Structure-Based Discovery of Novel Glycinergic Modulators
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DOI: 10.1016/j.bpj.2016.11.2998
Abstract: Marijuana's analgesic effects can be attributed to the allosteric modulation of glycine receptors (GlyRs) by Δ9-tetrahydrocannabinol (THC). GlyRs are pentameric ligand-gated chloride channels that control inhibitory neurotransmission in the brainstem and spinal cord. The glycinergic… read more here.
Keywords: based discovery; binding site; structure based; thc binding ... See more keywords