LAUSR

About LAUSR
Donate
Contact Us

Follow us:

You are not signed in:

Sign Up!


   Articles with "therapeutic antisense" as a keyword



Photo from archive.org

In Vivo Administration of Therapeutic Antisense Oligonucleotides.

Sign Up to like & get
recommendations! Published in 2021 at "Methods in molecular biology"

DOI: 10.1007/978-1-0716-1158-6_17

Abstract: With the rapid revolution in RNA/DNA sequencing technologies, it is evident that mammalian genomes express tens of thousands of long noncoding RNAs (lncRNAs). Since a large majority of lncRNAs have been functionally implicated in cancer… read more here.

Keywords: administration; vivo administration; therapeutic antisense; chemistry ... See more keywords
Photo by sxy_selia from unsplash

Dendrimer-Enabled Therapeutic Antisense Delivery Systems as Innovation in Medicine.

Sign Up to like & get
recommendations! Published in 2019 at "Bioconjugate chemistry"

DOI: 10.1021/acs.bioconjchem.9b00385

Abstract: Antisense oligonucleotide (AON)-based therapies concern the treatment for genetic disorders or infections such as a range of neurodegenerative and neuromuscular diseases and have shown benefits in animal models and patients. Nevertheless, successes in the clinic… read more here.

Keywords: medicine; antisense delivery; therapeutic antisense; dendrimer enabled ... See more keywords
Photo by nci from unsplash

Therapeutic Antisense Oligonucleotides Are Coming of Age.

Sign Up to like & get
recommendations! Published in 2019 at "Annual review of medicine"

DOI: 10.1146/annurev-med-041217-010829

Abstract: The first published description of therapeutic applications of antisense oligonucleotide (ASO) technology occurred in the late 1970s and was followed by the founding of commercial companies focused on developing antisense therapeutics in the late 1980s.… read more here.

Keywords: therapeutic antisense; oligonucleotides coming; chemistry; technology ... See more keywords
Photo by rgaleriacom from unsplash

Factors Influencing ADME properties of therapeutic antisense oligonucleotides: physicochemical characteristics and beyond.

Sign Up to like & get
recommendations! Published in 2023 at "Current drug metabolism"

DOI: 10.2174/1389200224666230418092626

Abstract: Therapeutic antisense oligonucleotides (ASOs) represent a diverse array of chemically modified singlestranded deoxyribonucleotides that work complementarily to affect their mRNA targets. They vastly differ from conventional small molecules. These newly developed therapeutic ASOs possess unique… read more here.

Keywords: factors influencing; adme; antisense oligonucleotides; adme properties ... See more keywords