Thioesterase Superfamily Member 2 Promotes Hepatic VLDL Secretion by Channeling Fatty Acids Into Triglyceride Biosynthesis
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DOI: 10.1002/hep.30411
Abstract: In nonalcoholic fatty liver disease (NAFLD), triglycerides accumulate within the liver because the rates of fatty acid accrual by uptake from plasma and de novo synthesis exceed elimination by mitochondrial oxidation and secretion as very… read more here.
Keywords: vldl secretion; fatty acids; them2; superfamily member ... See more keywords
Upregulation of Thioesterase Superfamily Member 2 in Skeletal Muscle Promotes Hepatic Steatosis and Insulin Resistance.
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DOI: 10.1002/hep.32122
Abstract: BACKGROUND & AIMS Thioesterase superfamily member 2 (Them2) is highly expressed in liver and oxidative tissues, where it hydrolyzes long chain fatty acyl-CoA esters to free fatty acids and CoA. Although mice globally lacking Them2… read more here.
Keywords: skeletal muscle; hepatic steatosis; insulin; them2 ... See more keywords