Strategies to control therapeutic antibody glycosylation during bioprocessing: Synthesis and separation
Sign Up to like & getrecommendations! Published in 2022 at "Biotechnology and Bioengineering"
DOI: 10.1002/bit.28066
Abstract: Glycosylation can be a critical quality attribute in biologic manufacturing. In particular, it has implications on the halfâlife, immunogenicity, and pharmacokinetics of therapeutic monoclonal antibodies (mAbs), and must be closely monitored throughout drug development and… read more here.
Keywords: therapeutic antibody; antibody glycosylation; glycosylation; downstream ... See more keywords
Emerging Strategies for Therapeutic Antibody Discovery from Human B Cells.
Sign Up to like & getrecommendations! Published in 2020 at "Advances in experimental medicine and biology"
DOI: 10.1007/978-981-15-4494-1_18
Abstract: Monoclonal antibodies from human sources are being increasingly recognized as valuable options in many therapeutic areas. These antibodies can show exquisite specificity and high potency while maintaining a desirable safety profile, having been matured and… read more here.
Keywords: strategies therapeutic; emerging strategies; antibody; discovery human ... See more keywords
Therapeutic antibody targeting of indoleamine-2,3-dioxygenase (IDO2) inhibits autoimmune arthritis.
Sign Up to like & getrecommendations! Published in 2017 at "Clinical immunology"
DOI: 10.1016/j.clim.2017.01.016
Abstract: Rheumatoid arthritis (RA) is a debilitating inflammatory autoimmune disease with no known cure. Recently, we identified the immunomodulatory enzyme indoleamine-2,3-dioxygenase 2 (IDO2) as an essential mediator of autoreactive B and T cell responses driving RA.… read more here.
Keywords: antibody; therapeutic antibody; dioxygenase ido2; indoleamine dioxygenase ... See more keywords
High-Throughput Therapeutic Antibody Interference-Free High-Resolution Mass Spectrometry Assay for Monitoring M-Proteins in Multiple Myeloma.
Sign Up to like & getrecommendations! Published in 2020 at "Analytical chemistry"
DOI: 10.1021/acs.analchem.0c03357
Abstract: Measurement of monoclonal antibodies (M-proteins) plays an important role in the diagnosis and treatment monitoring of multiple myeloma. Currently available M-protein assays have several limitations, particularly because of their lack of sensitivity and propensity to… read more here.
Keywords: mass spectrometry; throughput; interference; mass ... See more keywords
A broadly protective therapeutic antibody against influenza B virus with two mechanisms of action
Sign Up to like & getrecommendations! Published in 2017 at "Nature Communications"
DOI: 10.1038/ncomms14234
Abstract: Influenza B virus (IBV) causes annual influenza epidemics around the world. Here we use an in vivo plasmablast enrichment technique to isolate a human monoclonal antibody, 46B8 that neutralizes all IBVs tested in vitro and… read more here.
Keywords: broadly protective; antibody; protective therapeutic; therapeutic antibody ... See more keywords
Corrigendum: A broadly protective therapeutic antibody against influenza B virus with two mechanisms of action
Sign Up to like & getrecommendations! Published in 2017 at "Nature Communications"
DOI: 10.1038/ncomms15779
Abstract: This corrects the article DOI: 10.1038/ncomms14234. read more here.
Keywords: antibody influenza; influenza virus; protective therapeutic; therapeutic antibody ... See more keywords
Therapeutic antibody activation of the glucocorticoid-induced TNF receptor by a clustering mechanism
Sign Up to like & getrecommendations! Published in 2022 at "Science Advances"
DOI: 10.1126/sciadv.abm4552
Abstract: GITR is a TNF receptor, and its activation promotes immune responses and drives antitumor activity. The receptor is activated by the GITR ligand (GITRL), which is believed to cluster receptors into a high-order array. Immunotherapeutic… read more here.
Keywords: activation; therapeutic antibody; antibody; tnf receptor ... See more keywords
Combination therapy of therapeutic antibody and vaccine or entecavir in HBV carrier mice
Sign Up to like & getrecommendations! Published in 2023 at "Frontiers in Microbiology"
DOI: 10.3389/fmicb.2023.1173061
Abstract: Chronic infection with the hepatitis B virus (HBV) is a leading causes of liver cirrhosis and hepatocellular carcinoma. However, managing HBV treatments is challenging due to the lack of effective monotherapy. Here, we present two… read more here.
Keywords: therapy therapeutic; therapeutic antibody; hbv; combination ... See more keywords
Development of an Antibody Delivery Method for Cancer Treatment by Combining Ultrasound with Therapeutic Antibody-Modified Nanobubbles Using Fc-Binding Polypeptide
Sign Up to like & getrecommendations! Published in 2022 at "Pharmaceutics"
DOI: 10.3390/pharmaceutics15010130
Abstract: A key challenge in treating solid tumors is that the tumor microenvironment often inhibits the penetration of therapeutic antibodies into the tumor, leading to reduced therapeutic efficiency. It has been reported that the combination of… read more here.
Keywords: therapeutic antibody; antibody delivery; antibody modified; tus ... See more keywords