Screening of Prototype Antiseizure and Anti-Inflammatory Compounds in the Theiler's Murine Encephalomyelitis Virus Model of Epilepsy.
Sign Up to like & getrecommendations! Published in 2021 at "Epilepsia open"
DOI: 10.1002/epi4.12550
Abstract: OBJECTIVE Infection with Theiler's Murine Encephalomyelitis Virus (TMEV) in C57Bl/6J mice results in handling-induced seizures and is useful for evaluating compounds effective against infection-induced seizures. However, to date only a few compounds have been evaluated… read more here.
Keywords: anti inflammatory; encephalomyelitis virus; murine encephalomyelitis; inflammatory compounds ... See more keywords
Gut dysbiosis and neuroimmune responses to brain infection with Theiler’s murine encephalomyelitis virus
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DOI: 10.1038/srep44377
Abstract: Recent studies have begun to point out the contribution of microbiota to multiple sclerosis (MS) pathogenesis. Theiler’s murine encephalomyelitis virus induced demyelinating disease (TMEV-IDD) is a model of progressive MS. Here, we first analyze the… read more here.
Keywords: encephalomyelitis virus; murine encephalomyelitis; tmev; theiler murine ... See more keywords
Host genetic diversity drives variable central nervous system lesion distribution in chronic phase of Theiler’s Murine Encephalomyelitis Virus (TMEV) infection
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DOI: 10.1371/journal.pone.0256370
Abstract: Host genetic background is a significant driver of the variability in neurological responses to viral infection. Here, we leverage the genetically diverse Collaborative Cross (CC) mouse resource to better understand how chronic infection by Theiler’s… read more here.
Keywords: host genetic; infection; lesion distribution; theiler murine ... See more keywords
Facets of Theiler’s Murine Encephalomyelitis Virus-Induced Diseases: An Update
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DOI: 10.3390/ijms20020448
Abstract: Theiler’s murine encephalomyelitis virus (TMEV), a naturally occurring, enteric pathogen of mice is a Cardiovirus of the Picornaviridae family. Low neurovirulent TMEV strains such as BeAn cause a severe demyelinating disease in susceptible SJL mice… read more here.
Keywords: encephalomyelitis virus; murine encephalomyelitis; induced diseases; theiler murine ... See more keywords