THEMIS increases TCR signaling in CD4+CD8+ thymocytes by inhibiting the activity of the tyrosine phosphatase SHP1
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DOI: 10.1126/scisignal.ade1274
Abstract: The T cell lineage–restricted protein THEMIS plays a critical role in T cell development at the positive selection stage. In the SHP1 activation model, THEMIS is proposed to enhance the activity of the tyrosine phosphatase… read more here.
Keywords: cd4 cd8; themis; tcr signaling; selection ... See more keywords