Estimated Costs of Pivotal Trials for Novel Therapeutic Agents Approved by the US Food and Drug Administration, 2015-2016
Sign Up to like & getrecommendations! Published in 2018 at "JAMA Internal Medicine"
DOI: 10.1001/jamainternmed.2018.3931
Abstract: Importance A critical question in health care is the extent of scientific evidence that should be required to establish that a new therapeutic agent has benefits that outweigh its risks. Estimating the costs of this… read more here.
Keywords: trial; drug; million million; 2015 2016 ... See more keywords
Self‐Assembled Nanoparticles as Cancer Therapeutic Agents
Sign Up to like & getrecommendations! Published in 2020 at "Advanced Materials Interfaces"
DOI: 10.1002/admi.202001602
Abstract: Most therapeutic agents for cancer are currently suffering from the shortcomings of poor solubility, severe side effects, and multidrug resistance. Supramolecular self‐assembly (SSA) in nanomedicines is a promising way to overcome these obstacles due to… read more here.
Keywords: cancer; self assembled; assembled nanoparticles; therapeutic agents ... See more keywords
The role of viruses in cancer development versus cancer therapy: An oncological perspective.
Sign Up to like & getrecommendations! Published in 2023 at "Cancer medicine"
DOI: 10.1002/cam4.5694
Abstract: Despite great medical advances, oncological research is still looking for novel therapeutic approaches due to the limitation of conventional therapeutic agents. Virotherapy is one of these new emerging therapeutic approaches that attract attention with their… read more here.
Keywords: therapy; virotherapy agents; therapeutic agents; cancer therapy ... See more keywords
Targeting mitochondrial metabolism for metastatic cancer therapy
Sign Up to like & getrecommendations! Published in 2022 at "Molecular Carcinogenesis"
DOI: 10.1002/mc.23436
Abstract: Primary tumors evolve metabolic mechanisms favoring glycolysis for adenosine triphosphate (ATP) generation and antioxidant defenses. In contrast, metastatic cells frequently depend on mitochondrial respiration and oxidative phosphorylation (OxPhos). This reliance of metastatic cells on OxPhos… read more here.
Keywords: mitochondrial metabolism; metastatic cancer; therapeutic agents; tumor ... See more keywords
Poly(N-phenylglycine)-Based Nanoparticles as Highly Effective and Targeted Near-Infrared Photothermal Therapy/Photodynamic Therapeutic Agents for Malignant Melanoma.
Sign Up to like & getrecommendations! Published in 2017 at "Small"
DOI: 10.1002/smll.201602496
Abstract: Malignant melanoma is a highly aggressive tumor resistant to chemotherapy. Therefore, the development of new highly effective therapeutic agents for the treatment of malignant melanoma is highly desirable. In this study, a new class of… read more here.
Keywords: melanoma; phenylglycine; highly effective; malignant melanoma ... See more keywords
Therapeutic agents from endophytes harbored in Asian medicinal plants
Sign Up to like & getrecommendations! Published in 2020 at "Phytochemistry Reviews"
DOI: 10.1007/s11101-020-09683-8
Abstract: Endophytes are a diverse group of microorganisms present in plant tissues which include fungi and bacteria and have been utilized as therapeutic agents. They are known to produce different secondary and primary metabolites, which can… read more here.
Keywords: asian medicinal; medicinal plants; agents endophytes; endophytes harbored ... See more keywords
Emerging therapeutic agents in osteoarthritis.
Sign Up to like & getrecommendations! Published in 2019 at "Biochemical pharmacology"
DOI: 10.1016/j.bcp.2019.02.034
Abstract: Osteoarthritis (OA) is the most common joint disorder and a leading cause of disability. Current treatments for OA can improve symptoms but do not delay the progression of disease. In the last years, much effort… read more here.
Keywords: pharmacology; therapeutic agents; emerging therapeutic; agents osteoarthritis ... See more keywords
Natural therapeutic agents for neurodegenerative diseases from the shells of Xanthoceras sorbifolium.
Sign Up to like & getrecommendations! Published in 2020 at "Bioorganic chemistry"
DOI: 10.1016/j.bioorg.2020.104038
Abstract: Neuroinflammation is linked to neurodegenerative diseases, manifested by the microglial-released over-production of nitric oxide (NO). However, so far there is no effective strategy regarding curing or preventing neurodegenerative diseases. Triterpene saponins from Xanthoceras sorbifolium were… read more here.
Keywords: xanthoceras sorbifolium; neurodegenerative diseases; natural therapeutic; diseases shells ... See more keywords
Kinetically-inert polypyridylruthenium(II) complexes as therapeutic agents
Sign Up to like & getrecommendations! Published in 2018 at "Coordination Chemistry Reviews"
DOI: 10.1016/j.ccr.2017.11.011
Abstract: Abstract Due to the clinical success and limitations of platinum-based anticancer drugs, there has been considerable interest in the development of new therapeutic agents based upon other transition metals, in particular ruthenium. There have now… read more here.
Keywords: polypyridylruthenium; complexes therapeutic; inert polypyridylruthenium; polypyridylruthenium complexes ... See more keywords
Exploration of In-silico screening of therapeutic agents against SARS-CoV-2
Sign Up to like & getrecommendations! Published in 2021 at "Chemical Physics"
DOI: 10.1016/j.chemphys.2021.111354
Abstract: In the present investigation, molecular docking studies have been performed using AutoDock Vina to investigate the role of ligand-binding affinity at the hydrophobic pocket of COVID-19. The knowledge of the binding of protein receptors with… read more here.
Keywords: exploration silico; hydroxamic acids; silico screening; sars cov ... See more keywords
Therapeutic agents for targeting desmoplasia: current status and emerging trends.
Sign Up to like & getrecommendations! Published in 2020 at "Drug discovery today"
DOI: 10.1016/j.drudis.2020.09.008
Abstract: Desmoplasia is a major barrier to chemotherapy in several cancers, particularly pancreatic ductal adenocarcinoma and breast cancer. Tumors comprise cellular and noncellular components and chemoresistant cancer stem cells (CSCs) with established signaling pathways. In this… read more here.
Keywords: targeting desmoplasia; current status; desmoplasia; agents targeting ... See more keywords