits gastric cancer cell proliferation, migration, and invasion while promoting apoptosis through the PI3k‐Akt signaling pathway
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Cellular Biochemistry"
DOI: 10.1002/jcb.26524
Abstract: This study explores the effect of COL1A2, COL6A3, and THBS2 gene silencing on proliferation, migration, invasion, and apoptosis of gastric cancer cells through the PI3K‐Akt signaling pathway. The gastric cancer microarray expression data (GSE19826, GSE79973,… read more here.
Keywords: gastric cancer; thbs2; col1a2 col6a3; col6a3 thbs2 ... See more keywords
Circulating Thrombospondin-2 enhances prediction of malignant intraductal papillary mucinous neoplasm.
Sign Up to like & getrecommendations! Published in 2019 at "American journal of surgery"
DOI: 10.1016/j.amjsurg.2018.08.026
Abstract: BACKGROUND IPMNs are cystic pancreatic lesions with variable malignant potential. Thrombospondin-2 (THBS2)-an endogenous, anti-angiogenic matrix glycoprotein-may modulate tumor progression. We hypothesized that circulating levels of THBS2 could aid in preoperative prediction of malignant IPMN. METHODS… read more here.
Keywords: high grade; grade; prediction malignant; ipmn ... See more keywords
P-648 The Role of THBS2 in Ovarian Function and Its Potential Mechanism in Primary Ovarian Insufficiency
Sign Up to like & getrecommendations! Published in 2025 at "Human Reproduction"
DOI: 10.1093/humrep/deaf097.954
Abstract: What is the role of THBS2 in ovarian function, and what is its potential mechanism in primary ovarian insufficiency (POI)? THBS2 knockout mice demonstrate decreased fertility and ovarian dysfunction, accompanied by the downregulation of FMOD,… read more here.
Keywords: thbs2; role thbs2; ovarian function; thbs2 ovarian ... See more keywords
Overexpressed Thrombospondin 2 Induced Osteogenic Differentiation of Valve Interstitial Cells via Inhibition of Akt/NF-κB Signaling Pathway to Promote Calcific Aortic Valve Disease Development
Sign Up to like & getrecommendations! Published in 2022 at "Disease Markers"
DOI: 10.1155/2022/2022958
Abstract: Thrombospondin 2 (THBS2) is reported to participate in the development of calcific aortic valve disease (CAVD), while the effects are not elucidated completely. The study aimed to explore the role and mechanism of THBS2 in… read more here.
Keywords: thbs2; development; valve; osteogenic differentiation ... See more keywords
Abstract 2497: Extracellular vesicle based ALPPL2 and THBS2 as biomarkers for disease monitoring in patients with pancreatic ductal adenocarcinoma
Sign Up to like & getrecommendations! Published in 2024 at "Cancer Research"
DOI: 10.1158/1538-7445.am2024-2497
Abstract: Pancreatic ductal adenocarcinoma (PDAC) remains a formidable challenge in the realm of oncology, characterized by its aggressive nature and resistance to treatment. Several therapeutic regimens have been shown to extend patient survival, but the majority… read more here.
Keywords: alppl2 thbs2; disease monitoring; thbs2 evs; monitoring patients ... See more keywords
THBS2 + cancer-associated fibroblasts promote EMT leading to oxaliplatin resistance via COL8A1-mediated PI3K/AKT activation in colorectal cancer
Sign Up to like & getrecommendations! Published in 2024 at "Molecular Cancer"
DOI: 10.1186/s12943-024-02180-y
Abstract: Cancer-associated fibroblasts (CAFs) exert multiple tumor-promoting functions and are key contributors to drug resistance. The mechanisms by which specific subsets of CAFs facilitate oxaliplatin resistance in colorectal cancer (CRC) have not been fully explored. This… read more here.
Keywords: cancer; resistance; crc; oxaliplatin resistance ... See more keywords
Thrombospondin 2 is a Functional Predictive and Prognostic Biomarker for Triple-Negative Breast Cancer Patients With Neoadjuvant Chemotherapy
Sign Up to like & getrecommendations! Published in 2022 at "Pathology and Oncology Research"
DOI: 10.3389/pore.2022.1610559
Abstract: Background: Triple-negative breast cancer (TNBC) is characterized by a more aggressive biological behavior and unfavorable outcome. Circulating and histological expression of THBS2 has been demonstrated to be a novel diagnostic and prognostic biomarker in patients… read more here.
Keywords: breast cancer; negative breast; triple negative; thbs2 ... See more keywords
Multi-scale integrative analyses identify THBS2+ cancer-associated fibroblasts as a key orchestrator promoting aggressiveness in early-stage lung adenocarcinoma
Sign Up to like & getrecommendations! Published in 2022 at "Theranostics"
DOI: 10.7150/thno.69590
Abstract: Rationale: Subsets of patients with early-stage lung adenocarcinoma (LUAD) have a poor post-surgical course after curative surgery. However, biomarkers stratifying this high-risk subset and molecular underpinnings underlying the aggressive phenotype remain unclear. Methods: We integrated… read more here.
Keywords: early stage; thbs2; stage luad; stage ... See more keywords