Towards a unified mechanistic theory of aging
Sign Up to like & getrecommendations! Published in 2019 at "Experimental Gerontology"
DOI: 10.1016/j.exger.2019.05.016
Abstract: A large amount of the longevity-modulating genes discovered during the last two decades are highly conserved during evolution from yeast and invertebrates to mammals. Many different kinds of evidence converge in the concept that life… read more here.
Keywords: longevity; unified mechanistic; theory aging; towards unified ... See more keywords
Updating the Free Radical Theory of Aging
Sign Up to like & getrecommendations! Published in 2020 at "Frontiers in Cell and Developmental Biology"
DOI: 10.3389/fcell.2020.575645
Abstract: The free radical theory of aging, one of the nine suggested hallmarks of aging (López-Otín et al., 2016), implicates the gradual accumulation of oxidative cellular damage as a fundamental driver of cellular aging (Harman, 1956;… read more here.
Keywords: theory; theory aging; radical theory; free radical ... See more keywords
The Danaid Theory of Aging
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Cell and Developmental Biology"
DOI: 10.3389/fcell.2021.671208
Abstract: The classical evolutionary theories of aging suggest that aging evolves due to insufficient selective pressure against it. In these theories, declining selection pressure with age leads to aging through genes or resource allocations, implying that… read more here.
Keywords: theory; biology; theory aging; danaid theory ... See more keywords