Synthon hierarchy in theobromine cocrystals with hydroxybenzoic acids as coformers
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DOI: 10.1039/c9ce01195a
Abstract: Cocrystals, solids composed of molecular and/or ionic compounds connected by noncovalent interactions, are objects of interest in crystal engineering. Theobromine, as an active pharmaceutical ingredient, was used in cocrystallization with dihydroxybenzoic acids. read more here.
Keywords: theobromine; hydroxybenzoic acids; synthon hierarchy; hierarchy theobromine ... See more keywords
Theobromine ameliorates nonalcoholic fatty liver disease by regulating hepatic lipid metabolism via mTOR signaling pathway in vivo and in vitro.
Sign Up to like & getrecommendations! Published in 2020 at "Canadian journal of physiology and pharmacology"
DOI: 10.1139/cjpp-2020-0259
Abstract: Theobromine, a methylxanthine present in cocoa, has been shown to possess many beneficial pharmacological properties such as anti-oxidative stress, anti-inflammatory property, and anti-microbial activity. In this study, we investigated the effects of theobromine on NAFLD… read more here.
Keywords: vivo vitro; theobromine; fatty acid; mtor signaling ... See more keywords
3-Methylxanthine production through biodegradation of theobromine by Aspergillus sydowii PT-2
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DOI: 10.1186/s12866-020-01951-z
Abstract: Background Methylxanthines, including caffeine, theobromine and theophylline, are natural and synthetic compounds in tea, which could be metabolized by certain kinds of bacteria and fungi. Previous studies confirmed that several microbial isolates from Pu-erh tea… read more here.
Keywords: theobromine; methylxanthine production; demethylation; aspergillus sydowii ... See more keywords
Immunostimulatory Activities of Theobromine on Macrophages via the Activation of MAPK and NF-κB Signaling Pathways
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DOI: 10.3390/cimb44090289
Abstract: Theobromine is mainly found in plant foods, such as tea; the primary source of theobromine is the seeds of the Theobroma cacao tree. Theobromine is an alkaloid belonging to the methylxanthine class of drugs, and… read more here.
Keywords: activities theobromine; theobromine macrophages; theobromine; immunostimulatory activities ... See more keywords
Artificial Caries Lesion Characteristics after Secondary Demineralization with Theobromine-Containing Protocol
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DOI: 10.3390/molecules26020300
Abstract: Developing artificial caries lesions with varying characteristics is needed to adequately study caries process in vitro. The objective of this study was to investigate artificial caries lesion characteristics after secondary demineralization protocol containing theobromine and… read more here.
Keywords: theobromine; artificial caries; lesion characteristics; demineralization ... See more keywords
New Anticancer Theobromine Derivative Targeting EGFRWT and EGFRT790M: Design, Semi-Synthesis, In Silico, and In Vitro Anticancer Studies
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DOI: 10.3390/molecules27185859
Abstract: Based on the pharmacophoric features of EGFR inhibitors, a new semisynthetic theobromine-derived compound was designed to interact with the catalytic pocket of EGFR. Molecular docking against wild (EGFRWT; PDB: 4HJO) and mutant (EGFRT790M; PDB: 3W2O)… read more here.
Keywords: compound; silico; theobromine derivative; theobromine ... See more keywords