Therapeutic activity of plant-derived alkaloid conophylline on metabolic syndrome and neurodegenerative disease models
Sign Up to like & getrecommendations! Published in 2017 at "Human Cell"
DOI: 10.1007/s13577-017-0196-4
Abstract: Increasing metabolic syndromes including type-2 diabetes mellitus, obesity, and steatohepatitis are serious problems in most countries in the world. Neurodegenerative diseases such as Alzheimer, Parkinson’s, and Huntington’s diseases are increasing in many countries. However, therapy… read more here.
Keywords: derived alkaloid; plant derived; alkaloid conophylline; activity plant ... See more keywords
Potential therapeutic activity of Phlogacanthus thyrsiformis Hardow (Mabb) flower extract and its biofabricated silver nanoparticles against chemically induced urolithiasis in male Wistar rats.
Sign Up to like & getrecommendations! Published in 2017 at "International journal of biological macromolecules"
DOI: 10.1016/j.ijbiomac.2017.05.096
Abstract: Urolithiasis is a painful disorder in which stones are formed in the kidney, bladder or urethra. There are no proper therapeutic treatments available for kidney stones and people suffering from larger stones have to undergo… read more here.
Keywords: silver nanoparticles; biofabricated silver; calcium oxalate; therapeutic activity ... See more keywords
Therapeutic activity of a Salmonella-vectored Schistosoma mansoni vaccine in a mouse model of chronic infection.
Sign Up to like & getrecommendations! Published in 2021 at "Vaccine"
DOI: 10.1016/j.vaccine.2021.08.031
Abstract: Schistosomiasis is an important fresh-water-borne parasitic disease caused by trematode worms of the genus Schistosoma. With > 250 million people infected worldwide and approximately 800 million people at risk, the World Health Organization considers schistosomiasis to be… read more here.
Keywords: catb; salmonella; infection; model ... See more keywords
The National Cancer Institute ALMANAC: A Comprehensive Screening Resource for the Detection of Anticancer Drug Pairs with Enhanced Therapeutic Activity.
Sign Up to like & getrecommendations! Published in 2017 at "Cancer research"
DOI: 10.1158/0008-5472.can-17-0489
Abstract: To date, over 100 small-molecule oncology drugs have been approved by the FDA. Because of the inherent heterogeneity of tumors, these small molecules are often administered in combination to prevent emergence of resistant cell subpopulations.… read more here.
Keywords: detection; resource; drug; cancer ... See more keywords
Abstract 4408: Metabolic alterations induced by ibrutinib in CLL cells as a basis for drug combinations to enhance ibrutinib therapeutic activity
Sign Up to like & getrecommendations! Published in 2017 at "Cancer Research"
DOI: 10.1158/1538-7445.am2017-4408
Abstract: The use of ibrutinib, which targets the Bruton tyrosine kinase, has significantly improved the therapeutic outcome for patients with chronic lymphocytic leukemia (CLL), especially in cases with chromosome 17p deletion, which usually respond poorly to… read more here.
Keywords: cll; metabolic alterations; drug; cll cells ... See more keywords
Potent universal beta-coronavirus therapeutic activity mediated by direct respiratory administration of a Spike S2 domain-specific human neutralizing monoclonal antibody
Sign Up to like & getrecommendations! Published in 2022 at "PLoS Pathogens"
DOI: 10.1371/journal.ppat.1010691
Abstract: Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2) marks the third novel β-coronavirus to cause significant human mortality in the last two decades. Although vaccines are available, too few have been administered worldwide to keep the virus… read more here.
Keywords: specific human; coronavirus; spike domain; sars cov ... See more keywords
AADAC promotes therapeutic activity of cisplatin and imatinib against ovarian cancer cells.
Sign Up to like & getrecommendations! Published in 2022 at "Histology and histopathology"
DOI: 10.14670/hh-18-460
Abstract: OBJECTIVE To explore how AADAC functions in the malignant progression of ovarian cancer, and the effect of AADAC on drug therapeutic activity against ovarian cancer cells. METHODS AADAC level in tumor and normal samples from… read more here.
Keywords: ovarian cancer; cancer cells; cancer; cisplatin imatinib ... See more keywords