Oral administration of a whole glucan particle (WGP)-based therapeutic cancer vaccine targeting macrophages inhibits tumor growth
Sign Up to like & getrecommendations! Published in 2022 at "Cancer Immunology, Immunotherapy"
DOI: 10.1007/s00262-021-03136-7
Abstract: Although therapeutic cancer vaccines have been gaining substantial ground, the development of cancer vaccines is impeded because of the undegradability of delivery systems, ineffective delivery of tumor antigens and weak immunogenicity of adjuvants. Here, we… read more here.
Keywords: cancer; whole glucan; tumor; glucan particle ... See more keywords
Turbocharging vaccines: emerging adjuvants for dendritic cell based therapeutic cancer vaccines.
Sign Up to like & getrecommendations! Published in 2017 at "Current opinion in immunology"
DOI: 10.1016/j.coi.2017.06.003
Abstract: Development of therapeutic cancer vaccines has been hindered by the many pro-tumorigenic mechanisms at play in cancer patients that serve to suppress both antigen presenting cells and T cells. In face of these obstacles, cancer… read more here.
Keywords: vaccines emerging; turbocharging vaccines; emerging adjuvants; cancer ... See more keywords
Correlates of immune and clinical activity of novel cancer vaccines.
Sign Up to like & getrecommendations! Published in 2018 at "Seminars in Immunology"
DOI: 10.1016/j.smim.2018.04.001
Abstract: Cancer vaccines are solely meant to amplify the pool of type 1 cytokine oriented CD4+ and CD8+ T cells that recognize tumor antigen and ultimately foster control and destruction of a growing tumor. They are… read more here.
Keywords: cancer vaccines; clinical activity; cancer; therapeutic cancer ... See more keywords
Avelumab in Men With Metastatic Castration-Resistant Prostate Cancer, Enriched for Patients Treated Previously With a Therapeutic Cancer Vaccine
Sign Up to like & getrecommendations! Published in 2023 at "Journal of Immunotherapy (Hagerstown, Md. : 1997)"
DOI: 10.1097/cji.0000000000000459
Abstract: Therapeutic cancer vaccines including sipuleucel-T, a prostatic acid phosphatase (PAP) targeted vaccine that improves survival in metastatic castration-resistant prostate cancer (mCRPC), can produce immune responses that translate to clinical benefit. The effects of sequential checkpoint… read more here.
Keywords: cancer vaccine; therapeutic cancer; prostate cancer; cancer ... See more keywords
759 Development of an implantable artificial lymph node as a therapeutic cancer vaccine
Sign Up to like & getrecommendations! Published in 2020 at "Journal for ImmunoTherapy of Cancer"
DOI: 10.1136/jitc-2020-sitc2020.0759
Abstract: Background Personalized therapeutic cancer vaccines aim to target and reprogram the host immune system to achieve cancer eradication in situ. Cancer vaccines deliver two main components: immunostimulants (iS) and tumor antigens to reduce tumor burden… read more here.
Keywords: 759 development; cancer vaccine; cancer; vaccine ... See more keywords
An IL-2 Protein Therapeutic for Cancer that Gains Function on the Spot.
Sign Up to like & getrecommendations! Published in 2022 at "Cancer immunology research"
DOI: 10.1158/2326-6066.cir-22-0186
Abstract: Recombinant human IL-2 (rhIL-2) is now rarely used to treat patients with cancer because it too often causes severe toxicities. In this issue, Nirschl and colleagues report the development and preclinical characterization of an engineered… read more here.
Keywords: cancer gains; protein therapeutic; function spot; therapeutic cancer ... See more keywords
Therapeutic Cancer Vaccination With a Peptide Derived From the Calreticulin Exon 9 Mutations Induces Strong Cellular Immune Responses in Patients With CALR-Mutant Chronic Myeloproliferative Neoplasms
Sign Up to like & getrecommendations! Published in 2021 at "Frontiers in Oncology"
DOI: 10.3389/fonc.2021.637420
Abstract: Background The calreticulin (CALR) exon 9 mutations that are identified in 20% of patients with Philadelphia chromosome negative chronic myeloproliferative neoplasms (MPN) generate immunogenic antigens. Thus, therapeutic cancer vaccination against mutant CALR could be a… read more here.
Keywords: response; exon mutations; therapeutic cancer; vaccination ... See more keywords
Therapeutic Cancer Vaccines—Antigen Discovery and Adjuvant Delivery Platforms
Sign Up to like & getrecommendations! Published in 2022 at "Pharmaceutics"
DOI: 10.3390/pharmaceutics14071448
Abstract: For decades, vaccines have played a significant role in protecting public and personal health against infectious diseases and proved their great potential in battling cancers as well. This review focused on the current progress of… read more here.
Keywords: vaccines antigen; delivery platforms; therapeutic cancer; cancer vaccines ... See more keywords
Virus-like Particles as Preventive and Therapeutic Cancer Vaccines
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DOI: 10.3390/vaccines10020227
Abstract: Virus-like particles (VLPs) are self-assembled viral protein complexes that mimic the native virus structure without being infectious. VLPs, similarly to wild type viruses, are able to efficiently target and activate dendritic cells (DCs) triggering the… read more here.
Keywords: preventive therapeutic; like particles; particles preventive; vaccines virus ... See more keywords
Therapeutic Cancer Vaccines and Their Future Implications
Sign Up to like & getrecommendations! Published in 2023 at "Vaccines"
DOI: 10.3390/vaccines11030660
Abstract: The continuous progress in vaccine development witnessed in the last decades, culminated with the development of vaccines against cancers, is set to change how various cancers are treated [...]. read more here.
Keywords: therapeutic cancer; vaccines future; future implications; cancer vaccines ... See more keywords