Estimated Costs of Pivotal Trials for Novel Therapeutic Agents Approved by the US Food and Drug Administration, 2015-2016
Sign Up to like & getrecommendations! Published in 2018 at "JAMA Internal Medicine"
DOI: 10.1001/jamainternmed.2018.3931
Abstract: Importance A critical question in health care is the extent of scientific evidence that should be required to establish that a new therapeutic agent has benefits that outweigh its risks. Estimating the costs of this… read more here.
Keywords: trial; drug; million million; 2015 2016 ... See more keywords
Self‐Assembled Nanoparticles as Cancer Therapeutic Agents
Sign Up to like & getrecommendations! Published in 2020 at "Advanced Materials Interfaces"
DOI: 10.1002/admi.202001602
Abstract: Most therapeutic agents for cancer are currently suffering from the shortcomings of poor solubility, severe side effects, and multidrug resistance. Supramolecular self‐assembly (SSA) in nanomedicines is a promising way to overcome these obstacles due to… read more here.
Keywords: cancer; self assembled; assembled nanoparticles; therapeutic agents ... See more keywords
Hydroxypropyl methacrylate stars as versatile carriers of therapeutic agents
Sign Up to like & getrecommendations! Published in 2024 at "Journal of Applied Polymer Science"
DOI: 10.1002/app.55305
Abstract: Three star‐like carriers with poly(hydroxy propyl methacrylate) (PHPMA) cores and poly(oligoethylene glycol methacrylate) (POEGMA) arms as nanocarriers were utilized for the encapsulation of rhodamine B, resveratrol, and curcumin. These drugs differ in hydrophobicity and therapeutic… read more here.
Keywords: carriers therapeutic; versatile carriers; methacrylate stars; therapeutic agents ... See more keywords
Current Landscape of Novel Therapeutic Agents and Drug Targets in Irritable Bowel Syndrome
Sign Up to like & getrecommendations! Published in 2025 at "Archiv der Pharmazie"
DOI: 10.1002/ardp.70133
Abstract: Irritable bowel disease or syndrome (IBD/IBS) is a prevalent gastrointestinal tract problem affecting approximately 4% of the total population of the world. Choosing effective pharmacological treatments for IBS is still challenging due to the existence… read more here.
Keywords: drug targets; agents drug; drug; novel therapeutic ... See more keywords
The role of viruses in cancer development versus cancer therapy: An oncological perspective.
Sign Up to like & getrecommendations! Published in 2023 at "Cancer medicine"
DOI: 10.1002/cam4.5694
Abstract: Despite great medical advances, oncological research is still looking for novel therapeutic approaches due to the limitation of conventional therapeutic agents. Virotherapy is one of these new emerging therapeutic approaches that attract attention with their… read more here.
Keywords: therapy; virotherapy agents; therapeutic agents; cancer therapy ... See more keywords
Signaling Pathways and Promising Small‐Molecule Therapeutic Agents for Ischemic Stroke
Sign Up to like & getrecommendations! Published in 2025 at "ChemMedChem"
DOI: 10.1002/cmdc.202400975
Abstract: Stroke is the second highest cause of death and leading cause of disability with high economic burden worldwide. The incidence of stroke is increasing faster and more prevalent for the global population over age 65.… read more here.
Keywords: signaling pathways; signalling pathways; ischemic stroke; stroke ... See more keywords
Targeting mitochondrial metabolism for metastatic cancer therapy
Sign Up to like & getrecommendations! Published in 2022 at "Molecular Carcinogenesis"
DOI: 10.1002/mc.23436
Abstract: Primary tumors evolve metabolic mechanisms favoring glycolysis for adenosine triphosphate (ATP) generation and antioxidant defenses. In contrast, metastatic cells frequently depend on mitochondrial respiration and oxidative phosphorylation (OxPhos). This reliance of metastatic cells on OxPhos… read more here.
Keywords: mitochondrial metabolism; metastatic cancer; therapeutic agents; tumor ... See more keywords
Poly(N-phenylglycine)-Based Nanoparticles as Highly Effective and Targeted Near-Infrared Photothermal Therapy/Photodynamic Therapeutic Agents for Malignant Melanoma.
Sign Up to like & getrecommendations! Published in 2017 at "Small"
DOI: 10.1002/smll.201602496
Abstract: Malignant melanoma is a highly aggressive tumor resistant to chemotherapy. Therefore, the development of new highly effective therapeutic agents for the treatment of malignant melanoma is highly desirable. In this study, a new class of… read more here.
Keywords: melanoma; phenylglycine; highly effective; malignant melanoma ... See more keywords
Therapeutic agents from endophytes harbored in Asian medicinal plants
Sign Up to like & getrecommendations! Published in 2020 at "Phytochemistry Reviews"
DOI: 10.1007/s11101-020-09683-8
Abstract: Endophytes are a diverse group of microorganisms present in plant tissues which include fungi and bacteria and have been utilized as therapeutic agents. They are known to produce different secondary and primary metabolites, which can… read more here.
Keywords: asian medicinal; medicinal plants; agents endophytes; endophytes harbored ... See more keywords
Emerging therapeutic agents in osteoarthritis.
Sign Up to like & getrecommendations! Published in 2019 at "Biochemical pharmacology"
DOI: 10.1016/j.bcp.2019.02.034
Abstract: Osteoarthritis (OA) is the most common joint disorder and a leading cause of disability. Current treatments for OA can improve symptoms but do not delay the progression of disease. In the last years, much effort… read more here.
Keywords: pharmacology; therapeutic agents; emerging therapeutic; agents osteoarthritis ... See more keywords
Natural therapeutic agents for neurodegenerative diseases from the shells of Xanthoceras sorbifolium.
Sign Up to like & getrecommendations! Published in 2020 at "Bioorganic chemistry"
DOI: 10.1016/j.bioorg.2020.104038
Abstract: Neuroinflammation is linked to neurodegenerative diseases, manifested by the microglial-released over-production of nitric oxide (NO). However, so far there is no effective strategy regarding curing or preventing neurodegenerative diseases. Triterpene saponins from Xanthoceras sorbifolium were… read more here.
Keywords: xanthoceras sorbifolium; neurodegenerative diseases; natural therapeutic; diseases shells ... See more keywords