A drug‐repositioning screen for primary pancreatic ductal adenocarcinoma cells identifies 6‐thioguanine as an effective therapeutic agent for TPMT‐low cancer cells
Sign Up to like & getrecommendations! Published in 2018 at "Molecular Oncology"
DOI: 10.1002/1878-0261.12364
Abstract: Pancreatic cancer is one of the most difficult cancers to cure due to the lack of early diagnostic tools and effective therapeutic agents. In this study, we aimed to isolate new bioactive compounds that effectively… read more here.
Keywords: therapeutic agent; ductal adenocarcinoma; pancreatic ductal; cancer cells ... See more keywords
RNA-cleaving DNAzymes as a diagnostic and therapeutic agent against antimicrobial resistant bacteria.
Sign Up to like & getrecommendations! Published in 2021 at "Current genetics"
DOI: 10.1007/s00294-021-01212-0
Abstract: The development of nucleic-acid-based antimicrobials such as RNA-cleaving DNAzyme (RCD), a short catalytically active nucleic acid, is a promising alternative to the current antibiotics. The current rapid spread of antimicrobial resistance (AMR) in bacteria renders… read more here.
Keywords: therapeutic agent; agent; diagnostic therapeutic; dnazymes diagnostic ... See more keywords
Therapeutic agent-based infinite coordination polymer nanomedicines for tumor therapy
Sign Up to like & getrecommendations! Published in 2021 at "Coordination Chemistry Reviews"
DOI: 10.1016/j.ccr.2021.214059
Abstract: Abstract Infinite coordination polymer (ICP) is an amorphous compound formed by the coordination between ligands and metal ions. Among them, the therapeutic agent as the ligand of ICP is called ICP nanomedicines. In recent years,… read more here.
Keywords: tumor therapy; therapeutic agent; coordination; tumor ... See more keywords
Endolysins as emerging alternative therapeutic agent to counter drug resistant infections.
Sign Up to like & getrecommendations! Published in 2019 at "International journal of antimicrobial agents"
DOI: 10.1016/j.ijantimicag.2019.11.001
Abstract: Endolysins are the lytic products of bacteriophage, which play a specific role in the release of phage progeny by degrading the peptidoglycan of host bacterium. In the light of antibiotic resistance, endolysins are being considered… read more here.
Keywords: therapeutic agent; drug resistant; endolysins emerging; alternative therapeutic ... See more keywords
THE DNA-BASED THERAPEUTIC AGENT BC 007 COMPLETELY NEUTRALIZES AGONISTIC AUTOANTIBODIES DIRECTED AGAINST β1-ADRENOCEPTORS: RESULTS OF A PHASE 1 TRIAL
Sign Up to like & getrecommendations! Published in 2018 at "Journal of the American College of Cardiology"
DOI: 10.1016/s0735-1097(18)31186-0
Abstract: 80 percent of patients with non-ischemic heart failure (HF) and reduced ejection fraction have autoantibodies against β1-adrenoceptos (β1-AAB), which cause and/or sustain HF. The removal of β1-AAB by immunoadsorption (IA) leads to an improvement of… read more here.
Keywords: therapeutic agent; dna based; completely neutralizes; 007 completely ... See more keywords
CO as a therapeutic agent: discovery and delivery forms.
Sign Up to like & getrecommendations! Published in 2020 at "Chinese journal of natural medicines"
DOI: 10.1016/s1875-5364(20)30036-4
Abstract: Carbon monoxide (CO) as one of the three important endogenously produced signaling molecules, termed as "gasotransmitter," has emerged as a promising therapeutic agent for treating various inflammation and cellular-stress related diseases. In this review, we… read more here.
Keywords: discovery delivery; therapeutic agent; agent discovery; delivery forms ... See more keywords
Kefir as a therapeutic agent in clinical research: a scoping review.
Sign Up to like & getrecommendations! Published in 2023 at "Nutrition research reviews"
DOI: 10.1017/s0954422423000070
Abstract: Increasing research has been conducted on the role of probiotics in disease treatment. Kefir, a safe, low-cost probiotic fermented milk drink, has been investigated in many in vitro and animal studies, although parameters for human… read more here.
Keywords: scoping review; therapeutic agent; kefir therapeutic; research ... See more keywords
A Multifunctional Molecular Therapeutic Agent for Targeted and Controlled Dual Chemo- and Photodynamic Therapy.
Sign Up to like & getrecommendations! Published in 2020 at "Journal of medicinal chemistry"
DOI: 10.1021/acs.jmedchem.0c00893
Abstract: A novel molecular therapeutic agent was designed and synthesized which contains three functional components, namely a zinc(II) phthalocyanine substituted with a 2,4-dinitrobenzenesulfonate (DNBS) group as a glutathione (GSH)-activated photosensitizer, a chemo-prodrug based on combretastatin A-4… read more here.
Keywords: therapeutic agent; multifunctional molecular; chemo; molecular therapeutic ... See more keywords
Self-Assembling Porphyrins as a Single Therapeutic Agent for Synergistic Cancer Therapy: A One Stone Three Birds Strategy.
Sign Up to like & getrecommendations! Published in 2021 at "ACS applied materials & interfaces"
DOI: 10.1021/acsami.1c04868
Abstract: Combining photodynamic therapy (PDT), chemodynamic therapy (CDT), and ferroptosis is a valuable means for an enhanced anticancer effect. However, traditional combination of PDT/CDT/ferroptosis faces several hurdles, including excess glutathione (GSH) neutralization and preparation complexity. In… read more here.
Keywords: therapeutic agent; single therapeutic; cdt ferroptosis; pdt ... See more keywords
A VCP modulator, KUS121, as a promising therapeutic agent for post-traumatic osteoarthritis
Sign Up to like & getrecommendations! Published in 2020 at "Scientific Reports"
DOI: 10.1038/s41598-020-77735-2
Abstract: Post-traumatic osteoarthritis (PTOA) is a major cause which hinders patients from the recovery after intra-articular injuries or surgeries. Currently, no effective treatment is available. In this study, we showed that inhibition of the acute stage… read more here.
Keywords: post traumatic; therapeutic agent; traumatic osteoarthritis; ptoa ... See more keywords
An important call: Suggestion of using IL-10 as therapeutic agent for COVID-19 with ARDS and other complications
Sign Up to like & getrecommendations! Published in 2023 at "Virulence"
DOI: 10.1080/21505594.2023.2190650
Abstract: ABSTRACT The global coronavirus disease 2019 (COVID-19) pandemic has a detrimental impact on public health. COVID-19 usually manifests as pneumonia, which can progress into acute respiratory distress syndrome (ARDS) related to uncontrolled TH17 immune reaction.… read more here.
Keywords: important call; call suggestion; agent; covid ... See more keywords