Added therapeutic benefit and drug licensing
Sign Up to like & getrecommendations! Published in 2019 at "Nature Reviews Drug Discovery"
DOI: 10.1038/d41573-019-00068-x
Abstract: One aspect of the ongoing debate about drug pricing is the added therapeutic benefit of new drugs compared with existing — and potentially cheaper — therapies. Here, we discuss the merits and pitfalls of proposals… read more here.
Keywords: drug licensing; added therapeutic; therapeutic benefit; benefit drug ... See more keywords
Gene replacement therapy after neuropathy onset provides therapeutic benefit in a model of CMT1X.
Sign Up to like & getrecommendations! Published in 2019 at "Human molecular genetics"
DOI: 10.1093/hmg/ddz199
Abstract: X-linked Charcot-Marie-Tooth disease (CMT1X), one of the commonest forms of inherited demyelinating neuropathy, results from GJB1 gene mutations causing loss of function of the gap junction protein connexin32 (Cx32). The aim of this study was… read more here.
Keywords: replacement therapy; gene replacement; model; gene ... See more keywords
Abstract 5088: Tumor penetrating RNA delivery for therapeutic benefit of pancreatic cancer
Sign Up to like & getrecommendations! Published in 2017 at "Cancer Research"
DOI: 10.1158/1538-7445.am2017-5088
Abstract: Pancreatic cancer remains a deadly disease with a median survival of less than one year, in part because we lack effective therapeutic strategies. Mutations of the oncogene KRAS and the tumor suppressor genes TP53, INK4A,… read more here.
Keywords: delivery; pancreatic cancer; tumor penetrating; therapeutic benefit ... See more keywords
Potential therapeutic benefit of ursodeoxycholic acid in the management of non hepato-biliary upper gastrointestinal disorders.
Sign Up to like & getrecommendations! Published in 2023 at "Saudi medical journal"
DOI: 10.15537/smj.2023.44.5.20220886
Abstract: OBJECTIVES To examine the potential therapeutic effects of ursodeoxycholic acid (UDCA) on diseases of the esophagus, stomach, and duodenum. METHODS A search was conducted using EBSCO, Medline, PubMed, Google Scholar and Web of Science as… read more here.
Keywords: gastrointestinal disorders; ursodeoxycholic acid; therapeutic benefit; upper gastrointestinal ... See more keywords
The Therapeutic Benefit of Bacterial Membrane Vesicles
Sign Up to like & getrecommendations! Published in 2017 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms18061287
Abstract: The therapeutic potential of extracellular vesicles from eukaryotes has gained strong interest in recent years. However, research into the therapeutic application of their bacterial counterparts, known as bacterial membrane vesicles, is only just beginning to… read more here.
Keywords: membrane vesicles; bacterial membrane; therapeutic benefit; benefit bacterial ... See more keywords