Noncovalent Theranostic Prodrug for Hypoxia-Activated Drug Delivery and Real-Time Tracking.
Sign Up to like & getrecommendations! Published in 2021 at "Analytical chemistry"
DOI: 10.1021/acs.analchem.1c03153
Abstract: Real-time tracking of hypoxia-activated prodrugs (HAPs) delivery and the release process is of great significance for innovative medical treatments and drug development. Existing theranostic methods for HAPs activation imaging are based on the covalent approach,… read more here.
Keywords: drug; drug delivery; hypoxia activated; theranostic prodrug ... See more keywords
Hypoxia-activated and indomethacin-mediated theranostic prodrug releasing drug on-demand for tumor imaging and therapy.
Sign Up to like & getrecommendations! Published in 2019 at "Bioconjugate chemistry"
DOI: 10.1021/acs.bioconjchem.9b00564
Abstract: A smart theranostic prodrug IMC-FDU-TZBC-NO2, releasing active drug on-demand based on hypoxia-activated and indomethacin-mediated, for solid tumor imaging and efficient therapy was designed. This prodrug was constructed by conjugating of chemotherapy drug 5-fluoro-2-deoxyuridine (FDU), targeting… read more here.
Keywords: tumor; drug; theranostic prodrug; hypoxia ... See more keywords