Theaflavin-3, 3'-digallate inhibits ovarian cancer stem cells via suppressing Wnt/β-Catenin signaling pathway.
Sign Up to like & getrecommendations! Published in 2018 at "Journal of functional foods"
DOI: 10.1016/j.jff.2018.09.021
Abstract: Recent evidence indicates that ovarian cancer stem cells (CSCs) are responsible for ovarian cancer recurrence and drug resistance, resulting in the low long-term survival rate of patients with advanced ovarian cancer. We aimed to study… read more here.
Keywords: cancer stem; cscs; ovarian cancer; theaflavin digallate ... See more keywords
Enhancing Intestinal Permeability of Theaflavin-3,3'-digallate by Chitosan-Caseinophosphopeptides Nanocomplexes.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of agricultural and food chemistry"
DOI: 10.1021/acs.jafc.1c07382
Abstract: Low intestinal permeability is an unfavorable feature that limits the bioavailability of many hydrophilic polyphenols. In this study, chitosan (CS) was used to complex with caseinophosphopeptides (CPPs), aiming to improve the intestinal permeability of theaflavin-3,3'-digallate… read more here.
Keywords: permeability; theaflavin digallate; intestinal permeability; permeability theaflavin ... See more keywords
Theaflavin‐3,3´‐digallate increases the antibacterial activity of β‐lactam antibiotics by inhibiting metallo‐β‐lactamase activity
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Cellular and Molecular Medicine"
DOI: 10.1111/jcmm.14580
Abstract: Metallo‐β‐lactamases (MBLs) are some of the best known β‐lactamases produced by common Gram‐positive and Gram‐negative pathogens and are crucial factors in the rise of bacterial resistance against β‐lactam antibiotics. Although many types of β‐lactamase inhibitors… read more here.
Keywords: lactam antibiotics; tfdg; antibacterial activity; theaflavin digallate ... See more keywords
Theaflavin-3,3′-Digallate Protects Cartilage from Degradation by Modulating Inflammation and Antioxidant Pathways
Sign Up to like & getrecommendations! Published in 2022 at "Oxidative Medicine and Cellular Longevity"
DOI: 10.1155/2022/3047425
Abstract: Background Osteoarthritis (OA) is a common degenerative joint disease that may be closely linked to inflammation and oxidative stress destroying the balance of cartilage matrix. Theaflavin-3,3′-digallate (TFDG), a natural substance derived from black tea, has… read more here.
Keywords: theaflavin digallate; inflammation; tfdg; cartilage degradation ... See more keywords
Theaflavin-3,3′-Digallate Plays a ROS-Mediated Dual Role in Ferroptosis and Apoptosis via the MAPK Pathway in Human Osteosarcoma Cell Lines and Xenografts
Sign Up to like & getrecommendations! Published in 2022 at "Oxidative Medicine and Cellular Longevity"
DOI: 10.1155/2022/8966368
Abstract: Globally, osteosarcoma (OS) is the most prevalent form of primary bone cancer in children and adolescents. Traditional neoadjuvant chemotherapy regimens have reached a bottleneck; thus, OS survivors have unsatisfactory outcomes. Theaflavin-3,3′-digallate (TF3) exhibits potent anticancer… read more here.
Keywords: theaflavin digallate; cell; tf3; mapk pathway ... See more keywords
Effects of Methylmercury and Theaflavin Digallate on Adipokines in Mature 3T3-L1 Adipocytes
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DOI: 10.3390/ijms20112755
Abstract: Diabetes is a contributor to morbidity across the globe and is often associated with obesity, metabolic syndrome and other inflammatory diseases associated with aging. In addition to genetic and lifestyle factors, environmental factors such as… read more here.
Keywords: methylmercury; 3t3 adipocytes; effects methylmercury; theaflavin digallate ... See more keywords
Antibacterial and Sporicidal Activity Evaluation of Theaflavin-3,3′-digallate
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DOI: 10.3390/ijms23042153
Abstract: Theaflavin-3,3′-digallate (TFDG), a polyphenol derived from the leaves of Camellia sinensis, is known to have many health benefits. In this study, the antibacterial effect of TFDG against nine bacteria and the sporicidal activities on spore-forming… read more here.
Keywords: theaflavin digallate; tfdg; antibacterial sporicidal; activity evaluation ... See more keywords
Improving Theaflavin-3,3′-digallate Production Efficiency Optimization by Transition State Conformation of Polyphenol Oxidase
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DOI: 10.3390/molecules28093831
Abstract: Theaflavins (TFs) are good for health because of their bioactivities. Enzymatic synthesis of TFs has garnered much attention; however, the source and activity of the enzymes needed limit their wide application. In this study, a… read more here.
Keywords: theaflavin digallate; transition state; polyphenol oxidase; conformation ... See more keywords