Paeoniflorin extract reverses dexamethasone-induced testosterone over-secretion through downregulation of cytochrome P450 17A1 expression in primary murine theca cells.
Sign Up to like & getrecommendations! Published in 2019 at "Journal of ethnopharmacology"
DOI: 10.1016/j.jep.2018.09.006
Abstract: ETHNOPHARMACOLOGICAL RELEVANCE Polycystic Ovarian Syndrome (PCOS) is a complex endocrine and reproductive disorder. A main hallmark includes increased androgen production. The root of Paeonia lactiflora Pall. (Bai Shao) is used in Chinese herbal medicine for… read more here.
Keywords: paeoniflorin extract; secretion; theca; theca cells ... See more keywords
Inhibition of autophagy in theca cells induces CYP17A1 and PAI-1 expression via ROS/p38 and JNK signalling during the development of polycystic ovary syndrome
Sign Up to like & getrecommendations! Published in 2020 at "Molecular and Cellular Endocrinology"
DOI: 10.1016/j.mce.2020.110792
Abstract: Polycystic ovary syndrome (PCOS) is a clinical syndrome characterized by hyperandrogenism, oligo/anovulation, and polycystic ovary. Autophagy is an intracellular system that degrades cytosolic proteins and organelles. The relationship between autophagy and PCOS has not been… read more here.
Keywords: polycystic ovary; jnk; inhibition; theca cells ... See more keywords
The effects of CLP-induced sepsis on proliferation and apoptosis of granulosa and theca cells in rat ovary: A histochemical and ultrastructural study.
Sign Up to like & getrecommendations! Published in 2020 at "Reproductive biology"
DOI: 10.1016/j.repbio.2020.04.003
Abstract: Sepsis is defined as a systemic inflammatory response to infection. This study is aimed to evaluate the effects of experimental sepsis on the proliferation and apoptosis of granulosa and theca cells in the rat ovary.… read more here.
Keywords: granulosa theca; sepsis; theca cells; apoptosis ... See more keywords
Anti-Müllerian hormone inhibits luteinizing hormone-induced androstenedione synthesis in porcine theca cells.
Sign Up to like & getrecommendations! Published in 2019 at "Theriogenology"
DOI: 10.1016/j.theriogenology.2019.10.037
Abstract: AMH (Anti-Müllerian Hormone) is involved in the regulation of follicle growth initiation and inhibits FSH-induced aromatase expression and estrogen production in granulosa cells. However, the function of AMH in steroidogenesis by theca cells remains unclear.… read more here.
Keywords: hormone; anti llerian; production; theca cells ... See more keywords
Surface mechanics and compressive stress impact mammalian follicle development
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DOI: 10.1038/s41467-025-65390-y
Abstract: The maturation of functional eggs in ovaries is essential for successful reproduction in mammals. Despite its biological and clinical importance, the underlying mechanisms regulating folliculogenesis remain enigmatic. Here, using murine ovaries, we report that the… read more here.
Keywords: follicle; mechanics; cell; theca cells ... See more keywords
Establishment of an in vitro culture model of theca cells from hierarchical follicles in ducks
Sign Up to like & getrecommendations! Published in 2017 at "Bioscience Reports"
DOI: 10.1042/bsr20160491
Abstract: Theca cells, including theca interna cells and theca externa cells, are vital components of ovarian follicles. The aim of the present study is to identify a reliable method for the in vitro culture of theca… read more here.
Keywords: phase; vitro culture; theca; theca cells ... See more keywords
PSX-A-24 Late-Breaking: Testosterone production by theca cells of large preovulatory follicles is affected by growth hormone depending on the hen age and the presence of granulosa cells
Sign Up to like & getrecommendations! Published in 2021 at "Journal of Animal Science"
DOI: 10.1093/jas/skab235.674
Abstract: Testosterone produced by theca cells may be involved in regulating of the growth and ovulation of hen preovulatory follicles (Rangel, Gutierrez, Gen Comp Endocrinol, 203:250, 2014). In the current research, we studied effects of growth… read more here.
Keywords: preovulatory follicles; production; presence; testosterone ... See more keywords
Where are the theca cells from: the mechanism of theca cells derivation and differentiation
Sign Up to like & getrecommendations! Published in 2020 at "Chinese Medical Journal"
DOI: 10.1097/cm9.0000000000000850
Abstract: Abstract Mammalian follicles are composed of oocytes, granulosa cells, and theca cells. Theca cells form in the secondary follicles, maintaining follicular structural integrity and secreting steroid hormones. Two main sources of theca cells exist: Wilms… read more here.
Keywords: cells theca; cells mechanism; theca; differentiation theca ... See more keywords
Transcriptomic analysis of theca cells in a PCOS rat model: insights into follicular development
Sign Up to like & getrecommendations! Published in 2025 at "Journal of Ovarian Research"
DOI: 10.1186/s13048-025-01663-w
Abstract: This study aimed to analyze differentially expressed genes in theca cells of polycystic ovary syndrome (PCOS) rats using transcriptomic sequencing. Bioinformatics analysis and PCR validation were performed to identify genes involved in follicular development regulation… read more here.
Keywords: analysis; follicular development; theca cells; pcos ... See more keywords
Colocalization of Polycystic Ovary Syndrome Candidate Gene Products in Theca Cells Suggests Novel Signaling Pathways
Sign Up to like & getrecommendations! Published in 2019 at "Journal of the Endocrine Society"
DOI: 10.1210/js.2019-00169
Abstract: Abstract Genome-wide association studies identified loci associated with polycystic ovary syndrome (PCOS), including those near the LH receptor gene (LHCGR), a clathrin-binding protein (DENND1A) that functions as a guanine nucleotide exchange factor, and the gene… read more here.
Keywords: polycystic ovary; dennd1a; theca cells; ovary syndrome ... See more keywords
MON-202 Changes in the Expression of Epigenetic Enzymes Induced by Prenatal Testosterone Excess May Underlie the Antral Follicular Defects in the Sheep Model of PCOS
Sign Up to like & getrecommendations! Published in 2019 at "Journal of the Endocrine Society"
DOI: 10.1210/js.2019-mon-202
Abstract: Abstract Prenatal testosterone (T) excess leads to oligo/anovulation and multifollicular ovary in sheep, characteristics of women with PCOS. Persistence of antral follicles - the result of reduced atresia, follicular growth arrest and premature luteinization, contribute… read more here.
Keywords: expression; changes expression; granulosa; cell ... See more keywords