Theaflavin-3-gallate, a natural antagonist for Hsp90: In-silico and in-vitro approach.
Sign Up to like & getrecommendations! Published in 2021 at "Chemico-biological interactions"
DOI: 10.1016/j.cbi.2021.109774
Abstract: Poor prognosis and metastasis have been recognized as the major cause of breast cancer related deaths worldwide. Recent experimental evidence has shown that Hsp90, the prime chaperone, is overexpressed in many cancers and is responsible… read more here.
Keywords: cancer; hsp90; gallate; theaflavin gallate ... See more keywords
Theaflavin-3'-O-gallate a Black-tea Constituent Blocked SARS CoV-2 RNA dependant RNA Polymerase Active-site with Better Docking Results than Remdesivir.
Sign Up to like & getrecommendations! Published in 2021 at "Drug research"
DOI: 10.1055/a-1467-5828
Abstract: BACKGROUND Replication of SARS-CoV-2 depends on viral RNA-dependent RNA-polymerase (RdRp). Remdesivir, the broad-spectrum RdRp inhibitor acts as nucleoside-analogues (NAs). Remdesivir has initially been repurposed as a promising drug against SARS-CoV-2 infection with some health hazards… read more here.
Keywords: rna; rna polymerase; theaflavin gallate; site ... See more keywords